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Biological effect of radiation on human

Abstract

1. Adaptive response when 0.01 Gy was preirradiated before high challenging dose is induced in normal cell types such normal lymphocytes, primary keratinocytes, and L929 fibroblast cells but not in neoplastic cells such as L5178Y lymphoma cells, EL-4 lymphoma cells and 308 papilloma cells. 2. Heat shock protein (HSP) 25 and inducible HSP70 is responsible for the induction of adaptive response and radioresistance - cell cycle regulation, antiapoptotic molecule and PKC activation were involved. 3. Apoptosis was induced at most 5. hrs after irradiation in primary keratinocytes, in v-rasHa transformed keratinocytes, the maximum interval was 16 hrs, and in 308 papilloma cells, the maximum was 48 hrs. 4. PKC response by radiation is correlated with induction of apoptosis. 5. Rapid induction PKCdelta in primary keratinocytes and no response of PKC epsilon may involved in radiation induced apoptosis. 6. The rate of resorption was increased when radiation was given at 2.5 days after gestation. Early death including foetal death were highly expressed when radiation was given at 7.5 days after gestation. There are no difference in incidence of late death including embryonic death. 7. 2 Gy is the most effective dose in radiation induced teratogenesis in mouse model. 8. Growth retardation  More>>
Authors:
Lee, Yun Sil; Cho, Chul Koo; Lee, Su Jae [1] 
  1. and others
Publication Date:
Apr 01, 2000
Product Type:
Technical Report
Report Number:
KCCH/RR-104/99
Reference Number:
EDB-00:115463
Resource Relation:
Other Information: 293 refs, 94 figs, 24 tabs; PBD: Apr 2000
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; ANIMAL CELLS; APOPTOSIS; CARCINOGENESIS; RADIATION DOSES; RADIATIONS; RADIOSENSITIVITY; TERATOGENESIS
OSTI ID:
20101290
Research Organizations:
Korea Atomic Energy Research Institute. Korea Cancer Center Hospital (Korea, Republic of)
Country of Origin:
Korea, Republic of
Language:
Korean
Other Identifying Numbers:
TRN: KR0000182047890
Availability:
Available from INIS in electronic form
Submitting Site:
KRN
Size:
332 pages
Announcement Date:

Citation Formats

Lee, Yun Sil, Cho, Chul Koo, and Lee, Su Jae. Biological effect of radiation on human. Korea, Republic of: N. p., 2000. Web.
Lee, Yun Sil, Cho, Chul Koo, & Lee, Su Jae. Biological effect of radiation on human. Korea, Republic of.
Lee, Yun Sil, Cho, Chul Koo, and Lee, Su Jae. 2000. "Biological effect of radiation on human." Korea, Republic of.
@misc{etde_20101290,
title = {Biological effect of radiation on human}
author = {Lee, Yun Sil, Cho, Chul Koo, and Lee, Su Jae}
abstractNote = {1. Adaptive response when 0.01 Gy was preirradiated before high challenging dose is induced in normal cell types such normal lymphocytes, primary keratinocytes, and L929 fibroblast cells but not in neoplastic cells such as L5178Y lymphoma cells, EL-4 lymphoma cells and 308 papilloma cells. 2. Heat shock protein (HSP) 25 and inducible HSP70 is responsible for the induction of adaptive response and radioresistance - cell cycle regulation, antiapoptotic molecule and PKC activation were involved. 3. Apoptosis was induced at most 5. hrs after irradiation in primary keratinocytes, in v-rasHa transformed keratinocytes, the maximum interval was 16 hrs, and in 308 papilloma cells, the maximum was 48 hrs. 4. PKC response by radiation is correlated with induction of apoptosis. 5. Rapid induction PKCdelta in primary keratinocytes and no response of PKC epsilon may involved in radiation induced apoptosis. 6. The rate of resorption was increased when radiation was given at 2.5 days after gestation. Early death including foetal death were highly expressed when radiation was given at 7.5 days after gestation. There are no difference in incidence of late death including embryonic death. 7. 2 Gy is the most effective dose in radiation induced teratogenesis in mouse model. 8. Growth retardation and small head was present when radiation was given at 5.5, 7.5, 11.5 and 15.5 days after gestation and small head showed high incidence at 11.5 days after gestation. 9. External malformation, internal malformation and skeletal malformation was induced when radiation was given at 7.5 days after gestation. 10. OGG1-mutated cells induced radiosensitive by G2/M cell cycle arrest. 11. Radiation induced G2/M phase cell cycle and correlated with radiosensitivity. 12. PKCalpha induced differentiation. 13. Radiation exposed cells showed carcinogenic effect. 14. Organ specific radiosensitivity was shown and protein expression was involved.}
place = {Korea, Republic of}
year = {2000}
month = {Apr}
}