Abstract
Hydrogels, i.e. materials consisting of a permanent, three-dimensional network of hydrophilic polymers and water filling the space between the polymer chains, have a number of biomedical applications, such as wound care products, dental and ophthalmic materials, drug delivery systems, elements of implants, constituents of hybrid-type organs, as well as stimuli-sensitive systems. Among various methods applied for the production of hydrogels, the radiation technique has many advantages, as a simple, efficient, clean and environment-friendly process. It usually allows to combine the synthesis and sterilization in a single technological step, thus reducing costs and production time. Efficient application and further development of this method requires broadening of the basic knowledge on the underlying radiation chemistry of polymer systems. Some selected aspects of radiation chemistry of polymers in aqueous solution are presented in this work. The experimental techniques used for studying the radiation-induced processes in polymer solutions are described with special emphasizing of determination of radiation yield of crosslinking by various methods. Also, pulse radiolysis method with different detection methods is briefly described. Selected results of our studies concerning the early stages of polymerization of water-soluble monomers are described together with the studies of mechanisms of radiation-induced crosslinking of polymers in aqueous solution.
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Rosiak, J M;
Janik, I;
Kadlubowski, S;
Kozicki, M;
Kujawa, P;
Stasica, P;
Ulanski, P
[1]
- Institute of Applied Radiation Chemistry, Technical University of Lodz (Poland)
Citation Formats
Rosiak, J M, Janik, I, Kadlubowski, S, Kozicki, M, Kujawa, P, Stasica, P, and Ulanski, P.
Radiation formation of hydrogels for biomedical application.
IAEA: N. p.,
2002.
Web.
Rosiak, J M, Janik, I, Kadlubowski, S, Kozicki, M, Kujawa, P, Stasica, P, & Ulanski, P.
Radiation formation of hydrogels for biomedical application.
IAEA.
Rosiak, J M, Janik, I, Kadlubowski, S, Kozicki, M, Kujawa, P, Stasica, P, and Ulanski, P.
2002.
"Radiation formation of hydrogels for biomedical application."
IAEA.
@misc{etde_20330111,
title = {Radiation formation of hydrogels for biomedical application}
author = {Rosiak, J M, Janik, I, Kadlubowski, S, Kozicki, M, Kujawa, P, Stasica, P, and Ulanski, P}
abstractNote = {Hydrogels, i.e. materials consisting of a permanent, three-dimensional network of hydrophilic polymers and water filling the space between the polymer chains, have a number of biomedical applications, such as wound care products, dental and ophthalmic materials, drug delivery systems, elements of implants, constituents of hybrid-type organs, as well as stimuli-sensitive systems. Among various methods applied for the production of hydrogels, the radiation technique has many advantages, as a simple, efficient, clean and environment-friendly process. It usually allows to combine the synthesis and sterilization in a single technological step, thus reducing costs and production time. Efficient application and further development of this method requires broadening of the basic knowledge on the underlying radiation chemistry of polymer systems. Some selected aspects of radiation chemistry of polymers in aqueous solution are presented in this work. The experimental techniques used for studying the radiation-induced processes in polymer solutions are described with special emphasizing of determination of radiation yield of crosslinking by various methods. Also, pulse radiolysis method with different detection methods is briefly described. Selected results of our studies concerning the early stages of polymerization of water-soluble monomers are described together with the studies of mechanisms of radiation-induced crosslinking of polymers in aqueous solution. Separate section of the presentation is devoted to the radiation-induced crosslinking and degradation of polyelectrolytes (i.e. poly (poly (acrylic acid)), poly (poly (methacrylic acid))) and biologically important polysaccharide, chitosan. Additionally, special attention is paid to the differences between intra- and intermolecular crosslinking. The irradiation method of changing the proportion between these two processes at the expense on intramolecular crosslinking is described. This leads to the synthesis of internally crosslinked polymeric single coils, i.e. nanogels. The selected properties of such materials are described. Some expectations as to the further research directions in the field of radiation-synthesized hydrogels and examples of their biomedical applications also presented. They include e.g. wound dressings, drug delivery systems, stimuli-responsive systems, implants and hydrogel-based hybrid-type organs. (author)}
place = {IAEA}
year = {2002}
month = {Dec}
}
title = {Radiation formation of hydrogels for biomedical application}
author = {Rosiak, J M, Janik, I, Kadlubowski, S, Kozicki, M, Kujawa, P, Stasica, P, and Ulanski, P}
abstractNote = {Hydrogels, i.e. materials consisting of a permanent, three-dimensional network of hydrophilic polymers and water filling the space between the polymer chains, have a number of biomedical applications, such as wound care products, dental and ophthalmic materials, drug delivery systems, elements of implants, constituents of hybrid-type organs, as well as stimuli-sensitive systems. Among various methods applied for the production of hydrogels, the radiation technique has many advantages, as a simple, efficient, clean and environment-friendly process. It usually allows to combine the synthesis and sterilization in a single technological step, thus reducing costs and production time. Efficient application and further development of this method requires broadening of the basic knowledge on the underlying radiation chemistry of polymer systems. Some selected aspects of radiation chemistry of polymers in aqueous solution are presented in this work. The experimental techniques used for studying the radiation-induced processes in polymer solutions are described with special emphasizing of determination of radiation yield of crosslinking by various methods. Also, pulse radiolysis method with different detection methods is briefly described. Selected results of our studies concerning the early stages of polymerization of water-soluble monomers are described together with the studies of mechanisms of radiation-induced crosslinking of polymers in aqueous solution. Separate section of the presentation is devoted to the radiation-induced crosslinking and degradation of polyelectrolytes (i.e. poly (poly (acrylic acid)), poly (poly (methacrylic acid))) and biologically important polysaccharide, chitosan. Additionally, special attention is paid to the differences between intra- and intermolecular crosslinking. The irradiation method of changing the proportion between these two processes at the expense on intramolecular crosslinking is described. This leads to the synthesis of internally crosslinked polymeric single coils, i.e. nanogels. The selected properties of such materials are described. Some expectations as to the further research directions in the field of radiation-synthesized hydrogels and examples of their biomedical applications also presented. They include e.g. wound dressings, drug delivery systems, stimuli-responsive systems, implants and hydrogel-based hybrid-type organs. (author)}
place = {IAEA}
year = {2002}
month = {Dec}
}