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Protective effects of several plant polyphenols against chromosomal damage induced in vivo by X-rays. Comparative study versus diosmin and rutin

Abstract

Protective effects of grape (Vitis vinifera) seed (GSE), Citrus spp. fruits (CE) and olive (Olea europaea L.) leaf (OL) extracts, the flavonoids diosmin and rutin, widely used as pharmaceuticals, and dimethylsulphoxide (DMSO) against chromosomal damage induced by X-rays were determined by using the micronucleus test for anticlastogenic activity. The reduction of the frequency of micronucleated polychromatic erythrocytes (MnPCEs) in bone marrow of mouse exposed to X-rays was examined. The most effective compounds were, in order: GSE {approx} CE > rutin {approx} DMSO {approx} OL > diosmin. These results suggest a correlation between the antioxidant and anticlastogenic activity of these polyphenolic extracts. (author)
Authors:
Alcaraz, M; Rosa, B; [1]  Castillo, J; Benavente-Garcia, O; Lorente, J; [2]  Vicente, V; [3]  Canteras, M [4] 
  1. Radiology and Physical Medicine Department of Furfural Espanol S.A., Murcia (Spain)
  2. Research and Development Department of Furfural Espanol S.A., Murcia (Spain)
  3. Pathology Department of Furfural Espanol S.A., Murcia (Spain)
  4. Biostatistical Department, Faculty of Medicine, University of Murcia, Murcia (Spain)
Publication Date:
Mar 01, 2001
Product Type:
Conference
Report Number:
IAEA-CSP-7/P; IAEA-CN-85-154
Reference Number:
EDB-01:078383
Resource Relation:
Conference: International conference on radiological protection of patients in diagnostic and interventional radiology, nuclear medicine and radiotherapy, Malaga (Spain), 26-30 Mar 2001; Other Information: 8 refs, 2 figs; PBD: Mar 2001; Related Information: In: Radiological protection of patients in diagnostic and interventional radiology, nuclear medicine and radiotherapy. Contributed papers, C and S papers series no. 7/P, 916 pages.
Subject:
61 RADIATION PROTECTION AND DOSIMETRY; ANTIOXIDANTS; CITRUS; ERYTHROCYTES; FLAVINES; GRAPES; OLIVES; RADIATION PROTECTION; RADIOPHARMACEUTICALS; RADIOPROTECTIVE SUBSTANCES
OSTI ID:
20185827
Research Organizations:
International Atomic Energy Agency, Vienna (Austria); European Commission, Brussels (Belgium); Pan American Health Organization, Washington, DC (United States); World Health Organization, Geneva (Switzerland)
Country of Origin:
IAEA
Language:
English
Other Identifying Numbers:
Other: Grant 1FD97-0576; ISSN 1563-0153; TRN: XA0101760039983
Availability:
Available from INIS in electronic form
Submitting Site:
INIS
Size:
page(s) 799-802
Announcement Date:

Citation Formats

Alcaraz, M, Rosa, B, Castillo, J, Benavente-Garcia, O, Lorente, J, Vicente, V, and Canteras, M. Protective effects of several plant polyphenols against chromosomal damage induced in vivo by X-rays. Comparative study versus diosmin and rutin. IAEA: N. p., 2001. Web.
Alcaraz, M, Rosa, B, Castillo, J, Benavente-Garcia, O, Lorente, J, Vicente, V, & Canteras, M. Protective effects of several plant polyphenols against chromosomal damage induced in vivo by X-rays. Comparative study versus diosmin and rutin. IAEA.
Alcaraz, M, Rosa, B, Castillo, J, Benavente-Garcia, O, Lorente, J, Vicente, V, and Canteras, M. 2001. "Protective effects of several plant polyphenols against chromosomal damage induced in vivo by X-rays. Comparative study versus diosmin and rutin." IAEA.
@misc{etde_20185827,
title = {Protective effects of several plant polyphenols against chromosomal damage induced in vivo by X-rays. Comparative study versus diosmin and rutin}
author = {Alcaraz, M, Rosa, B, Castillo, J, Benavente-Garcia, O, Lorente, J, Vicente, V, and Canteras, M}
abstractNote = {Protective effects of grape (Vitis vinifera) seed (GSE), Citrus spp. fruits (CE) and olive (Olea europaea L.) leaf (OL) extracts, the flavonoids diosmin and rutin, widely used as pharmaceuticals, and dimethylsulphoxide (DMSO) against chromosomal damage induced by X-rays were determined by using the micronucleus test for anticlastogenic activity. The reduction of the frequency of micronucleated polychromatic erythrocytes (MnPCEs) in bone marrow of mouse exposed to X-rays was examined. The most effective compounds were, in order: GSE {approx} CE > rutin {approx} DMSO {approx} OL > diosmin. These results suggest a correlation between the antioxidant and anticlastogenic activity of these polyphenolic extracts. (author)}
place = {IAEA}
year = {2001}
month = {Mar}
}