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Effects of enriched uranium on developing brain damage of neonatal rats

Abstract

The model of irradiation-induced brain damage in vivo was settled first of all. The micro-auto-radiographic tracing showed that when the rat's brain at postnatal day after lateral ventricle injection with enriched uranium {sup 235}U the radionuclides were mainly accumulated in the nucleus. At the same time autoradiographic tracks appeared in the cytoplasm and interval between cells. The effects of cerebrum exposure to alpha irradiation by enriched uranium on somatic growth and neuro-behavior development of neonatal rats were examined by determination of multiple parameters. In the growth and development of the neonatal rat's cerebrum exposure to enriched uranium, the somatic growth such as body weight and brain weight increase was lower significantly. The data indicated that the neonatal wistar rats having cerebrum exposure to alpha irradiation by enriched uranium showed delayed growth and abnormal neuro-behavior. The changes of neuron specific enolase (NSE), interleukin-1 {beta} (IL- {beta}), superoxide dismutase (SOD), and endothelin (ET) in cerebellum, cerebral cortex, hippocampus, diencephalons of the rat brain after expose to alpha irradiation by enriched uranium were examined with radioimmunoassay. The results showed that SOD and ET can be elevated by the low dose irradiation of enriched uranium, and can be distinctly inhibited by the high dose.  More>>
Authors:
Guixiong, Gu; Shoupeng, Zhu; Liuyi, Wang; Shuqin, Yang; Lingli, Zhu [1] 
  1. Suzhou Medical College, Suzhou (China)
Publication Date:
Apr 01, 2001
Product Type:
Technical Report
Report Number:
CNIC-01488; SMC-0160
Resource Relation:
Other Information: Data in PDF format: Acrobat Reader for Windows 9x; PBD: Apr 2001; Related Information: China Nuclear Science and Technology Report, CNIC/CD/2001-1
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; ALPHA PARTICLES; AUTORADIOGRAPHY; BRAIN; ENDOTHELIUM; ENOLS; ENRICHED URANIUM; IN VIVO; NEONATES; NERVE CELLS; RADIATION INJURIES; RADIOIMMUNOASSAY; RADIOSENSITIVITY; RATS; SOMATIC MUTATIONS; SUPEROXIDE DISMUTASE
OSTI ID:
20244411
Research Organizations:
China Nuclear Information Centre, Beijing (China)
Country of Origin:
China
Language:
Chinese
Other Identifying Numbers:
Other: ISBN 7-89999-317-2; TRN: CN0201057017113
Availability:
Available from INIS in electronic form
Submitting Site:
INIS
Size:
17 pages
Announcement Date:

Citation Formats

Guixiong, Gu, Shoupeng, Zhu, Liuyi, Wang, Shuqin, Yang, and Lingli, Zhu. Effects of enriched uranium on developing brain damage of neonatal rats. China: N. p., 2001. Web.
Guixiong, Gu, Shoupeng, Zhu, Liuyi, Wang, Shuqin, Yang, & Lingli, Zhu. Effects of enriched uranium on developing brain damage of neonatal rats. China.
Guixiong, Gu, Shoupeng, Zhu, Liuyi, Wang, Shuqin, Yang, and Lingli, Zhu. 2001. "Effects of enriched uranium on developing brain damage of neonatal rats." China.
@misc{etde_20244411,
title = {Effects of enriched uranium on developing brain damage of neonatal rats}
author = {Guixiong, Gu, Shoupeng, Zhu, Liuyi, Wang, Shuqin, Yang, and Lingli, Zhu}
abstractNote = {The model of irradiation-induced brain damage in vivo was settled first of all. The micro-auto-radiographic tracing showed that when the rat's brain at postnatal day after lateral ventricle injection with enriched uranium {sup 235}U the radionuclides were mainly accumulated in the nucleus. At the same time autoradiographic tracks appeared in the cytoplasm and interval between cells. The effects of cerebrum exposure to alpha irradiation by enriched uranium on somatic growth and neuro-behavior development of neonatal rats were examined by determination of multiple parameters. In the growth and development of the neonatal rat's cerebrum exposure to enriched uranium, the somatic growth such as body weight and brain weight increase was lower significantly. The data indicated that the neonatal wistar rats having cerebrum exposure to alpha irradiation by enriched uranium showed delayed growth and abnormal neuro-behavior. The changes of neuron specific enolase (NSE), interleukin-1 {beta} (IL- {beta}), superoxide dismutase (SOD), and endothelin (ET) in cerebellum, cerebral cortex, hippocampus, diencephalons of the rat brain after expose to alpha irradiation by enriched uranium were examined with radioimmunoassay. The results showed that SOD and ET can be elevated by the low dose irradiation of enriched uranium, and can be distinctly inhibited by the high dose. The data in view of biochemistry indicated firstly that alpha irradiation from enriched uranium on the developing brain damage of neonatal rats were of sensibility, fragility and compensation in nervous cells.}
place = {China}
year = {2001}
month = {Apr}
}