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Functional neuroimaging and childhood autism

Journal Article:

Abstract

Childhood autism is now widely viewed as being of developmental neurobiological origin. Yet, localised structural and functional brain correlates of autism have to be established. Structural brain-imaging studies performed in autistic patients have reported abnormalities such as increased total brain volume and cerebellar abnormalities. However, none of these abnormalities fully account for the full range of autistic symptoms. Functional brain imaging, such as positron emission tomography (PET), single photon emission computed tomography (SPECT) and functional MRI (fMRI) have added a new perspective to the study of normal and pathological brain functions. In autism, functional studies have been performed at rest or during activation. However, first-generation functional imaging devices were not sensitive enough to detect any consistent dysfunction. Recently, with improved technology, two independent groups have reported bilateral hypoperfusion of the temporal lobes in autistic children. In addition, activation studies, using perceptive and cognitive paradigms, have shown an abnormal pattern of cortical activation in autistic patients. These results suggest that different connections between particular cortical regions could exist in autism. The purpose of this review is to present the main results of rest and activation studies performed in autism. (orig.)
Authors:
Boddaert, Nathalie; [1]  Service Hospitalier Frederic Joliot, DRM, DSV, CEA, Orsay (France)]; Zilbovicius, Monica; [2]  INSERM, Tours [3] 
  1. Service de Radiologie Pediatrique, Necker-Enfants Malades Hospital, Paris (France)
  2. Service Hospitalier Frederic Joliot, DRM, DSV, CEA, Orsay (France)
  3. France
Publication Date:
Jan 01, 2002
Product Type:
Journal Article
Report Number:
10.1007/s00247-001-0570-x
Resource Relation:
Journal Name: Pediatric Radiology; Journal Volume: 32; Journal Issue: 1; Other Information: PBD: Jan 2002
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; MENTAL DISORDERS; NEUROLOGY; NERVOUS SYSTEM DISEASES; NMR IMAGING; SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY; BRAIN; BEHAVIOR
OSTI ID:
20235888
Country of Origin:
Germany
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 0301-0449; PDRYA5; TRN: DE02F3200
Submitting Site:
DEN
Size:
page(s) 1-7
Announcement Date:

Journal Article:

Citation Formats

Boddaert, Nathalie, Service Hospitalier Frederic Joliot, DRM, DSV, CEA, Orsay (France)], Zilbovicius, Monica, and INSERM, Tours. Functional neuroimaging and childhood autism. Germany: N. p., 2002. Web.
Boddaert, Nathalie, Service Hospitalier Frederic Joliot, DRM, DSV, CEA, Orsay (France)], Zilbovicius, Monica, & INSERM, Tours. Functional neuroimaging and childhood autism. Germany.
Boddaert, Nathalie, Service Hospitalier Frederic Joliot, DRM, DSV, CEA, Orsay (France)], Zilbovicius, Monica, and INSERM, Tours. 2002. "Functional neuroimaging and childhood autism." Germany.
@misc{etde_20235888,
title = {Functional neuroimaging and childhood autism}
author = {Boddaert, Nathalie, Service Hospitalier Frederic Joliot, DRM, DSV, CEA, Orsay (France)], Zilbovicius, Monica, and INSERM, Tours}
abstractNote = {Childhood autism is now widely viewed as being of developmental neurobiological origin. Yet, localised structural and functional brain correlates of autism have to be established. Structural brain-imaging studies performed in autistic patients have reported abnormalities such as increased total brain volume and cerebellar abnormalities. However, none of these abnormalities fully account for the full range of autistic symptoms. Functional brain imaging, such as positron emission tomography (PET), single photon emission computed tomography (SPECT) and functional MRI (fMRI) have added a new perspective to the study of normal and pathological brain functions. In autism, functional studies have been performed at rest or during activation. However, first-generation functional imaging devices were not sensitive enough to detect any consistent dysfunction. Recently, with improved technology, two independent groups have reported bilateral hypoperfusion of the temporal lobes in autistic children. In addition, activation studies, using perceptive and cognitive paradigms, have shown an abnormal pattern of cortical activation in autistic patients. These results suggest that different connections between particular cortical regions could exist in autism. The purpose of this review is to present the main results of rest and activation studies performed in autism. (orig.)}
journal = {Pediatric Radiology}
issue = {1}
volume = {32}
journal type = {AC}
place = {Germany}
year = {2002}
month = {Jan}
}