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Preparation and dosimetry of radiotherapeutic particles for arthropaties; Preparacion y dosimetria de particulas radioterapeuticas para artropatias

Abstract

It was developed a new formulation of macro aggregates of Samarium 153 ({sup 153} Sm-MH) for the arthropaties treatment. The radio pharmaceutic was prepared by reaction of Samarium 153 chloride (SmCl{sub 3}) in aqueous environment with sodium boron hydride in NaOH 0.5 N. The microscopic analysis shown that the particles have an average size of 4% m (range 1-14 {mu} m). The velocity of sedimentation was 0.008 cm/min with high stability in vitro in human serum. The biological studies in healthy rabbits, shown that the complex is retained inside the articulation still eight days after of the administration of the radiopharmaceutical. Likewise, it is presented the data of absorbed dose in the different target organs, which was determined by thermoluminescent dosimetry (TLD) through the use of a REMCAL phantom (radiation equivalent manikin calibration). (Author)
Authors:
Gonzalez Z, M A; [1]  Ferro F, G; [2]  Rivera M, T; Azorin N, J [3] 
  1. Departamento de Medicina Nuclear, Instituto Nacional de Pediatria (Mexico)
  2. Departamento de Materiales Radiactivos, Instituto nacional de Investigaciones Nucleares, Salazar, Estado de Mexico C.P. 52045 (Mexico)
  3. Departamento de Fisica, UAM Iztapalapa, Mexico D.F. (Mexico)
Publication Date:
Jul 01, 1999
Product Type:
Conference
Report Number:
INIS-MX-563
Reference Number:
EDB-01:002440
Resource Relation:
Conference: 2. International Conference - 12. National Congress on Solid State Dosimetry, Mexico City (Mexico), 22-24 Sep 1999; Other Information: PBD: 1999
Subject:
61 RADIATION PROTECTION AND DOSIMETRY; CHEMICAL PREPARATION; DIAGRAMS; ORGANS; PARTICLE SIZE; PHANTOMS; RADIATION DOSES; RADIOPHARMACEUTICALS; RADIOTHERAPY; SAMARIUM 153; SKELETAL DISEASES; THERMOLUMINESCENT DOSIMETRY
OSTI ID:
20114907
Research Organizations:
Universidad Autonoma Metropolitana-Iztapalapa, Mexico D.F. Centro de Investigacion en Ciencia Aplicada y Tecnologia Avanzada-IPN, Mexico D.F. (Mexico)
Country of Origin:
Mexico
Language:
Spanish
Other Identifying Numbers:
TRN: MX0000337058530
Availability:
Available from INIS in electronic form
Submitting Site:
MXN
Size:
5 pages
Announcement Date:
Jan 15, 2001

Citation Formats

Gonzalez Z, M A, Ferro F, G, Rivera M, T, and Azorin N, J. Preparation and dosimetry of radiotherapeutic particles for arthropaties; Preparacion y dosimetria de particulas radioterapeuticas para artropatias. Mexico: N. p., 1999. Web.
Gonzalez Z, M A, Ferro F, G, Rivera M, T, & Azorin N, J. Preparation and dosimetry of radiotherapeutic particles for arthropaties; Preparacion y dosimetria de particulas radioterapeuticas para artropatias. Mexico.
Gonzalez Z, M A, Ferro F, G, Rivera M, T, and Azorin N, J. 1999. "Preparation and dosimetry of radiotherapeutic particles for arthropaties; Preparacion y dosimetria de particulas radioterapeuticas para artropatias." Mexico.
@misc{etde_20114907,
title = {Preparation and dosimetry of radiotherapeutic particles for arthropaties; Preparacion y dosimetria de particulas radioterapeuticas para artropatias}
author = {Gonzalez Z, M A, Ferro F, G, Rivera M, T, and Azorin N, J}
abstractNote = {It was developed a new formulation of macro aggregates of Samarium 153 ({sup 153} Sm-MH) for the arthropaties treatment. The radio pharmaceutic was prepared by reaction of Samarium 153 chloride (SmCl{sub 3}) in aqueous environment with sodium boron hydride in NaOH 0.5 N. The microscopic analysis shown that the particles have an average size of 4% m (range 1-14 {mu} m). The velocity of sedimentation was 0.008 cm/min with high stability in vitro in human serum. The biological studies in healthy rabbits, shown that the complex is retained inside the articulation still eight days after of the administration of the radiopharmaceutical. Likewise, it is presented the data of absorbed dose in the different target organs, which was determined by thermoluminescent dosimetry (TLD) through the use of a REMCAL phantom (radiation equivalent manikin calibration). (Author)}
place = {Mexico}
year = {1999}
month = {Jul}
}