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Pharmacokinetics of labelled compounds with technetium-99m and samarium-153; Farmacocinetica de compuestos marcados con tecnecio-99m y samario-153

Abstract

The purpose of this investigation was to establish the different pharmacokinetics parameters of the main radiopharmaceuticals labeled with technetium-99m and samarium-153. These parameters could be subsequently used as reference to compare other products with the same use. Mathematical models and a computerized pharmacokinetic program were used to this purpose. A biodistribution study in quadruplicate and/or quintuplicate was conducted for each radiopharmaceutical, data was was obtained in injection dose percentages. The biodistribution study involved the injection of a predetermined dose of the radiopharmaceutical into animals (rats or mice), which were subsequently put away at different time intervals, removing the relevant organs. Activity in each organ was read by means of a well-type NaI scintillation counter, data obtained in activity counts was transformed into injection dose percentages. Based on these percentages, the mathematical model was constructed and the pharmacokinetic parameters were obtained using the computerized program Expo 2 v. 1, which is written in C language and works in windows. Analyzing the results obtained, we can conclude that the use of the Expo 2 v. 1 program for a bi compartmental analysis allowed us to obtain reliable pharmacokinetic parameters which describe what happens in the organism when the radiopharmaceutical passes from the  More>>
Publication Date:
Jul 01, 1997
Product Type:
Thesis/Dissertation
Report Number:
INIS-PE-11
Reference Number:
EDB-00:107215
Resource Relation:
Other Information: TH: Thesis (Pharmaceutical Chemist); 65 refs., 3 figs., 37 ills; PBD: 1997
Subject:
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY; IN VIVO; ISOTOPE PRODUCTION; LABELLED COMPOUNDS; NUCLEAR MEDICINE; RADIOISOTOPES; RADIONUCLIDE KINETICS; RADIOPHARMACEUTICALS; SAMARIUM 153; TECHNETIUM 99
OSTI ID:
20048001
Research Organizations:
Universidad Nacional Mayor de San Marcos, Facultad de Farmacia y Bioquimica, Lima (Peru)
Country of Origin:
Peru
Language:
Spanish
Other Identifying Numbers:
TRN: PE0000002011553
Availability:
Available from INIS in electronic form
Submitting Site:
INIS
Size:
106 pages
Announcement Date:
Dec 18, 2000

Citation Formats

Borda O, L B, and Torres L, M N. Pharmacokinetics of labelled compounds with technetium-99m and samarium-153; Farmacocinetica de compuestos marcados con tecnecio-99m y samario-153. Peru: N. p., 1997. Web.
Borda O, L B, & Torres L, M N. Pharmacokinetics of labelled compounds with technetium-99m and samarium-153; Farmacocinetica de compuestos marcados con tecnecio-99m y samario-153. Peru.
Borda O, L B, and Torres L, M N. 1997. "Pharmacokinetics of labelled compounds with technetium-99m and samarium-153; Farmacocinetica de compuestos marcados con tecnecio-99m y samario-153." Peru.
@misc{etde_20048001,
title = {Pharmacokinetics of labelled compounds with technetium-99m and samarium-153; Farmacocinetica de compuestos marcados con tecnecio-99m y samario-153}
author = {Borda O, L B, and Torres L, M N}
abstractNote = {The purpose of this investigation was to establish the different pharmacokinetics parameters of the main radiopharmaceuticals labeled with technetium-99m and samarium-153. These parameters could be subsequently used as reference to compare other products with the same use. Mathematical models and a computerized pharmacokinetic program were used to this purpose. A biodistribution study in quadruplicate and/or quintuplicate was conducted for each radiopharmaceutical, data was was obtained in injection dose percentages. The biodistribution study involved the injection of a predetermined dose of the radiopharmaceutical into animals (rats or mice), which were subsequently put away at different time intervals, removing the relevant organs. Activity in each organ was read by means of a well-type NaI scintillation counter, data obtained in activity counts was transformed into injection dose percentages. Based on these percentages, the mathematical model was constructed and the pharmacokinetic parameters were obtained using the computerized program Expo 2 v. 1, which is written in C language and works in windows. Analyzing the results obtained, we can conclude that the use of the Expo 2 v. 1 program for a bi compartmental analysis allowed us to obtain reliable pharmacokinetic parameters which describe what happens in the organism when the radiopharmaceutical passes from the central compartment to the peripheral one and vice versa.}
place = {Peru}
year = {1997}
month = {Jul}
}