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A comparison of extension and severity of perfusion, glucose metabolism and wall motion abnormalities in recent myocardial infarction on patients with and without revascularization

Abstract

Aim: To compare the extension and severity in perfusion, glucose metabolism and contractility abnormalities in recent myocardial infarction, assessed by different imaging modalities, and to evaluate these functional parameters in patients with and without revascularization (REV). Materials and methods: We assessed 49 patients with a first MI (58 {+-}12 years; 82 % males) using 1) [Tl201] rest SPECT, 2) [Tl201] redistribution (red) SPECT, 3) [F18]FDG SPECT and 4) 2D echocardiograms at a mean of 9.2 days, range: 1-24; 29 (59%) patients had been REV by means of PTCA or CABG and 20 (41%) underwent only medical therapy. All had angiogram. Images were analyzed blindly, employing the same polar map which included 17 segments in the four sets of studies. Both, the number of segments involved and their severity (normal, mild, moderate or markedly abnormal) using a semiquantitative score from 1 to 4 were tabulated. Results: In the total group (n=833 segments), the abnormal segments in echo were 302 (36%), in Tl rest 231 (28%), in Tl red 223 (26%) and in FDG 202 (24%), (p<0.001 echo vs all other). Regarding severity score, the median (s.d.) values were: 2.6 (0.5); 2.9 (0.9); 2.8 (1.2) and 2.9 (1.2), respectively (p<0.01 echo vs  More>>
Authors:
Gonzalez, P; [1]  Department of Nuclear Medicine of Santa Maria Clinic (Chile)]; Massardo, T; Coll, C; Redondo, F; Jofre, J; Sierralta, P; [1]  Humeres, P; [2]  Yovanovich, J; [3]  Chamorro, H [4] 
  1. Department of Nuclear Medicine of the University of Chile Clinical Hospital (Chile)
  2. Department of Nuclear Medicine of Santa Maria Clinic (Chile)
  3. Cardiovascular Center of the University of Chile Clinical Hospital (Chile)
  4. Cardiovascular Center of Santa Maria Clinic, Santiago (Chile)
Publication Date:
Sep 01, 2002
Product Type:
Journal Article
Resource Relation:
Journal Name: World Journal of Nuclear Medicine; Journal Volume: 1; Journal Issue: suppl.2; Conference: 8. Congress of the World Federation of Nuclear Medicine and Biology, Santiago (Chile), 29 Sep - 2 Oct 2002; Other Information: 1 tab; PBD: Sep 2002
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CARDIOVASCULAR SYSTEM; DIAGNOSIS; GLUCOSE; METABOLISM; MYOCARDIAL INFARCTION; MYOCARDIUM; PERFUSED ORGANS; RADIONUCLIDE KINETICS; RADIOPHARMACEUTICALS; SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY; THALLIUM 201
OSTI ID:
20332416
Country of Origin:
IAEA
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 1450-1147; TRN: XA03W0027020548
Submitting Site:
INIS
Size:
page(s) 9
Announcement Date:
Apr 03, 2003

Citation Formats

Gonzalez, P, Department of Nuclear Medicine of Santa Maria Clinic (Chile)], Massardo, T, Coll, C, Redondo, F, Jofre, J, Sierralta, P, Humeres, P, Yovanovich, J, and Chamorro, H. A comparison of extension and severity of perfusion, glucose metabolism and wall motion abnormalities in recent myocardial infarction on patients with and without revascularization. IAEA: N. p., 2002. Web.
Gonzalez, P, Department of Nuclear Medicine of Santa Maria Clinic (Chile)], Massardo, T, Coll, C, Redondo, F, Jofre, J, Sierralta, P, Humeres, P, Yovanovich, J, &amp; Chamorro, H. A comparison of extension and severity of perfusion, glucose metabolism and wall motion abnormalities in recent myocardial infarction on patients with and without revascularization. IAEA.
Gonzalez, P, Department of Nuclear Medicine of Santa Maria Clinic (Chile)], Massardo, T, Coll, C, Redondo, F, Jofre, J, Sierralta, P, Humeres, P, Yovanovich, J, and Chamorro, H. 2002. "A comparison of extension and severity of perfusion, glucose metabolism and wall motion abnormalities in recent myocardial infarction on patients with and without revascularization." IAEA.
@misc{etde_20332416,
title = {A comparison of extension and severity of perfusion, glucose metabolism and wall motion abnormalities in recent myocardial infarction on patients with and without revascularization}
author = {Gonzalez, P, Department of Nuclear Medicine of Santa Maria Clinic (Chile)], Massardo, T, Coll, C, Redondo, F, Jofre, J, Sierralta, P, Humeres, P, Yovanovich, J, and Chamorro, H}
abstractNote = {Aim: To compare the extension and severity in perfusion, glucose metabolism and contractility abnormalities in recent myocardial infarction, assessed by different imaging modalities, and to evaluate these functional parameters in patients with and without revascularization (REV). Materials and methods: We assessed 49 patients with a first MI (58 {+-}12 years; 82 % males) using 1) [Tl201] rest SPECT, 2) [Tl201] redistribution (red) SPECT, 3) [F18]FDG SPECT and 4) 2D echocardiograms at a mean of 9.2 days, range: 1-24; 29 (59%) patients had been REV by means of PTCA or CABG and 20 (41%) underwent only medical therapy. All had angiogram. Images were analyzed blindly, employing the same polar map which included 17 segments in the four sets of studies. Both, the number of segments involved and their severity (normal, mild, moderate or markedly abnormal) using a semiquantitative score from 1 to 4 were tabulated. Results: In the total group (n=833 segments), the abnormal segments in echo were 302 (36%), in Tl rest 231 (28%), in Tl red 223 (26%) and in FDG 202 (24%), (p<0.001 echo vs all other). Regarding severity score, the median (s.d.) values were: 2.6 (0.5); 2.9 (0.9); 2.8 (1.2) and 2.9 (1.2), respectively (p<0.01 echo vs all other). In REV patients (n=493), the lesion size was 154 segments (31%), 116 (23%), 112 (23%) and 100 (20%), respectively. In those without REV (n=340) the number of abnormal segments were 148 (44%), 115 (34%), 111 (33%) and 102 (30%) respectively (p<0.004, REV vs no REV). McNemar, Student t tests were used in the comparisons. Conclusion: In recent MI, echo abnormalities were bigger in size (up to 13%) than the perfusion and metabolic defects, but less severe (down to 10%) compared to radionuclide procedures, possibly due to stunning. Non REV patients presented with greater extension (up to 11%) and more severity (up to 22%) than REV ones in any of the imaging modalities, explained by therapy effect. Both, echo and radionuclide techniques appear adequate to demonstrate revascularization benefit.}
journal = []
issue = {suppl.2}
volume = {1}
journal type = {AC}
place = {IAEA}
year = {2002}
month = {Sep}
}