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Recent developments and future directions for stable isotope applications in nutrition research. Report of a consultants meeting

Abstract

The International Atomic Energy Agency (IAEA) at its Headquarters in Vienna convened a consultants meeting to provide the Agency with an overview of the current status of isotopic techniques in nutritional science with respect to both methodology and applications. The main objectives were: To assess the practice of stable isotope methodologies in human nutrition research; To explore high quality stable isotope spikes for use in humans; To standardise the mathematical approaches to evaluate mass spectrometric data when using stable isotope labels within metabolic studies; To identify new strategies for improving sensitivity of nutrition monitoring techniques for use in projects in nutrition. This exercise was conducted to also identify strengths and weaknesses of methodologies currently used in IAEA funded research (CRPs and Technical Cooperation Projects) and to see how they can be improved for the general user, and to provide a basis for the assessment of outcomes delivered by collaborating laboratories in IAEA funded studies. The consultants reviewed the methods relating to the measurement of energy expenditure and noted that the analytical methodologies had changed substantially and that there was further refinement to data fitting and the calculation of uncertainties. They also felt that a repeat of a comparison of laboratory  More>>
Authors:
"NONE"
Publication Date:
Jul 01, 2001
Product Type:
Technical Report
Report Number:
NAHRES-64
Reference Number:
EDB-01:099104
Resource Relation:
Conference: IAEA consultants meeting on recent developments and future directions for stable isotope applications in nutrition research, Vienna (Austria), 4-8 Dec 2000; Other Information: Refs, 2 figs; PBD: 2001
Subject:
60 APPLIED LIFE SCIENCES; BODY COMPOSITION; CARBON 13; CARBOXYLIC ACIDS; CAROTENOIDS; DEUTERIUM; FOOD; ISOTOPE APPLICATIONS; MASS SPECTROSCOPY; NITROGEN 15; NUTRIENTS; NUTRITIONAL DEFICIENCY; OSTEOPOROSIS; OXYGEN 18; PROTEINS; QUALITY CONTROL; VITAMIN A
OSTI ID:
20202791
Research Organizations:
International Atomic Energy Agency, Section of Nutritional and Health-Related Environmental Studies, Vienna (Austria)
Country of Origin:
IAEA
Language:
English
Other Identifying Numbers:
TRN: XA0102840053355
Availability:
Available from INIS in electronic form
Submitting Site:
INIS
Size:
30 pages
Announcement Date:

Citation Formats

Recent developments and future directions for stable isotope applications in nutrition research. Report of a consultants meeting. IAEA: N. p., 2001. Web.
Recent developments and future directions for stable isotope applications in nutrition research. Report of a consultants meeting. IAEA.
2001. "Recent developments and future directions for stable isotope applications in nutrition research. Report of a consultants meeting." IAEA.
@misc{etde_20202791,
title = {Recent developments and future directions for stable isotope applications in nutrition research. Report of a consultants meeting}
abstractNote = {The International Atomic Energy Agency (IAEA) at its Headquarters in Vienna convened a consultants meeting to provide the Agency with an overview of the current status of isotopic techniques in nutritional science with respect to both methodology and applications. The main objectives were: To assess the practice of stable isotope methodologies in human nutrition research; To explore high quality stable isotope spikes for use in humans; To standardise the mathematical approaches to evaluate mass spectrometric data when using stable isotope labels within metabolic studies; To identify new strategies for improving sensitivity of nutrition monitoring techniques for use in projects in nutrition. This exercise was conducted to also identify strengths and weaknesses of methodologies currently used in IAEA funded research (CRPs and Technical Cooperation Projects) and to see how they can be improved for the general user, and to provide a basis for the assessment of outcomes delivered by collaborating laboratories in IAEA funded studies. The consultants reviewed the methods relating to the measurement of energy expenditure and noted that the analytical methodologies had changed substantially and that there was further refinement to data fitting and the calculation of uncertainties. They also felt that a repeat of a comparison of laboratory performances with a dilution series similar to the one carried out earlier should be performed for quality control. Other methods using labelled isotopes {sup 13}C and {sup 2}H were also discussed. The meeting noted that it was IAEA's intention to support the development of compound specific reference materials for {sup 2}H, {sup 13}C, {sup 15}N and {sup 18}O. Contrary to light isotope techniques where attempts have been made in the past towards standardization, in particular by IAEA and Stable Isotopes in Gastroenterology and Nutrition (SIGN) harmonization of techniques between laboratories is unsatisfactory for the minerals and trace elements. It was decided that considering the future expansion of stable isotope techniques in mineral and trace element nutrition research, ensuring comparability of results and improving data quality should be given high priority along with the still existent need to develop, evaluate and validate new techniques. This refers, in particular, to the IAEA which plays a leading role in the dissemination of these techniques, especially in the developing world. As multiple actions are required, emerging issues are briefly discussed in order of priority. Interactions between dietary components and/or multiple micronutrients and trace elements in deficiency states and their impact on human health have been discussed in some detail. The risk of osteoporosis in the elderly in countries is becoming a significant problem, associated in part with changes in dietary patterns, declines in physical activity, and increases in life expectancy. It was agreed that efforts to identify country specific etiological factors associated with the development of osteoporosis should continue. Finally, the role of isotopic techniques in the development of biomarkers to validate intakes of protein, fatty acids, carotenoids and vitamin A, certain inorganic nutrients, as well as energy intakes was also briefly discussed.}
place = {IAEA}
year = {2001}
month = {Jul}
}