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Biological effects of ionizing radiation; Efectos biologicos de la radiacion

Abstract

It has been emphasised the importance of DNA as the main target for ionizing radiation, that can induce damage by its direct action on this molecule or by an indirect effect mediated by free-radicals generated by water radiolysis. Biological effects of ionizing radiation are influenced not only by the dose but also by the dose-rate and the radiation quality. Radiation induced damage, mainly DNA single and double strand breaks, is detected by molecular sensors which in turn trigger signalling cascades leading to cell cycle arrest to allow DNA repair or programmed cell death (apoptosis). Those effects related with cell death, named deterministic, exhibits a dose-threshold below which they are not observed. Acute radiation syndrome and radiological burns are examples of this kind of effects. Other radiation induced effects, called stochastic, are the consequence of cell transformation and do not exhibit a dose-threshold. This is the case of cancer induction and hereditary effects. The aim of this presentation is briefly describe the main aspects of deterministic and stochastic effects from the point of view of radiobiology and radio pathology. (author)
Authors:
Gisone, Pablo; Perez, Maria R [1] 
  1. Autoridad Regulatoria Nuclear, Buenos Aires (Argentina)
Publication Date:
Jul 01, 2001
Product Type:
Conference
Report Number:
INIS-AR-C-193
Resource Relation:
Conference: Sessions of the Argentine Radioprotection Society on prenatal exposition on ionizing radiations, Jornadas de la Sociedad Argentina de Radioproteccion sobre exposicion prenatal a las radiaciones ionizantes, Buenos Aires (Argentina), 8-9 Nov 2001; Other Information: 8 figs; PBD: 2001; Related Information: In: Prenatal exposition on ionizing radiations, Exposicion prenatal a las radiaciones ionizantes, 99 pages.
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; APOPTOSIS; BIOLOGICAL RADIATION EFFECTS; CARCINOGENESIS; CHROMOSOMAL ABERRATIONS; DNA; EPIDEMIOLOGY; GENETIC EFFECTS; IONIZING RADIATIONS; RADIATION INDUCED MUTANTS; RADICALS; RADIOBIOLOGY; STOCHASTIC PROCESSES; THRESHOLD DOSE
OSTI ID:
20291001
Research Organizations:
Sociedad Argentina de Radioproteccion (SAR), Buenos Aires (Argentina)
Country of Origin:
Argentina
Language:
Spanish
Other Identifying Numbers:
TRN: AR02C0061052454
Availability:
Available from INIS in electronic form
Submitting Site:
INIS
Size:
page(s) 3-25
Announcement Date:

Citation Formats

Gisone, Pablo, and Perez, Maria R. Biological effects of ionizing radiation; Efectos biologicos de la radiacion. Argentina: N. p., 2001. Web.
Gisone, Pablo, & Perez, Maria R. Biological effects of ionizing radiation; Efectos biologicos de la radiacion. Argentina.
Gisone, Pablo, and Perez, Maria R. 2001. "Biological effects of ionizing radiation; Efectos biologicos de la radiacion." Argentina.
@misc{etde_20291001,
title = {Biological effects of ionizing radiation; Efectos biologicos de la radiacion}
author = {Gisone, Pablo, and Perez, Maria R}
abstractNote = {It has been emphasised the importance of DNA as the main target for ionizing radiation, that can induce damage by its direct action on this molecule or by an indirect effect mediated by free-radicals generated by water radiolysis. Biological effects of ionizing radiation are influenced not only by the dose but also by the dose-rate and the radiation quality. Radiation induced damage, mainly DNA single and double strand breaks, is detected by molecular sensors which in turn trigger signalling cascades leading to cell cycle arrest to allow DNA repair or programmed cell death (apoptosis). Those effects related with cell death, named deterministic, exhibits a dose-threshold below which they are not observed. Acute radiation syndrome and radiological burns are examples of this kind of effects. Other radiation induced effects, called stochastic, are the consequence of cell transformation and do not exhibit a dose-threshold. This is the case of cancer induction and hereditary effects. The aim of this presentation is briefly describe the main aspects of deterministic and stochastic effects from the point of view of radiobiology and radio pathology. (author)}
place = {Argentina}
year = {2001}
month = {Jul}
}