Abstract
It is known that the deuterium/hydrogen mass ratio is the largest of stable isotopes of the same element, causing differences in the physical and chemical behaviour between the two hydrogen isotopes. The possible role of naturally occurring deuterium - whose concentration is over 16 mmol/l in surface water, 12-14 mmol/l in living organisms - in biological systems was first investigated in the early 90s. The results revealed that deuterium depleted water (DDW): i) inhibits cell proliferation of different cell lines in vitro (MDA and MCF-7: human breast, PC-3: human prostate, M14: human melanoma, HT-29: human colon, L{sub 929}: mouse fibroblast, A4: murine haemopoietic); ii) as drinking water causes partial or complete tumour regression in xenotransplanted mice (MDA, MCF-7, PC-3); iii) can induce complete or partial tumour regression in dogs and cats with different tumours; iv) induced apoptosis in vitro and vivo; v) has a significant influence on the e-mye, Ha-ras and p53 genes by reducing their expression; vi) shows efficacy in Phase II double blind clinical trial with human prostate cancer. It is generally accepted that the earliest event in the response of mammalian cells to mitogens is the elevation of pH{sub i}, which may be the proliferative trigger. It
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Somlyai, G;
[1]
Jancso, G;
Jakli, Gy;
[2]
Berkenyi, T;
[3]
Laskay, G;
[4]
Gyoengyi, Z
[5]
- HYD Ltd, for Research and Development, Budapest (Hungary)
- Central Research Institute for Physics, Atomic Energy Research Institute, Budapest (Hungary)
- Alpha-Vet Veterinary Hospital, Szekesfehervar (Hungary)
- Department of Botany, University of Szeged, Szeged (Hungary)
- Department of Public Health, University Medical School of Pecs, Pecs (Hungary)
Citation Formats
Somlyai, G, Jancso, G, Jakli, Gy, Berkenyi, T, Laskay, G, and Gyoengyi, Z.
The biological effects of deuterium depletion. A possible new tool in cancer therapy.
Romania: N. p.,
2000.
Web.
Somlyai, G, Jancso, G, Jakli, Gy, Berkenyi, T, Laskay, G, & Gyoengyi, Z.
The biological effects of deuterium depletion. A possible new tool in cancer therapy.
Romania.
Somlyai, G, Jancso, G, Jakli, Gy, Berkenyi, T, Laskay, G, and Gyoengyi, Z.
2000.
"The biological effects of deuterium depletion. A possible new tool in cancer therapy."
Romania.
@misc{etde_20240457,
title = {The biological effects of deuterium depletion. A possible new tool in cancer therapy}
author = {Somlyai, G, Jancso, G, Jakli, Gy, Berkenyi, T, Laskay, G, and Gyoengyi, Z}
abstractNote = {It is known that the deuterium/hydrogen mass ratio is the largest of stable isotopes of the same element, causing differences in the physical and chemical behaviour between the two hydrogen isotopes. The possible role of naturally occurring deuterium - whose concentration is over 16 mmol/l in surface water, 12-14 mmol/l in living organisms - in biological systems was first investigated in the early 90s. The results revealed that deuterium depleted water (DDW): i) inhibits cell proliferation of different cell lines in vitro (MDA and MCF-7: human breast, PC-3: human prostate, M14: human melanoma, HT-29: human colon, L{sub 929}: mouse fibroblast, A4: murine haemopoietic); ii) as drinking water causes partial or complete tumour regression in xenotransplanted mice (MDA, MCF-7, PC-3); iii) can induce complete or partial tumour regression in dogs and cats with different tumours; iv) induced apoptosis in vitro and vivo; v) has a significant influence on the e-mye, Ha-ras and p53 genes by reducing their expression; vi) shows efficacy in Phase II double blind clinical trial with human prostate cancer. It is generally accepted that the earliest event in the response of mammalian cells to mitogens is the elevation of pH{sub i}, which may be the proliferative trigger. It is also known that the binding site for protons to be transported by plasma membrane H{sup 4}-ATPasc of yeast does not accept deuterons with the same case as H{sup 4} or perhaps not at all. It is therefore reasonable to assume that when the cell eliminates the H{sup 4} to govern the pH{sub i} by activating the Na{sup +}/H{sup 4} antiport system the D/H ratio increases in the intracellular space. We suggest that the cell cycle regulating system is somehow able to recognize the change in the D/H ratio and when this ratio reaches a certain threshold this will trigger the molecular mechanism which causes the cell to enter the S phase. The decrease of D concentration caused by DDW can interfere with the signal transduction pathways thus leading to tumour regression. We suggest that the application of DDW may open new possibilities in cancer therapy by offering a direct intervention in the processes of cell cycle regulation. (authors)}
place = {Romania}
year = {2000}
month = {Jul}
}
title = {The biological effects of deuterium depletion. A possible new tool in cancer therapy}
author = {Somlyai, G, Jancso, G, Jakli, Gy, Berkenyi, T, Laskay, G, and Gyoengyi, Z}
abstractNote = {It is known that the deuterium/hydrogen mass ratio is the largest of stable isotopes of the same element, causing differences in the physical and chemical behaviour between the two hydrogen isotopes. The possible role of naturally occurring deuterium - whose concentration is over 16 mmol/l in surface water, 12-14 mmol/l in living organisms - in biological systems was first investigated in the early 90s. The results revealed that deuterium depleted water (DDW): i) inhibits cell proliferation of different cell lines in vitro (MDA and MCF-7: human breast, PC-3: human prostate, M14: human melanoma, HT-29: human colon, L{sub 929}: mouse fibroblast, A4: murine haemopoietic); ii) as drinking water causes partial or complete tumour regression in xenotransplanted mice (MDA, MCF-7, PC-3); iii) can induce complete or partial tumour regression in dogs and cats with different tumours; iv) induced apoptosis in vitro and vivo; v) has a significant influence on the e-mye, Ha-ras and p53 genes by reducing their expression; vi) shows efficacy in Phase II double blind clinical trial with human prostate cancer. It is generally accepted that the earliest event in the response of mammalian cells to mitogens is the elevation of pH{sub i}, which may be the proliferative trigger. It is also known that the binding site for protons to be transported by plasma membrane H{sup 4}-ATPasc of yeast does not accept deuterons with the same case as H{sup 4} or perhaps not at all. It is therefore reasonable to assume that when the cell eliminates the H{sup 4} to govern the pH{sub i} by activating the Na{sup +}/H{sup 4} antiport system the D/H ratio increases in the intracellular space. We suggest that the cell cycle regulating system is somehow able to recognize the change in the D/H ratio and when this ratio reaches a certain threshold this will trigger the molecular mechanism which causes the cell to enter the S phase. The decrease of D concentration caused by DDW can interfere with the signal transduction pathways thus leading to tumour regression. We suggest that the application of DDW may open new possibilities in cancer therapy by offering a direct intervention in the processes of cell cycle regulation. (authors)}
place = {Romania}
year = {2000}
month = {Jul}
}