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Regional magnetic resonance spectroscopy of the brain in autistic individuals

Abstract

We studied the variations in the concentration of metabolites with brain region and age in autistic individuals and normal controls using multiple analysis of covariance. We examined 55 autistic individuals (2-21 years old, 47 male and eight female) and 51 normal children (3 months-15 years old, 26 boys and 25 girls). Single volumes of interest were placed in the frontal, parietal and temporal region on both sides, the brain stem and cingulate gyrus. The concentration of each metabolite was quantified by the water reference method. The concentration of N-acetylaspartate in the temporal regions (Brodmann's areas 41 and 42) in the autistic individuals were significantly lower than those in the controls (P < 0.05), but concentrations in other regions were not significantly different between the autistic individuals and controls. This suggests low density or dysfunction of neurones in Brodmann's areas 41 and 42 in autistic individual, which might be related to the disturbances of the sensory speech centre (Wernicke's area) in autism. (orig.)
Authors:
Hisaoka, S; Harada, M; Nishitani, H; [1]  Mori, K [2] 
  1. Dept. of Radiology, School of Medicine, University of Tokushima (Japan)
  2. Dept. of Paediatrics, School of Medicine, University of Tokushima (Japan)
Publication Date:
Jun 01, 2001
Product Type:
Journal Article
Reference Number:
EDB-01:072790
Resource Relation:
Journal Name: Neuroradiology; Journal Volume: 43; Journal Issue: 6; Other Information: With 3 figs., 2 tabs., 5 refs.; PBD: Jun 2001
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; NMR IMAGING; BRAIN; MENTAL DISORDERS; METABOLITES; STATISTICS; NERVES
OSTI ID:
20182704
Country of Origin:
Germany
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 0028-3940; NRDYAB; TRN: DE01FA048
Submitting Site:
DEN
Size:
page(s) 496-498
Announcement Date:

Citation Formats

Hisaoka, S, Harada, M, Nishitani, H, and Mori, K. Regional magnetic resonance spectroscopy of the brain in autistic individuals. Germany: N. p., 2001. Web. doi:10.1007/s002340000520.
Hisaoka, S, Harada, M, Nishitani, H, & Mori, K. Regional magnetic resonance spectroscopy of the brain in autistic individuals. Germany. doi:10.1007/s002340000520.
Hisaoka, S, Harada, M, Nishitani, H, and Mori, K. 2001. "Regional magnetic resonance spectroscopy of the brain in autistic individuals." Germany. doi:10.1007/s002340000520. https://www.osti.gov/servlets/purl/10.1007/s002340000520.
@misc{etde_20182704,
title = {Regional magnetic resonance spectroscopy of the brain in autistic individuals}
author = {Hisaoka, S, Harada, M, Nishitani, H, and Mori, K}
abstractNote = {We studied the variations in the concentration of metabolites with brain region and age in autistic individuals and normal controls using multiple analysis of covariance. We examined 55 autistic individuals (2-21 years old, 47 male and eight female) and 51 normal children (3 months-15 years old, 26 boys and 25 girls). Single volumes of interest were placed in the frontal, parietal and temporal region on both sides, the brain stem and cingulate gyrus. The concentration of each metabolite was quantified by the water reference method. The concentration of N-acetylaspartate in the temporal regions (Brodmann's areas 41 and 42) in the autistic individuals were significantly lower than those in the controls (P < 0.05), but concentrations in other regions were not significantly different between the autistic individuals and controls. This suggests low density or dysfunction of neurones in Brodmann's areas 41 and 42 in autistic individual, which might be related to the disturbances of the sensory speech centre (Wernicke's area) in autism. (orig.)}
doi = {10.1007/s002340000520}
journal = {Neuroradiology}
issue = {6}
volume = {43}
journal type = {AC}
place = {Germany}
year = {2001}
month = {Jun}
}