Abstract
Radioiodine labeled benzamides are being studied as radiopharmaceuticals for the detection of melanomas and metastases. With this purpose the synthesis and labeling of N-(2-diethylaminoethyl)-3-[{sup 131}I]-4-methoxybenzamide (IMBA) has been carried out. Tissue distribution of the labeled compound has been studied in C 57 mice, showing a fast renal excretion. The labeled benzamide was also injected in mice with previously induced subcutaneous melanomas and lung metastases using B 16-F0 murine melanoma cells. The tumors show a good uptake of the labeled benzamide. The melanoma/other tissues uptake ratio is suitable for scintigraphic detection. Clinical studies in patients are under way. (author)
Pozzi, Oscar R;
Edreira, Martin M;
Castiglia, Silvia G;
[1]
Zarlenga, Ana C;
Arashiro, Jorge G;
Parma, P;
[2]
Soroa, Victoria E
[3]
- Comision Nacional de Energia Atomica, Ezeiza (Argentina). Dept. de Radioquimica
- Instituto de Oncologia Angel H. Roffo, Buenos Aires (Argentina)
- Hospital Clinicas Jose de San Martin, Buenos Aires (Argentina)
Citation Formats
Pozzi, Oscar R, Edreira, Martin M, Castiglia, Silvia G, Zarlenga, Ana C, Arashiro, Jorge G, Parma, P, and Soroa, Victoria E.
131/123 iodine labeled benzamides for the detection of melanomas and metastases. Synthesis, labeling, animal experiences and preliminary clinical studies; Benzamidas marcadas con 131/123 iodo para deteccion de melanomas y metastasis. Sintesis, marcacion, estudio en animales y primeros estudios clinicos.
Argentina: N. p.,
1999.
Web.
Pozzi, Oscar R, Edreira, Martin M, Castiglia, Silvia G, Zarlenga, Ana C, Arashiro, Jorge G, Parma, P, & Soroa, Victoria E.
131/123 iodine labeled benzamides for the detection of melanomas and metastases. Synthesis, labeling, animal experiences and preliminary clinical studies; Benzamidas marcadas con 131/123 iodo para deteccion de melanomas y metastasis. Sintesis, marcacion, estudio en animales y primeros estudios clinicos.
Argentina.
Pozzi, Oscar R, Edreira, Martin M, Castiglia, Silvia G, Zarlenga, Ana C, Arashiro, Jorge G, Parma, P, and Soroa, Victoria E.
1999.
"131/123 iodine labeled benzamides for the detection of melanomas and metastases. Synthesis, labeling, animal experiences and preliminary clinical studies; Benzamidas marcadas con 131/123 iodo para deteccion de melanomas y metastasis. Sintesis, marcacion, estudio en animales y primeros estudios clinicos."
Argentina.
@misc{etde_20302864,
title = {131/123 iodine labeled benzamides for the detection of melanomas and metastases. Synthesis, labeling, animal experiences and preliminary clinical studies; Benzamidas marcadas con 131/123 iodo para deteccion de melanomas y metastasis. Sintesis, marcacion, estudio en animales y primeros estudios clinicos}
author = {Pozzi, Oscar R, Edreira, Martin M, Castiglia, Silvia G, Zarlenga, Ana C, Arashiro, Jorge G, Parma, P, and Soroa, Victoria E}
abstractNote = {Radioiodine labeled benzamides are being studied as radiopharmaceuticals for the detection of melanomas and metastases. With this purpose the synthesis and labeling of N-(2-diethylaminoethyl)-3-[{sup 131}I]-4-methoxybenzamide (IMBA) has been carried out. Tissue distribution of the labeled compound has been studied in C 57 mice, showing a fast renal excretion. The labeled benzamide was also injected in mice with previously induced subcutaneous melanomas and lung metastases using B 16-F0 murine melanoma cells. The tumors show a good uptake of the labeled benzamide. The melanoma/other tissues uptake ratio is suitable for scintigraphic detection. Clinical studies in patients are under way. (author)}
place = {Argentina}
year = {1999}
month = {Jul}
}
title = {131/123 iodine labeled benzamides for the detection of melanomas and metastases. Synthesis, labeling, animal experiences and preliminary clinical studies; Benzamidas marcadas con 131/123 iodo para deteccion de melanomas y metastasis. Sintesis, marcacion, estudio en animales y primeros estudios clinicos}
author = {Pozzi, Oscar R, Edreira, Martin M, Castiglia, Silvia G, Zarlenga, Ana C, Arashiro, Jorge G, Parma, P, and Soroa, Victoria E}
abstractNote = {Radioiodine labeled benzamides are being studied as radiopharmaceuticals for the detection of melanomas and metastases. With this purpose the synthesis and labeling of N-(2-diethylaminoethyl)-3-[{sup 131}I]-4-methoxybenzamide (IMBA) has been carried out. Tissue distribution of the labeled compound has been studied in C 57 mice, showing a fast renal excretion. The labeled benzamide was also injected in mice with previously induced subcutaneous melanomas and lung metastases using B 16-F0 murine melanoma cells. The tumors show a good uptake of the labeled benzamide. The melanoma/other tissues uptake ratio is suitable for scintigraphic detection. Clinical studies in patients are under way. (author)}
place = {Argentina}
year = {1999}
month = {Jul}
}