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The radioprotective effects of Noni (Morinda citrifolia L.) juice on the bone marrow of irradiated Mus musculus L

Abstract

The radioprotective effects of Noni juice on the bone marrow of irradiated Mus musculus L. (7-week old IRC strain) was studied using the micronucleus test. Five mice were used for each of the six groups; negative and positive control, 25%, 50%, 75%, 100% treatment. Both negative and positive control groups were not treated with Noni juice. However, the negative control was not irradiated. Four different concentrations, a mixture of distilled water and commercial Noni juice, were administered via oral gavage to mice in their specific groups during the 15-day feeding schedule. A day (24H) after the last treatment, the mice were irradiated (6 Gy of gamma radiation). Two days (48H) after irradiation, the mice were sacrifice and the femur were extracted. The bone marrow cells were collected and slides were prepared. One thousand polychromatic erythrocytes (PCE) were screened for the presence of micronucleus per mouse. The mean frequency of micronucleated PCE were as follows: negative control, 15; positive control, 45; 25% treatment, 21; 50% treatment, 18; 75% treatment, 11; 100% treatment, 7. The Kruskal-Wallis test showed that the groups' responses varied ({alpha}=0.05). Multiple comparison showed that there were significant differences between: (1) 25% and 100% treatment group; (2) positive control  More>>
Publication Date:
Mar 01, 2000
Product Type:
Thesis/Dissertation
Report Number:
INIS-PH-006
Reference Number:
EDB-00:112644
Resource Relation:
Other Information: TH: B.S. Biology; 31 refs, 21 figs, 8 tabs; PBD: Mar 2000
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; BONE MARROW; BONE MARROW CELLS; EXPERIMENTAL DATA; FRUIT TREES; GAMMA RADIATION; IRRADIATION; MICE; NUMERICAL DATA; PLANTS; RADIOPROTECTIVE SUBSTANCES
OSTI ID:
20067303
Research Organizations:
University of the Philippines, Manila (Philippines) College of Arts and Sciences, Dept. of Biology
Country of Origin:
Philippines
Language:
English
Other Identifying Numbers:
TRN: PH0000003029640
Availability:
Available from INIS in electronic form; Also available from PNRI library
Submitting Site:
INIS
Size:
59 pages
Announcement Date:

Citation Formats

Boquiren, Ryan Albert Leonard N., and Te Tan, Alvin E. The radioprotective effects of Noni (Morinda citrifolia L.) juice on the bone marrow of irradiated Mus musculus L. Philippines: N. p., 2000. Web.
Boquiren, Ryan Albert Leonard N., & Te Tan, Alvin E. The radioprotective effects of Noni (Morinda citrifolia L.) juice on the bone marrow of irradiated Mus musculus L. Philippines.
Boquiren, Ryan Albert Leonard N., and Te Tan, Alvin E. 2000. "The radioprotective effects of Noni (Morinda citrifolia L.) juice on the bone marrow of irradiated Mus musculus L." Philippines.
@misc{etde_20067303,
title = {The radioprotective effects of Noni (Morinda citrifolia L.) juice on the bone marrow of irradiated Mus musculus L}
author = {Boquiren, Ryan Albert Leonard N., and Te Tan, Alvin E}
abstractNote = {The radioprotective effects of Noni juice on the bone marrow of irradiated Mus musculus L. (7-week old IRC strain) was studied using the micronucleus test. Five mice were used for each of the six groups; negative and positive control, 25%, 50%, 75%, 100% treatment. Both negative and positive control groups were not treated with Noni juice. However, the negative control was not irradiated. Four different concentrations, a mixture of distilled water and commercial Noni juice, were administered via oral gavage to mice in their specific groups during the 15-day feeding schedule. A day (24H) after the last treatment, the mice were irradiated (6 Gy of gamma radiation). Two days (48H) after irradiation, the mice were sacrifice and the femur were extracted. The bone marrow cells were collected and slides were prepared. One thousand polychromatic erythrocytes (PCE) were screened for the presence of micronucleus per mouse. The mean frequency of micronucleated PCE were as follows: negative control, 15; positive control, 45; 25% treatment, 21; 50% treatment, 18; 75% treatment, 11; 100% treatment, 7. The Kruskal-Wallis test showed that the groups' responses varied ({alpha}=0.05). Multiple comparison showed that there were significant differences between: (1) 25% and 100% treatment group; (2) positive control group and 75% treatment group; (3) positive control group and 100% treatment group, thus indicating that Noni juice is effective in inhibiting micronucleus formation at high concentrations. The result also showed that radioprotective potential of Noni juice follows a dose-dependent pattern. (Author)}
place = {Philippines}
year = {2000}
month = {Mar}
}