Abstract
Amino acids have received significant attention in the evaluation of serotonergic and dopaminergic functions in the central nervous system. the wide distribution of {gamma}-cameras and SPECT create an increasing need for appropriated labelled radiopharmaceuticals . {sup 99m}Tc and {sup 123}I are the most important radionuclides for this purpose. In order to avoid pharmacological and toxicological effects, the radiolabelled compounds must be often produced with high specific activity. In the first part of this thesis, the work is therefore focused on labelling methods with no carrier added radioiodine. The radioiodinated analogues of two amino acids were chosen as model compounds of research. L-m-tyrosine is potentially useful for the evaluation of dopamine metabolism in Parkinson's disease, while L -{alpha} -methyl tyrosine is a well known indicator of amino acid transport useful for tumor studies.
Citation Formats
Bayoumy, A A M.
Labelling of some organic compounds with radioiodine and technetium-99m.
Egypt: N. p.,
1994.
Web.
Bayoumy, A A M.
Labelling of some organic compounds with radioiodine and technetium-99m.
Egypt.
Bayoumy, A A M.
1994.
"Labelling of some organic compounds with radioiodine and technetium-99m."
Egypt.
@misc{etde_20112262,
title = {Labelling of some organic compounds with radioiodine and technetium-99m}
author = {Bayoumy, A A M}
abstractNote = {Amino acids have received significant attention in the evaluation of serotonergic and dopaminergic functions in the central nervous system. the wide distribution of {gamma}-cameras and SPECT create an increasing need for appropriated labelled radiopharmaceuticals . {sup 99m}Tc and {sup 123}I are the most important radionuclides for this purpose. In order to avoid pharmacological and toxicological effects, the radiolabelled compounds must be often produced with high specific activity. In the first part of this thesis, the work is therefore focused on labelling methods with no carrier added radioiodine. The radioiodinated analogues of two amino acids were chosen as model compounds of research. L-m-tyrosine is potentially useful for the evaluation of dopamine metabolism in Parkinson's disease, while L -{alpha} -methyl tyrosine is a well known indicator of amino acid transport useful for tumor studies.}
place = {Egypt}
year = {1994}
month = {Jul}
}
title = {Labelling of some organic compounds with radioiodine and technetium-99m}
author = {Bayoumy, A A M}
abstractNote = {Amino acids have received significant attention in the evaluation of serotonergic and dopaminergic functions in the central nervous system. the wide distribution of {gamma}-cameras and SPECT create an increasing need for appropriated labelled radiopharmaceuticals . {sup 99m}Tc and {sup 123}I are the most important radionuclides for this purpose. In order to avoid pharmacological and toxicological effects, the radiolabelled compounds must be often produced with high specific activity. In the first part of this thesis, the work is therefore focused on labelling methods with no carrier added radioiodine. The radioiodinated analogues of two amino acids were chosen as model compounds of research. L-m-tyrosine is potentially useful for the evaluation of dopamine metabolism in Parkinson's disease, while L -{alpha} -methyl tyrosine is a well known indicator of amino acid transport useful for tumor studies.}
place = {Egypt}
year = {1994}
month = {Jul}
}