Abstract
A simple method of preparation of a new therapeutic colloid, samarium(III) phosphate-{sup 153}Sm (SMPC), is reported involving the reaction of carrier-added {sup 153}SmCl{sub 3} with phosphoric acid. Recovery of the colloid was accomplished by dialysis leading to purification and a radiochemical (RC) yield of more than 90%. The RC purity of purified colloid formulated in isotonic phosphate buffer was more than 99% as assessed by paper chromatography. The product retained its RC purity throughout the period of stability study of 7 days. Complete retention of radioactivity instilled in the rabbit knee joint was observed over the study period of 6 days, with radioactivity in the blood being indistinguishable from the natural background activity. Ninety-six percent of colloidal particles were in the size range of 0.3-2 {mu}m. The promising results demonstrated warrant further studies on SMPC for assessing the suitability for therapy.
Citation Formats
Prabhakar, G, Joshi, Sangeeta H, Ranganatha, D K, Umamaheswari, S, Ananthakrishnan, M, and Ramamoorthy, N.
Preparation and evaluation of samarium (III) phosphate [{sup 153}Sm] colloid (SMPC) for possible therapeutic use.
United Kingdom: N. p.,
2000.
Web.
doi:10.1016/S0969-8051(00)00097-4.
Prabhakar, G, Joshi, Sangeeta H, Ranganatha, D K, Umamaheswari, S, Ananthakrishnan, M, & Ramamoorthy, N.
Preparation and evaluation of samarium (III) phosphate [{sup 153}Sm] colloid (SMPC) for possible therapeutic use.
United Kingdom.
https://doi.org/10.1016/S0969-8051(00)00097-4
Prabhakar, G, Joshi, Sangeeta H, Ranganatha, D K, Umamaheswari, S, Ananthakrishnan, M, and Ramamoorthy, N.
2000.
"Preparation and evaluation of samarium (III) phosphate [{sup 153}Sm] colloid (SMPC) for possible therapeutic use."
United Kingdom.
https://doi.org/10.1016/S0969-8051(00)00097-4.
@misc{etde_20271949,
title = {Preparation and evaluation of samarium (III) phosphate [{sup 153}Sm] colloid (SMPC) for possible therapeutic use}
author = {Prabhakar, G, Joshi, Sangeeta H, Ranganatha, D K, Umamaheswari, S, Ananthakrishnan, M, and Ramamoorthy, N}
abstractNote = {A simple method of preparation of a new therapeutic colloid, samarium(III) phosphate-{sup 153}Sm (SMPC), is reported involving the reaction of carrier-added {sup 153}SmCl{sub 3} with phosphoric acid. Recovery of the colloid was accomplished by dialysis leading to purification and a radiochemical (RC) yield of more than 90%. The RC purity of purified colloid formulated in isotonic phosphate buffer was more than 99% as assessed by paper chromatography. The product retained its RC purity throughout the period of stability study of 7 days. Complete retention of radioactivity instilled in the rabbit knee joint was observed over the study period of 6 days, with radioactivity in the blood being indistinguishable from the natural background activity. Ninety-six percent of colloidal particles were in the size range of 0.3-2 {mu}m. The promising results demonstrated warrant further studies on SMPC for assessing the suitability for therapy.}
doi = {10.1016/S0969-8051(00)00097-4}
journal = []
issue = {4}
volume = {27}
journal type = {AC}
place = {United Kingdom}
year = {2000}
month = {May}
}
title = {Preparation and evaluation of samarium (III) phosphate [{sup 153}Sm] colloid (SMPC) for possible therapeutic use}
author = {Prabhakar, G, Joshi, Sangeeta H, Ranganatha, D K, Umamaheswari, S, Ananthakrishnan, M, and Ramamoorthy, N}
abstractNote = {A simple method of preparation of a new therapeutic colloid, samarium(III) phosphate-{sup 153}Sm (SMPC), is reported involving the reaction of carrier-added {sup 153}SmCl{sub 3} with phosphoric acid. Recovery of the colloid was accomplished by dialysis leading to purification and a radiochemical (RC) yield of more than 90%. The RC purity of purified colloid formulated in isotonic phosphate buffer was more than 99% as assessed by paper chromatography. The product retained its RC purity throughout the period of stability study of 7 days. Complete retention of radioactivity instilled in the rabbit knee joint was observed over the study period of 6 days, with radioactivity in the blood being indistinguishable from the natural background activity. Ninety-six percent of colloidal particles were in the size range of 0.3-2 {mu}m. The promising results demonstrated warrant further studies on SMPC for assessing the suitability for therapy.}
doi = {10.1016/S0969-8051(00)00097-4}
journal = []
issue = {4}
volume = {27}
journal type = {AC}
place = {United Kingdom}
year = {2000}
month = {May}
}