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FY1995 new technology of artificial organ materials which can induce host biocompatibility; 1995 nendo jinko zokiyo seitai kino fukatsukagata sozai no kaihatsu gijutsu

Abstract

The aim of this project is to produce a highly biocompatible materials for next generation's artificial organs using the following methods: 1, Micromodification of polymer materials. 2, Biocompatible treatment for biological materials. 3, Application of bioabsorbable materials. 4, Bioactive substance immobilization. and 5, Use of autologous tissue as artificial organ materials. As a synthetic polymer material, microporous polyurethane was used for a small diameter vascular prosthesis. The graft with this technology was successfully implanted in rat abdomical aortic position. The graft of 1.5 mm in internal diameter and 10 cm in length showed excellent patency with nice endothelialisation. As a biological material, microfibers of collagen was used for a sealing substance of vascular prothesis. The microfibers absorbed a large amount of water, which could prevent blood leakage from the graft wall. The graft showed non-thrombogenic property and excellent host cell affinity, resulted in rapid neointima formation. As to autologous tissue, bone marrow was used, since marrow cells can differentiate into any mesenchimal cells with synthesis of growth factors. Marrow cell transplanted vascular prothesis showed rapid capillary ingrowth. These results indicated that the newly designed materials had suitable properties for materials of next generation's artificial organs. (NEDO)
Authors:
"NONE"
Publication Date:
May 01, 1996
Product Type:
Technical Report
Report Number:
JP-NEDO-010010674
Resource Relation:
Other Information: PBD: May 1996
Subject:
59 BASIC BIOLOGICAL SCIENCES; ARTIFICIAL ORGANS; MANUFACTURING; BIOLOGICAL FUNCTIONS; MEDICINE; POLYMERS; MATERIALS WORKING; BIODEGRADATION; POLYURETHANES; COLLAGEN; BLOOD VESSELS
OSTI ID:
20085411
Research Organizations:
New Energy and Industrial Technology Development Organization, Tokyo (Japan)
Country of Origin:
Japan
Language:
Japanese
Other Identifying Numbers:
TRN: JN9940993
Availability:
Available to ETDE participating countries only(see www.etde.org); commercial reproduction prohibited; OSTI as DE20085411
Submitting Site:
NEDO
Size:
147 pages
Announcement Date:

Citation Formats

FY1995 new technology of artificial organ materials which can induce host biocompatibility; 1995 nendo jinko zokiyo seitai kino fukatsukagata sozai no kaihatsu gijutsu. Japan: N. p., 1996. Web.
FY1995 new technology of artificial organ materials which can induce host biocompatibility; 1995 nendo jinko zokiyo seitai kino fukatsukagata sozai no kaihatsu gijutsu. Japan.
1996. "FY1995 new technology of artificial organ materials which can induce host biocompatibility; 1995 nendo jinko zokiyo seitai kino fukatsukagata sozai no kaihatsu gijutsu." Japan.
@misc{etde_20085411,
title = {FY1995 new technology of artificial organ materials which can induce host biocompatibility; 1995 nendo jinko zokiyo seitai kino fukatsukagata sozai no kaihatsu gijutsu}
abstractNote = {The aim of this project is to produce a highly biocompatible materials for next generation's artificial organs using the following methods: 1, Micromodification of polymer materials. 2, Biocompatible treatment for biological materials. 3, Application of bioabsorbable materials. 4, Bioactive substance immobilization. and 5, Use of autologous tissue as artificial organ materials. As a synthetic polymer material, microporous polyurethane was used for a small diameter vascular prosthesis. The graft with this technology was successfully implanted in rat abdomical aortic position. The graft of 1.5 mm in internal diameter and 10 cm in length showed excellent patency with nice endothelialisation. As a biological material, microfibers of collagen was used for a sealing substance of vascular prothesis. The microfibers absorbed a large amount of water, which could prevent blood leakage from the graft wall. The graft showed non-thrombogenic property and excellent host cell affinity, resulted in rapid neointima formation. As to autologous tissue, bone marrow was used, since marrow cells can differentiate into any mesenchimal cells with synthesis of growth factors. Marrow cell transplanted vascular prothesis showed rapid capillary ingrowth. These results indicated that the newly designed materials had suitable properties for materials of next generation's artificial organs. (NEDO)}
place = {Japan}
year = {1996}
month = {May}
}