Abstract
Pepsinogen I and Pepsinogen II (PG I and PG II) were purified from human gastric mucosa using DE-52 anion exchange chromatography, Gel filtration HPLC and Q-2 anion exchange fast pressure chromatography. The antiserums against at both PG I and PG II were established respectively by preparing {sup 125}I-PG I and {sup 125}I-PG II using the chloramine-T method. Serum Pepsinogen I and II levels were measured by RIA in 190 healthy controls and other gastric diseases. The results were analyzed by statistics method. Compared with healthy controls, the serum PG I levels of duodenal ulcer patients and gastric ulcer were significantly higher. The serum PG I levels of gastritis patients were significantly lower and the serum PG I levels and PG I/PG II ratio of gastric cancer patients were much more lower. After total gastrectomy, the serum PG I and PG II levels of patients with recurrence of gastric cancer were significantly higher than those without recurrence. The changes of serum PG I and PG II levels are valuable for the diagnosis of gastric cancer and detecting the recurrence of gastric cancer after total gastrectomy.
Mengjun, Jiang;
Zhijian, Xiao;
Xizhen, Yang;
Xuquan, Huang;
Huixin, Yu;
Rongjun, Zhang;
Yonghui, Tao;
Lianfen, Zhang;
Gangming, Cai;
Cheng, Tan;
Ye, Xiao;
Jian, Jin;
Bocheng, Wang
[1]
- Jiangsu Inst. of Nuclear Medicine, Wuxi (China). State Key Laboratory of Nuclear Medicine
Citation Formats
Mengjun, Jiang, Zhijian, Xiao, Xizhen, Yang, Xuquan, Huang, Huixin, Yu, Rongjun, Zhang, Yonghui, Tao, Lianfen, Zhang, Gangming, Cai, Cheng, Tan, Ye, Xiao, Jian, Jin, and Bocheng, Wang.
Correlation between pepsinogens and gastric cancer.
China: N. p.,
2001.
Web.
Mengjun, Jiang, Zhijian, Xiao, Xizhen, Yang, Xuquan, Huang, Huixin, Yu, Rongjun, Zhang, Yonghui, Tao, Lianfen, Zhang, Gangming, Cai, Cheng, Tan, Ye, Xiao, Jian, Jin, & Bocheng, Wang.
Correlation between pepsinogens and gastric cancer.
China.
Mengjun, Jiang, Zhijian, Xiao, Xizhen, Yang, Xuquan, Huang, Huixin, Yu, Rongjun, Zhang, Yonghui, Tao, Lianfen, Zhang, Gangming, Cai, Cheng, Tan, Ye, Xiao, Jian, Jin, and Bocheng, Wang.
2001.
"Correlation between pepsinogens and gastric cancer."
China.
@misc{etde_20244407,
title = {Correlation between pepsinogens and gastric cancer}
author = {Mengjun, Jiang, Zhijian, Xiao, Xizhen, Yang, Xuquan, Huang, Huixin, Yu, Rongjun, Zhang, Yonghui, Tao, Lianfen, Zhang, Gangming, Cai, Cheng, Tan, Ye, Xiao, Jian, Jin, and Bocheng, Wang}
abstractNote = {Pepsinogen I and Pepsinogen II (PG I and PG II) were purified from human gastric mucosa using DE-52 anion exchange chromatography, Gel filtration HPLC and Q-2 anion exchange fast pressure chromatography. The antiserums against at both PG I and PG II were established respectively by preparing {sup 125}I-PG I and {sup 125}I-PG II using the chloramine-T method. Serum Pepsinogen I and II levels were measured by RIA in 190 healthy controls and other gastric diseases. The results were analyzed by statistics method. Compared with healthy controls, the serum PG I levels of duodenal ulcer patients and gastric ulcer were significantly higher. The serum PG I levels of gastritis patients were significantly lower and the serum PG I levels and PG I/PG II ratio of gastric cancer patients were much more lower. After total gastrectomy, the serum PG I and PG II levels of patients with recurrence of gastric cancer were significantly higher than those without recurrence. The changes of serum PG I and PG II levels are valuable for the diagnosis of gastric cancer and detecting the recurrence of gastric cancer after total gastrectomy.}
place = {China}
year = {2001}
month = {Apr}
}
title = {Correlation between pepsinogens and gastric cancer}
author = {Mengjun, Jiang, Zhijian, Xiao, Xizhen, Yang, Xuquan, Huang, Huixin, Yu, Rongjun, Zhang, Yonghui, Tao, Lianfen, Zhang, Gangming, Cai, Cheng, Tan, Ye, Xiao, Jian, Jin, and Bocheng, Wang}
abstractNote = {Pepsinogen I and Pepsinogen II (PG I and PG II) were purified from human gastric mucosa using DE-52 anion exchange chromatography, Gel filtration HPLC and Q-2 anion exchange fast pressure chromatography. The antiserums against at both PG I and PG II were established respectively by preparing {sup 125}I-PG I and {sup 125}I-PG II using the chloramine-T method. Serum Pepsinogen I and II levels were measured by RIA in 190 healthy controls and other gastric diseases. The results were analyzed by statistics method. Compared with healthy controls, the serum PG I levels of duodenal ulcer patients and gastric ulcer were significantly higher. The serum PG I levels of gastritis patients were significantly lower and the serum PG I levels and PG I/PG II ratio of gastric cancer patients were much more lower. After total gastrectomy, the serum PG I and PG II levels of patients with recurrence of gastric cancer were significantly higher than those without recurrence. The changes of serum PG I and PG II levels are valuable for the diagnosis of gastric cancer and detecting the recurrence of gastric cancer after total gastrectomy.}
place = {China}
year = {2001}
month = {Apr}
}