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Total body fat, pro-inflammatory cytokines and insulin resistance in Indian subjects

Abstract

There is a growing epidemic of insulin resistance syndrome (IRS) in Indians. We postulate that increased susceptibility of the urban Indians to insulin resistance is a result of a tendency to increased fat deposition from the time of intrauterine life (thrifty phenotype), exaggerated in the urban environment by a positive energy balance. The pro-inflammatory cytokines secreted by the inflammatory cells as well by the adipose tissue could aggravate insulin resistance and endothelial damage and therefore, increase the susceptibility to type 2 diabetes and coronary heart disease (CHD) independent of the previously proposed glucose fatty acid cycle mechanism. In a preliminary study, we propose to make detailed measurements of the proposed mechanisms in a selected population from 3 geographical locations in and near the city of Pune, India and also validate simple 'epidemiologic' measurements of body composition with 'reference' measurements. One hundred men (30 to 50y) each from the three geographical locations (rural, urban slum-dwellers and urban middle class in Pune) will be studied for: (i) Body composition: Anthropometric and bioimpedance measurement of total body fat (to be calibrated against deuterated water in 30 subjects from each location), and muscle mass by anthropometry and urinary creatinine excretion; (ii) Body fat distribution  More>>
Authors:
Yajnik, C S; [1]  Yudkin, J S; [2]  Shetty, P S; [3]  Kurpad, A [4] 
  1. Diabetes Unit, KEM Hospital Research Centre, Pune (India)
  2. Whittington Hospital, University College of London, London (United Kingdom)
  3. London School of Hygiene and Tropical Medicine, London (United Kingdom)
  4. St. John's Medical College, Bangalore (India)
Publication Date:
Jul 01, 1999
Product Type:
Conference
Report Number:
NAHRES-47
Reference Number:
EDB-00:112859
Resource Relation:
Conference: 1. research co-ordination meeting on co-ordinated research project on application of nuclear techniques in the prevention of degenerative diseases (obesity and non-insulin dependent diabetes) in ageing, Vienna (Austria), 3-7 May 1999; Other Information: 24 refs, 1 tab; PBD: 1999; Related Information: In: Co-ordinated research project on application of nuclear techniques in the prevention of degenerative diseases (obesity and non-insulin dependent diabetes) in ageing, 95 pages.
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BIOLOGICAL MARKERS; BODY COMPOSITION; DIABETES MELLITUS; ENERGY BALANCE; EPIDEMIOLOGY; FATS; INSULIN; METABOLIC DISEASES; NUTRITION
OSTI ID:
20067524
Research Organizations:
International Atomic Energy Agency, Section of Nutritional and Health-Related Environmental Studies, Vienna (Austria)
Country of Origin:
IAEA
Language:
English
Other Identifying Numbers:
TRN: XA0054846030003
Availability:
Available from INIS in electronic form
Submitting Site:
INIS
Size:
page(s) 38-43
Announcement Date:

Citation Formats

Yajnik, C S, Yudkin, J S, Shetty, P S, and Kurpad, A. Total body fat, pro-inflammatory cytokines and insulin resistance in Indian subjects. IAEA: N. p., 1999. Web.
Yajnik, C S, Yudkin, J S, Shetty, P S, & Kurpad, A. Total body fat, pro-inflammatory cytokines and insulin resistance in Indian subjects. IAEA.
Yajnik, C S, Yudkin, J S, Shetty, P S, and Kurpad, A. 1999. "Total body fat, pro-inflammatory cytokines and insulin resistance in Indian subjects." IAEA.
@misc{etde_20067524,
title = {Total body fat, pro-inflammatory cytokines and insulin resistance in Indian subjects}
author = {Yajnik, C S, Yudkin, J S, Shetty, P S, and Kurpad, A}
abstractNote = {There is a growing epidemic of insulin resistance syndrome (IRS) in Indians. We postulate that increased susceptibility of the urban Indians to insulin resistance is a result of a tendency to increased fat deposition from the time of intrauterine life (thrifty phenotype), exaggerated in the urban environment by a positive energy balance. The pro-inflammatory cytokines secreted by the inflammatory cells as well by the adipose tissue could aggravate insulin resistance and endothelial damage and therefore, increase the susceptibility to type 2 diabetes and coronary heart disease (CHD) independent of the previously proposed glucose fatty acid cycle mechanism. In a preliminary study, we propose to make detailed measurements of the proposed mechanisms in a selected population from 3 geographical locations in and near the city of Pune, India and also validate simple 'epidemiologic' measurements of body composition with 'reference' measurements. One hundred men (30 to 50y) each from the three geographical locations (rural, urban slum-dwellers and urban middle class in Pune) will be studied for: (i) Body composition: Anthropometric and bioimpedance measurement of total body fat (to be calibrated against deuterated water in 30 subjects from each location), and muscle mass by anthropometry and urinary creatinine excretion; (ii) Body fat distribution by subscapular- triceps ratio, waist-hip ratio; (iii) Metabolic: Glucose tolerance and insulin resistance variables (insulin, lipids, NEFA) and leptin; (iv) Endothelial markers: e-Selectin and von Willebrand Factor (vWF); (v) Inflammatory markers and pro-inflammatory cytokines: C-reactive protein (CRP), Interleukin-6 (IL-6) and tumour necrosis factor (TNF- {alpha}); (vi) Energy Balance: Assessment of nutritional intake (calories, carbohydrates, proteins and fats, n3 and n6 fatty acids) and physical activity by a questionnaire. Insulin resistance variables, endothelial markers, cytokines and obesity parameters will be compared in the 3 groups. Energy intake and physical activity will be related to obesity parameters and n3 and n6 fatty acid intake will be related to inflammatory markers. Multivariate analysis will be used to explore the independent contributions of levels of circulating cytokines and of obesity to insulin resistance syndrome variables and endothelial markers, controlling for place of residence. (author)}
place = {IAEA}
year = {1999}
month = {Jul}
}