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HPRT gene locus mutation in peripheral blood lymphocytes induced by internal exposure to radionuclides

Abstract

HPRT gene locus mutation in peripheral blood lymphocytes induced by internal exposure to radionuclides was performed and the relationships between mutation frequency and dose were studied. Rats were injected intravenously with radionuclides, the blood was sampled at different time after injection; HPRT gene locus mutation frequency (GMF) were examined by methods of multi-nucleus cell and Brdurd assay, working out the Dose-response function. GMF rose with the increase of dose and dose-rates and were clearly interrelated. The HPRT gene locus mutation is very sensitive to radiation and may be used as a biological dosimeter.
Authors:
Jingyong, Zhao; Yongzhong, Xu; Tao, Zhao; Fengmei, Cui; Liuyi, Wang; Qinhua, Lao [1] 
  1. Suzhou Univ., Suzhou (China). Radiation Medicine Department
Publication Date:
Jul 01, 2001
Product Type:
Technical Report
Report Number:
CNIC-01583; SZU-0002
Resource Relation:
Other Information: Data in PDF format: Acrobat Reader for r for Windows 9x; CNIC/CD/2001-3; PBD: 2001; Related Information: China Nuclear Science and Technology Report
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; BIOLOGICAL DOSEMETERS; BIOLOGICAL RADIATION EFFECTS; BLOOD; DOSE RATES; DOSE-RESPONSE RELATIONSHIPS; GENE MUTATIONS; INTERNAL IRRADIATION; INTRAVENOUS INJECTION; LYMPHOCYTES; MUTATION FREQUENCY; RADIATION DOSES; RADIOISOTOPES; RATS
OSTI ID:
20315874
Research Organizations:
China Nuclear Information Centre, Beijing (China)
Country of Origin:
China
Language:
Chinese
Other Identifying Numbers:
Other: ISBN 7-89998-073-9; TRN: CN0300021007006
Availability:
Available from INIS in electronic form
Submitting Site:
INIS
Size:
13 pages
Announcement Date:

Citation Formats

Jingyong, Zhao, Yongzhong, Xu, Tao, Zhao, Fengmei, Cui, Liuyi, Wang, and Qinhua, Lao. HPRT gene locus mutation in peripheral blood lymphocytes induced by internal exposure to radionuclides. China: N. p., 2001. Web.
Jingyong, Zhao, Yongzhong, Xu, Tao, Zhao, Fengmei, Cui, Liuyi, Wang, & Qinhua, Lao. HPRT gene locus mutation in peripheral blood lymphocytes induced by internal exposure to radionuclides. China.
Jingyong, Zhao, Yongzhong, Xu, Tao, Zhao, Fengmei, Cui, Liuyi, Wang, and Qinhua, Lao. 2001. "HPRT gene locus mutation in peripheral blood lymphocytes induced by internal exposure to radionuclides." China.
@misc{etde_20315874,
title = {HPRT gene locus mutation in peripheral blood lymphocytes induced by internal exposure to radionuclides}
author = {Jingyong, Zhao, Yongzhong, Xu, Tao, Zhao, Fengmei, Cui, Liuyi, Wang, and Qinhua, Lao}
abstractNote = {HPRT gene locus mutation in peripheral blood lymphocytes induced by internal exposure to radionuclides was performed and the relationships between mutation frequency and dose were studied. Rats were injected intravenously with radionuclides, the blood was sampled at different time after injection; HPRT gene locus mutation frequency (GMF) were examined by methods of multi-nucleus cell and Brdurd assay, working out the Dose-response function. GMF rose with the increase of dose and dose-rates and were clearly interrelated. The HPRT gene locus mutation is very sensitive to radiation and may be used as a biological dosimeter.}
place = {China}
year = {2001}
month = {Jul}
}