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Correlation between pepsinogens and gastric cancer

Abstract

Pepsinogen I and Pepsinogen II (PG I and PG II) were purified from human gastric mucosa using DE-52 anion exchange chromatography, Gel filtration HPLC and Q-2 anion exchange fast pressure chromatography. The antiserums against at both PG I and PG II were established respectively by preparing {sup 125}I-PG I and {sup 125}I-PG II using the chloramine-T method. Serum Pepsinogen I and II levels were measured by RIA in 190 healthy controls and other gastric diseases. The results were analyzed by statistics method. Compared with healthy controls, the serum PG I levels of duodenal ulcer patients and gastric ulcer were significantly higher. The serum PG I levels of gastritis patients were significantly lower and the serum PG I levels and PG I/PG II ratio of gastric cancer patients were much more lower. After total gastrectomy, the serum PG I and PG II levels of patients with recurrence of gastric cancer were significantly higher than those without recurrence. The changes of serum PG I and PG II levels are valuable for the diagnosis of gastric cancer and detecting the recurrence of gastric cancer after total gastrectomy.
Authors:
Mengjun, Jiang; Zhijian, Xiao; Xizhen, Yang; Xuquan, Huang; Huixin, Yu; Rongjun, Zhang; Yonghui, Tao; Lianfen, Zhang; Gangming, Cai; Cheng, Tan; Ye, Xiao; Jian, Jin; Bocheng, Wang [1] 
  1. Jiangsu Inst. of Nuclear Medicine, Wuxi (China). State Key Laboratory of Nuclear Medicine
Publication Date:
Apr 01, 2001
Product Type:
Technical Report
Report Number:
CNIC-01484; NLNM-0003
Resource Relation:
Other Information: Data in PDF format: Acrobat Reader for Windows 9x; PBD: Apr 2001; Related Information: China Nuclear Science and Technology Report, CNIC/CD/2001-1
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; DIAGNOSTIC TECHNIQUES; FILTRATION; GASTRECTOMY; IMMUNE SERUMS; IODINE 125; ION EXCHANGE CHROMATOGRAPHY; LABELLED COMPOUNDS; MUCOUS MEMBRANES; NEOPLASMS; PATIENTS; PEPSIN; RADIOIMMUNOASSAY; STATISTICS; STOMACH
OSTI ID:
20244407
Research Organizations:
China Nuclear Information Centre, Beijing (China)
Country of Origin:
China
Language:
Chinese
Other Identifying Numbers:
Other: ISBN 7-89999-317-2; TRN: CN0201053017109
Availability:
Available from INIS in electronic form
Submitting Site:
INIS
Size:
13 pages
Announcement Date:

Citation Formats

Mengjun, Jiang, Zhijian, Xiao, Xizhen, Yang, Xuquan, Huang, Huixin, Yu, Rongjun, Zhang, Yonghui, Tao, Lianfen, Zhang, Gangming, Cai, Cheng, Tan, Ye, Xiao, Jian, Jin, and Bocheng, Wang. Correlation between pepsinogens and gastric cancer. China: N. p., 2001. Web.
Mengjun, Jiang, Zhijian, Xiao, Xizhen, Yang, Xuquan, Huang, Huixin, Yu, Rongjun, Zhang, Yonghui, Tao, Lianfen, Zhang, Gangming, Cai, Cheng, Tan, Ye, Xiao, Jian, Jin, & Bocheng, Wang. Correlation between pepsinogens and gastric cancer. China.
Mengjun, Jiang, Zhijian, Xiao, Xizhen, Yang, Xuquan, Huang, Huixin, Yu, Rongjun, Zhang, Yonghui, Tao, Lianfen, Zhang, Gangming, Cai, Cheng, Tan, Ye, Xiao, Jian, Jin, and Bocheng, Wang. 2001. "Correlation between pepsinogens and gastric cancer." China.
@misc{etde_20244407,
title = {Correlation between pepsinogens and gastric cancer}
author = {Mengjun, Jiang, Zhijian, Xiao, Xizhen, Yang, Xuquan, Huang, Huixin, Yu, Rongjun, Zhang, Yonghui, Tao, Lianfen, Zhang, Gangming, Cai, Cheng, Tan, Ye, Xiao, Jian, Jin, and Bocheng, Wang}
abstractNote = {Pepsinogen I and Pepsinogen II (PG I and PG II) were purified from human gastric mucosa using DE-52 anion exchange chromatography, Gel filtration HPLC and Q-2 anion exchange fast pressure chromatography. The antiserums against at both PG I and PG II were established respectively by preparing {sup 125}I-PG I and {sup 125}I-PG II using the chloramine-T method. Serum Pepsinogen I and II levels were measured by RIA in 190 healthy controls and other gastric diseases. The results were analyzed by statistics method. Compared with healthy controls, the serum PG I levels of duodenal ulcer patients and gastric ulcer were significantly higher. The serum PG I levels of gastritis patients were significantly lower and the serum PG I levels and PG I/PG II ratio of gastric cancer patients were much more lower. After total gastrectomy, the serum PG I and PG II levels of patients with recurrence of gastric cancer were significantly higher than those without recurrence. The changes of serum PG I and PG II levels are valuable for the diagnosis of gastric cancer and detecting the recurrence of gastric cancer after total gastrectomy.}
place = {China}
year = {2001}
month = {Apr}
}