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FY1995 basic research for neuroactive materials; 1995 nendo shinkei kino zairyo kaihatsu ni kansuru kiban kenkyu

Abstract

Development of nenroactive materials to improve neuronal defects is one of the most important subjects in Japan that will soon become a aging society. In this project, basic research for neuroactive molecule was performed to develop technology for neuronal regeneration, regulation of synaptic activity and interface between artificial surface and living neurons. A novel neurite promoting factor was discovered and its cDNA was cloned. Mutagenesis in vitro showed that a functional region of this factor located in a polypeptide of less than 50 aminoacids. Using neuronal culture, synapse formation was found to depend on two modes of activities and long-lasting synaptic potentiation was demonstrated to depend on a macromolecules released from pre- or postsynaptic neurons. To regulate nervous activities, photoactivated caged-peptide was developed and confirmed to change in affinity to its receptor. Neurons were cultured on substrates paterned by microlithography. (NEDO)
Authors:
"NONE"
Publication Date:
Mar 01, 1997
Product Type:
Technical Report
Report Number:
JP-NEDO-010010678
Resource Relation:
Other Information: PBD: Mar 1997
Subject:
59 BASIC BIOLOGICAL SCIENCES; NERVOUS SYSTEM; ARTIFICIAL ORGANS; BIOLOGICAL FUNCTIONS; BRAIN; RETROFITTING; MATERIAL SUBSTITUTION; PROTEINS; GENES; CLONING
OSTI ID:
20085415
Research Organizations:
New Energy and Industrial Technology Development Organization, Tokyo (Japan)
Country of Origin:
Japan
Language:
Japanese
Other Identifying Numbers:
TRN: JN9940997
Availability:
Available to ETDE participating countries only(see www.etde.org); commercial reproduction prohibited; OSTI as DE20085415
Submitting Site:
NEDO
Size:
393 pages
Announcement Date:

Citation Formats

FY1995 basic research for neuroactive materials; 1995 nendo shinkei kino zairyo kaihatsu ni kansuru kiban kenkyu. Japan: N. p., 1997. Web.
FY1995 basic research for neuroactive materials; 1995 nendo shinkei kino zairyo kaihatsu ni kansuru kiban kenkyu. Japan.
1997. "FY1995 basic research for neuroactive materials; 1995 nendo shinkei kino zairyo kaihatsu ni kansuru kiban kenkyu." Japan.
@misc{etde_20085415,
title = {FY1995 basic research for neuroactive materials; 1995 nendo shinkei kino zairyo kaihatsu ni kansuru kiban kenkyu}
abstractNote = {Development of nenroactive materials to improve neuronal defects is one of the most important subjects in Japan that will soon become a aging society. In this project, basic research for neuroactive molecule was performed to develop technology for neuronal regeneration, regulation of synaptic activity and interface between artificial surface and living neurons. A novel neurite promoting factor was discovered and its cDNA was cloned. Mutagenesis in vitro showed that a functional region of this factor located in a polypeptide of less than 50 aminoacids. Using neuronal culture, synapse formation was found to depend on two modes of activities and long-lasting synaptic potentiation was demonstrated to depend on a macromolecules released from pre- or postsynaptic neurons. To regulate nervous activities, photoactivated caged-peptide was developed and confirmed to change in affinity to its receptor. Neurons were cultured on substrates paterned by microlithography. (NEDO)}
place = {Japan}
year = {1997}
month = {Mar}
}