Abstract
Development of nenroactive materials to improve neuronal defects is one of the most important subjects in Japan that will soon become a aging society. In this project, basic research for neuroactive molecule was performed to develop technology for neuronal regeneration, regulation of synaptic activity and interface between artificial surface and living neurons. A novel neurite promoting factor was discovered and its cDNA was cloned. Mutagenesis in vitro showed that a functional region of this factor located in a polypeptide of less than 50 aminoacids. Using neuronal culture, synapse formation was found to depend on two modes of activities and long-lasting synaptic potentiation was demonstrated to depend on a macromolecules released from pre- or postsynaptic neurons. To regulate nervous activities, photoactivated caged-peptide was developed and confirmed to change in affinity to its receptor. Neurons were cultured on substrates paterned by microlithography. (NEDO)
Citation Formats
None.
FY1995 basic research for neuroactive materials; 1995 nendo shinkei kino zairyo kaihatsu ni kansuru kiban kenkyu.
Japan: N. p.,
1997.
Web.
None.
FY1995 basic research for neuroactive materials; 1995 nendo shinkei kino zairyo kaihatsu ni kansuru kiban kenkyu.
Japan.
None.
1997.
"FY1995 basic research for neuroactive materials; 1995 nendo shinkei kino zairyo kaihatsu ni kansuru kiban kenkyu."
Japan.
@misc{etde_20085415,
title = {FY1995 basic research for neuroactive materials; 1995 nendo shinkei kino zairyo kaihatsu ni kansuru kiban kenkyu}
author = {None}
abstractNote = {Development of nenroactive materials to improve neuronal defects is one of the most important subjects in Japan that will soon become a aging society. In this project, basic research for neuroactive molecule was performed to develop technology for neuronal regeneration, regulation of synaptic activity and interface between artificial surface and living neurons. A novel neurite promoting factor was discovered and its cDNA was cloned. Mutagenesis in vitro showed that a functional region of this factor located in a polypeptide of less than 50 aminoacids. Using neuronal culture, synapse formation was found to depend on two modes of activities and long-lasting synaptic potentiation was demonstrated to depend on a macromolecules released from pre- or postsynaptic neurons. To regulate nervous activities, photoactivated caged-peptide was developed and confirmed to change in affinity to its receptor. Neurons were cultured on substrates paterned by microlithography. (NEDO)}
place = {Japan}
year = {1997}
month = {Mar}
}
title = {FY1995 basic research for neuroactive materials; 1995 nendo shinkei kino zairyo kaihatsu ni kansuru kiban kenkyu}
author = {None}
abstractNote = {Development of nenroactive materials to improve neuronal defects is one of the most important subjects in Japan that will soon become a aging society. In this project, basic research for neuroactive molecule was performed to develop technology for neuronal regeneration, regulation of synaptic activity and interface between artificial surface and living neurons. A novel neurite promoting factor was discovered and its cDNA was cloned. Mutagenesis in vitro showed that a functional region of this factor located in a polypeptide of less than 50 aminoacids. Using neuronal culture, synapse formation was found to depend on two modes of activities and long-lasting synaptic potentiation was demonstrated to depend on a macromolecules released from pre- or postsynaptic neurons. To regulate nervous activities, photoactivated caged-peptide was developed and confirmed to change in affinity to its receptor. Neurons were cultured on substrates paterned by microlithography. (NEDO)}
place = {Japan}
year = {1997}
month = {Mar}
}