You need JavaScript to view this

Fiscal 1993 report on results of R and D on innovative technology for producing advanced biomaterial; 1993 nendo senshin bio zairyo no sosei kako gijutsu no kenkyu kaihatsu seika hokokusho

Abstract

R and D was conducted on a bio-functional material that is formed by synthesizing non-natural amino acids required for the manifestation of the function, incorporating the amino acids into new bio-functional peptides to be synthesized, and fixing the peptides on a substrate such as plastics. Activities were carried out in three areas, which were (1) innovative technologies for producing functional molecules, (2) R and D on materialization technologies of functional molecules: technique of pattern formation by photochemical reaction and of fixation, and technique of preparing peptide film using vacuum thin film forming technology, and (3) comprehensive investigation and adjustment. In (1), migration stimulating activity for microphage was selected as a molecular recognition evaluation system, and on the basis of the structural analysis result of a non-peptide compound/imidazolin compound having migration stimulating activity, molecular structural design was carried out for peptides having migration stimulating activity. The result of the analysis revealed that the spatial arrangement of three phenyl nuclei and the presence of basic structures were important. Among the 22 peptides so designed, only Cbz-Phe-Phe-His-NH{sub 2} showed the migration stimulating activity. For the design, a peptide molecule design system CHARMm/QUANTA/PM3 was used. (NEDO)
Authors:
"NONE"
Publication Date:
Mar 01, 1994
Product Type:
Technical Report
Report Number:
JP-NEDO-010015466
Resource Relation:
Other Information: PBD: Mar 1994
Subject:
60 APPLIED LIFE SCIENCES; BIOLOGICAL MATERIALS; COMPOSITE MATERIALS; PEPTIDES; BIOLOGICAL FUNCTIONS; HORMONES; ENZYMES; DRUGS; SYNTHESIS; AMINO ACIDS; RECEPTORS; LIGANDS; BIOLOGY; COMPUTERIZED SIMULATION
OSTI ID:
20175176
Research Organizations:
New Energy and Industrial Technology Development Organization, Tokyo (Japan)
Country of Origin:
Japan
Language:
Japanese
Other Identifying Numbers:
TRN: JN0140076
Availability:
Available to ETDE participating countries only(see www.etde.org); commercial reproduction prohibited; OSTI as DE20175176
Submitting Site:
NEDO
Size:
74 pages
Announcement Date:

Citation Formats

Fiscal 1993 report on results of R and D on innovative technology for producing advanced biomaterial; 1993 nendo senshin bio zairyo no sosei kako gijutsu no kenkyu kaihatsu seika hokokusho. Japan: N. p., 1994. Web.
Fiscal 1993 report on results of R and D on innovative technology for producing advanced biomaterial; 1993 nendo senshin bio zairyo no sosei kako gijutsu no kenkyu kaihatsu seika hokokusho. Japan.
1994. "Fiscal 1993 report on results of R and D on innovative technology for producing advanced biomaterial; 1993 nendo senshin bio zairyo no sosei kako gijutsu no kenkyu kaihatsu seika hokokusho." Japan.
@misc{etde_20175176,
title = {Fiscal 1993 report on results of R and D on innovative technology for producing advanced biomaterial; 1993 nendo senshin bio zairyo no sosei kako gijutsu no kenkyu kaihatsu seika hokokusho}
abstractNote = {R and D was conducted on a bio-functional material that is formed by synthesizing non-natural amino acids required for the manifestation of the function, incorporating the amino acids into new bio-functional peptides to be synthesized, and fixing the peptides on a substrate such as plastics. Activities were carried out in three areas, which were (1) innovative technologies for producing functional molecules, (2) R and D on materialization technologies of functional molecules: technique of pattern formation by photochemical reaction and of fixation, and technique of preparing peptide film using vacuum thin film forming technology, and (3) comprehensive investigation and adjustment. In (1), migration stimulating activity for microphage was selected as a molecular recognition evaluation system, and on the basis of the structural analysis result of a non-peptide compound/imidazolin compound having migration stimulating activity, molecular structural design was carried out for peptides having migration stimulating activity. The result of the analysis revealed that the spatial arrangement of three phenyl nuclei and the presence of basic structures were important. Among the 22 peptides so designed, only Cbz-Phe-Phe-His-NH{sub 2} showed the migration stimulating activity. For the design, a peptide molecule design system CHARMm/QUANTA/PM3 was used. (NEDO)}
place = {Japan}
year = {1994}
month = {Mar}
}