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Protection of DNA damage by radiation exposure

Abstract

The SOS response of Escherichia coli is positively regulated by RecA. To examine the effects of polyamines on The SOS response of E. Coli, we investigated the expression of recA gene in polyamine-deficient mutant and wild type carrying recA'::lacZ fusion gene. As a result, recA expression by mitomycin C is higher in wild type than that of polyamine-deficient mutant, but recA expression by UV radiation is higher in wild type than of mutant. We also found that exogenous polyamines restored the recA expression in the polyamine-deficient mutant to the wild type level. These results proposed that polyamines play an important role in mechanism of intracellular DNA protection by DNA damaging agents.
Publication Date:
Dec 01, 1998
Product Type:
Technical Report
Report Number:
KAERI/RR-1858/98
Reference Number:
EDB-00:113854
Resource Relation:
Other Information: 26 refs, 5 figs, 1 tab; PBD: Dec 1998
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; DNA DAMAGES; ESCHERICHIA COLI; GENE MUTATIONS; MITOMYCIN; RADIATION INJURIES; RADIATION PROTECTION; ULTRAVIOLET RADIATION
OSTI ID:
20077223
Research Organizations:
Korea Atomic Energy Research Institute (Korea, Republic of)
Country of Origin:
Korea, Republic of
Language:
Korean
Other Identifying Numbers:
TRN: KR0000069034657
Availability:
Available from INIS in electronic form
Submitting Site:
KRN
Size:
30 pages
Announcement Date:

Citation Formats

Lee, Jeong Ho, Kim, In Gyu, Lee, Kang Suk, Kim, Kug Chan, and Oh, Tae Jung. Protection of DNA damage by radiation exposure. Korea, Republic of: N. p., 1998. Web.
Lee, Jeong Ho, Kim, In Gyu, Lee, Kang Suk, Kim, Kug Chan, & Oh, Tae Jung. Protection of DNA damage by radiation exposure. Korea, Republic of.
Lee, Jeong Ho, Kim, In Gyu, Lee, Kang Suk, Kim, Kug Chan, and Oh, Tae Jung. 1998. "Protection of DNA damage by radiation exposure." Korea, Republic of.
@misc{etde_20077223,
title = {Protection of DNA damage by radiation exposure}
author = {Lee, Jeong Ho, Kim, In Gyu, Lee, Kang Suk, Kim, Kug Chan, and Oh, Tae Jung}
abstractNote = {The SOS response of Escherichia coli is positively regulated by RecA. To examine the effects of polyamines on The SOS response of E. Coli, we investigated the expression of recA gene in polyamine-deficient mutant and wild type carrying recA'::lacZ fusion gene. As a result, recA expression by mitomycin C is higher in wild type than that of polyamine-deficient mutant, but recA expression by UV radiation is higher in wild type than of mutant. We also found that exogenous polyamines restored the recA expression in the polyamine-deficient mutant to the wild type level. These results proposed that polyamines play an important role in mechanism of intracellular DNA protection by DNA damaging agents.}
place = {Korea, Republic of}
year = {1998}
month = {Dec}
}