You need JavaScript to view this

131/123 iodine labeled benzamides for the detection of melanomas and metastases. Synthesis, labeling, animal experiences and preliminary clinical studies; Benzamidas marcadas con 131/123 iodo para deteccion de melanomas y metastasis. Sintesis, marcacion, estudio en animales y primeros estudios clinicos

Abstract

Radioiodine labeled benzamides are being studied as radiopharmaceuticals for the detection of melanomas and metastases. With this purpose the synthesis and labeling of N-(2-diethylaminoethyl)-3-[{sup 131}I]-4-methoxybenzamide (IMBA) has been carried out. Tissue distribution of the labeled compound has been studied in C 57 mice, showing a fast renal excretion. The labeled benzamide was also injected in mice with previously induced subcutaneous melanomas and lung metastases using B 16-F0 murine melanoma cells. The tumors show a good uptake of the labeled benzamide. The melanoma/other tissues uptake ratio is suitable for scintigraphic detection. Clinical studies in patients are under way. (author)
Authors:
Pozzi, Oscar R; Edreira, Martin M; Castiglia, Silvia G; [1]  Zarlenga, Ana C; Arashiro, Jorge G; Parma, P; [2]  Soroa, Victoria E [3] 
  1. Comision Nacional de Energia Atomica, Ezeiza (Argentina). Dept. de Radioquimica
  2. Instituto de Oncologia Angel H. Roffo, Buenos Aires (Argentina)
  3. Hospital Clinicas Jose de San Martin, Buenos Aires (Argentina)
Publication Date:
Jul 01, 1999
Product Type:
Conference
Report Number:
INIS-AR-C-227
Resource Relation:
Conference: AATN '99: 26. Annual meeting of the Argentine Association of Nuclear Technology (AANT), AATN '99: 26. Reunion anual de la Asociacion Argentina de Tecnologia Nuclear (AATN), San Carlos de Bariloche (Argentina), 9-12 Nov 1999; Other Information: 9 refs; PBD: 1999
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; IODINE 123; IODINE 131; MELANOMAS; RADIOPHARMACEUTICALS; TISSUE DISTRIBUTION
OSTI ID:
20302864
Country of Origin:
Argentina
Language:
Spanish
Other Identifying Numbers:
TRN: AR02C0105064218
Availability:
Available from INIS in electronic form
Submitting Site:
INIS
Size:
4 pages
Announcement Date:
Dec 16, 2002

Citation Formats

Pozzi, Oscar R, Edreira, Martin M, Castiglia, Silvia G, Zarlenga, Ana C, Arashiro, Jorge G, Parma, P, and Soroa, Victoria E. 131/123 iodine labeled benzamides for the detection of melanomas and metastases. Synthesis, labeling, animal experiences and preliminary clinical studies; Benzamidas marcadas con 131/123 iodo para deteccion de melanomas y metastasis. Sintesis, marcacion, estudio en animales y primeros estudios clinicos. Argentina: N. p., 1999. Web.
Pozzi, Oscar R, Edreira, Martin M, Castiglia, Silvia G, Zarlenga, Ana C, Arashiro, Jorge G, Parma, P, & Soroa, Victoria E. 131/123 iodine labeled benzamides for the detection of melanomas and metastases. Synthesis, labeling, animal experiences and preliminary clinical studies; Benzamidas marcadas con 131/123 iodo para deteccion de melanomas y metastasis. Sintesis, marcacion, estudio en animales y primeros estudios clinicos. Argentina.
Pozzi, Oscar R, Edreira, Martin M, Castiglia, Silvia G, Zarlenga, Ana C, Arashiro, Jorge G, Parma, P, and Soroa, Victoria E. 1999. "131/123 iodine labeled benzamides for the detection of melanomas and metastases. Synthesis, labeling, animal experiences and preliminary clinical studies; Benzamidas marcadas con 131/123 iodo para deteccion de melanomas y metastasis. Sintesis, marcacion, estudio en animales y primeros estudios clinicos." Argentina.
@misc{etde_20302864,
title = {131/123 iodine labeled benzamides for the detection of melanomas and metastases. Synthesis, labeling, animal experiences and preliminary clinical studies; Benzamidas marcadas con 131/123 iodo para deteccion de melanomas y metastasis. Sintesis, marcacion, estudio en animales y primeros estudios clinicos}
author = {Pozzi, Oscar R, Edreira, Martin M, Castiglia, Silvia G, Zarlenga, Ana C, Arashiro, Jorge G, Parma, P, and Soroa, Victoria E}
abstractNote = {Radioiodine labeled benzamides are being studied as radiopharmaceuticals for the detection of melanomas and metastases. With this purpose the synthesis and labeling of N-(2-diethylaminoethyl)-3-[{sup 131}I]-4-methoxybenzamide (IMBA) has been carried out. Tissue distribution of the labeled compound has been studied in C 57 mice, showing a fast renal excretion. The labeled benzamide was also injected in mice with previously induced subcutaneous melanomas and lung metastases using B 16-F0 murine melanoma cells. The tumors show a good uptake of the labeled benzamide. The melanoma/other tissues uptake ratio is suitable for scintigraphic detection. Clinical studies in patients are under way. (author)}
place = {Argentina}
year = {1999}
month = {Jul}
}