Abstract
Judging that in the beginning of the toxicity test, the necessary information/knowledge are acquired not by using animal itself but only by using liver system (hepatocyte), the development was proceeded with of the hepatocyte chip substituting for the animal experiment. Studies were made in the following five fields: 1) design of functional matrices; 2) development of the pharmacological assessment technology; 3) development of cell sensing technology/biosensor fabrication; 4) study of a possibility and the limit of cell patterning technology; 5) survey of the market scale. In 1), studies were made of the establishment of the 3D culture method for hepatocyte and the construction of hepatocyte models for medicine assessment using pieces of liver. In the latter, by including capsule using the sugar introduced with galactose residue which is special sugar of hepatocyte to alginic acid and chitosan which are natural polymer and also hepatocyte isolated into sponge, aggregate was formed, and its use as a medicine assessment use liver model was tried to be made. (NEDO)
Citation Formats
None.
FY 2000 report on the results of the regional consortium R and D project - Regional new technology creation R and D. First year report. R and D of medicine toxicity assessment use hepatocyte chip; 2000 nendo chiiki consortium kenkyu kaihatsu jigyo. Chiiki consortium kenkyu kaihatsu / chiiki shingijutsu soshutsu kenkyu kaihatsu. Dokubutsu dokusei hyokayo kansaibo chip no kenkyu kaihatsu (dai 1 nendo) seika hokokusho.
Japan: N. p.,
2001.
Web.
None.
FY 2000 report on the results of the regional consortium R and D project - Regional new technology creation R and D. First year report. R and D of medicine toxicity assessment use hepatocyte chip; 2000 nendo chiiki consortium kenkyu kaihatsu jigyo. Chiiki consortium kenkyu kaihatsu / chiiki shingijutsu soshutsu kenkyu kaihatsu. Dokubutsu dokusei hyokayo kansaibo chip no kenkyu kaihatsu (dai 1 nendo) seika hokokusho.
Japan.
None.
2001.
"FY 2000 report on the results of the regional consortium R and D project - Regional new technology creation R and D. First year report. R and D of medicine toxicity assessment use hepatocyte chip; 2000 nendo chiiki consortium kenkyu kaihatsu jigyo. Chiiki consortium kenkyu kaihatsu / chiiki shingijutsu soshutsu kenkyu kaihatsu. Dokubutsu dokusei hyokayo kansaibo chip no kenkyu kaihatsu (dai 1 nendo) seika hokokusho."
Japan.
@misc{etde_20203000,
title = {FY 2000 report on the results of the regional consortium R and D project - Regional new technology creation R and D. First year report. R and D of medicine toxicity assessment use hepatocyte chip; 2000 nendo chiiki consortium kenkyu kaihatsu jigyo. Chiiki consortium kenkyu kaihatsu / chiiki shingijutsu soshutsu kenkyu kaihatsu. Dokubutsu dokusei hyokayo kansaibo chip no kenkyu kaihatsu (dai 1 nendo) seika hokokusho}
author = {None}
abstractNote = {Judging that in the beginning of the toxicity test, the necessary information/knowledge are acquired not by using animal itself but only by using liver system (hepatocyte), the development was proceeded with of the hepatocyte chip substituting for the animal experiment. Studies were made in the following five fields: 1) design of functional matrices; 2) development of the pharmacological assessment technology; 3) development of cell sensing technology/biosensor fabrication; 4) study of a possibility and the limit of cell patterning technology; 5) survey of the market scale. In 1), studies were made of the establishment of the 3D culture method for hepatocyte and the construction of hepatocyte models for medicine assessment using pieces of liver. In the latter, by including capsule using the sugar introduced with galactose residue which is special sugar of hepatocyte to alginic acid and chitosan which are natural polymer and also hepatocyte isolated into sponge, aggregate was formed, and its use as a medicine assessment use liver model was tried to be made. (NEDO)}
place = {Japan}
year = {2001}
month = {Mar}
}
title = {FY 2000 report on the results of the regional consortium R and D project - Regional new technology creation R and D. First year report. R and D of medicine toxicity assessment use hepatocyte chip; 2000 nendo chiiki consortium kenkyu kaihatsu jigyo. Chiiki consortium kenkyu kaihatsu / chiiki shingijutsu soshutsu kenkyu kaihatsu. Dokubutsu dokusei hyokayo kansaibo chip no kenkyu kaihatsu (dai 1 nendo) seika hokokusho}
author = {None}
abstractNote = {Judging that in the beginning of the toxicity test, the necessary information/knowledge are acquired not by using animal itself but only by using liver system (hepatocyte), the development was proceeded with of the hepatocyte chip substituting for the animal experiment. Studies were made in the following five fields: 1) design of functional matrices; 2) development of the pharmacological assessment technology; 3) development of cell sensing technology/biosensor fabrication; 4) study of a possibility and the limit of cell patterning technology; 5) survey of the market scale. In 1), studies were made of the establishment of the 3D culture method for hepatocyte and the construction of hepatocyte models for medicine assessment using pieces of liver. In the latter, by including capsule using the sugar introduced with galactose residue which is special sugar of hepatocyte to alginic acid and chitosan which are natural polymer and also hepatocyte isolated into sponge, aggregate was formed, and its use as a medicine assessment use liver model was tried to be made. (NEDO)}
place = {Japan}
year = {2001}
month = {Mar}
}