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On the issue of higher human sensitivity to carcinogenic substances in early childhood; Zur Frage einer hoeheren Empfindlichkeit von Kindern gegenueber krebserzeugenden Stoffen

Abstract

Age-dependent carcinogenesis in humans has been proven with high probability for a number of substances investigated within one or several model systems. Sometimes, very high tumor incidence after short exposure time was observed. Extreme differences were found in some models. (A) Vinyl chloride, Maltoni et al.,1981: 6000 ppm, hepatic angiosarcoma incidence: - Exposure for 4 weeks, from day 1: 40.5 %, - exposure for 4 weeks, from week 13: 0%, - exposure for 52 weeks, from week 13: 22%. Hepatoma incidence: - Exposure for 4 weeks, from day 1: 47.6%, exposure for 4 weeks, from week 13: 0%, exposure for 52 weeks, from week 13: 1.7%. (B) Diethyl nitrosamine, Dyroff et al., 1986: (DEN + phenobarbital), hepatic carcinoma after exposure of rats for 6 weeks: - as from 4 weeks of age: 100% incidence, - as from 8 weeks of age: 0% incidence. (C) Benzopyrene, Vesselinovitch et al., 1975: Hepatic tumor incidence after single, parenteral administration to rats: - at day 1: males: 81%, females: 18%, - at day 42: males: 9%, females: 0%. As is shown by the study on vinyl chloride by Maltoni et al., the same exposure concentration may lead to higher tumor incidence in young animals  More>>
Authors:
Schneider, K [1] 
  1. comp.
Publication Date:
Sep 01, 1998
Product Type:
Technical Report
Report Number:
UBA-FB-99-029
Reference Number:
EDB-00:096490
Resource Relation:
Other Information: PBD: Sep 1998
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; CARCINOGENESIS; AGE DEPENDENCE; CHILDREN; SENSITIVITY; POLLUTANTS; VINYL CHLORIDE; BENZOPYRENE; NITROSAMINES; GENETIC EFFECTS; TOXICITY; ANIMALS; NEOPLASMS; BIOLOGICAL MODELS
Sponsoring Organizations:
Umweltbundesamt, Berlin (Germany); Bundesministerium fuer Umwelt, Naturschutz und Reaktorsicherheit, Bonn (Germany)
OSTI ID:
20010934
Research Organizations:
FoBiG Forschungs- und Beratungsinstitut Gefahrstoffe GmbH, Freiburg im Breisgau (Germany)
Country of Origin:
Germany
Language:
German
Other Identifying Numbers:
Other: Contract UBA 29574124; TRN: DE99GD346
Availability:
Available to ETDE participating countries only(see www.etde.org); commercial reproduction prohibited; OSTI as DE20010934
Submitting Site:
DE
Size:
67 pages
Announcement Date:
Nov 15, 2000

Citation Formats

Schneider, K. On the issue of higher human sensitivity to carcinogenic substances in early childhood; Zur Frage einer hoeheren Empfindlichkeit von Kindern gegenueber krebserzeugenden Stoffen. Germany: N. p., 1998. Web.
Schneider, K. On the issue of higher human sensitivity to carcinogenic substances in early childhood; Zur Frage einer hoeheren Empfindlichkeit von Kindern gegenueber krebserzeugenden Stoffen. Germany.
Schneider, K. 1998. "On the issue of higher human sensitivity to carcinogenic substances in early childhood; Zur Frage einer hoeheren Empfindlichkeit von Kindern gegenueber krebserzeugenden Stoffen." Germany.
@misc{etde_20010934,
title = {On the issue of higher human sensitivity to carcinogenic substances in early childhood; Zur Frage einer hoeheren Empfindlichkeit von Kindern gegenueber krebserzeugenden Stoffen}
author = {Schneider, K}
abstractNote = {Age-dependent carcinogenesis in humans has been proven with high probability for a number of substances investigated within one or several model systems. Sometimes, very high tumor incidence after short exposure time was observed. Extreme differences were found in some models. (A) Vinyl chloride, Maltoni et al.,1981: 6000 ppm, hepatic angiosarcoma incidence: - Exposure for 4 weeks, from day 1: 40.5 %, - exposure for 4 weeks, from week 13: 0%, - exposure for 52 weeks, from week 13: 22%. Hepatoma incidence: - Exposure for 4 weeks, from day 1: 47.6%, exposure for 4 weeks, from week 13: 0%, exposure for 52 weeks, from week 13: 1.7%. (B) Diethyl nitrosamine, Dyroff et al., 1986: (DEN + phenobarbital), hepatic carcinoma after exposure of rats for 6 weeks: - as from 4 weeks of age: 100% incidence, - as from 8 weeks of age: 0% incidence. (C) Benzopyrene, Vesselinovitch et al., 1975: Hepatic tumor incidence after single, parenteral administration to rats: - at day 1: males: 81%, females: 18%, - at day 42: males: 9%, females: 0%. As is shown by the study on vinyl chloride by Maltoni et al., the same exposure concentration may lead to higher tumor incidence in young animals after short exposure times than it does in long-term experiments with adult animals. Genetic toxicity was detected for all substances, except for saccharin. So it can be assumed that the mechanism of carcinogenesis has an essential influence on the age-dependence. This conclusion agrees well with mechanistic approaches. (orig./CB) [German] Fuer eine Reihe von Schadstoffen ist eine Altersabhaengigkeit der Kanzerogenese mit hoher Wahrscheinlichkeit in einem oder mehreren Modellsystemen gezeigt worden. Dabei wurden zum Teil bereits nach kurzer Expositionszeit sehr hohe Tumorausbeuten erzielt. Extreme Unterschiede wurden in folgenden Modellen beobachtet. (A) Vinylchlorid, Maltoni et al., 1981: 6000 ppm, Inzidenz Leberangiosarkome: - Exposition ueber 4 Wochen ab Tag 1: 40,5%, - Exposition ueber 4 Wochen ab 13. Woche: 0%, - Exposition ueber 52 Wochen ab 13. Woche: 22%. Inzidenz Hepatome: - Exposition ueber 4 Wochen ab Tag 1: 47,6%, - Exposition ueber 4 Wochen ab 13. Woche: 0%, - Exposition ueber 52 Wochen ab 13. Woche: 1,7%. (B) Diethylnitrosamin, Dyroff et al., 1986: (DEN + Phenobarbital), Hepatokarzinomen nach Exposition von Ratten ueber 6 Wochen: - beginnend im Alter von 4 Wochen: 100% Inzidenz, - beginnend im Alter von 8 Wochen: 0% Inzidenz. (C) Benz(a)pyren, Vesselinovitch et al., 1975: Lebertumoren nach einmaliger parenteraler Applikation an Ratten: - im Alter von 1 Tag: maennl.: 81% weibl.: 18%, - im Alter von 42 Tagen: maennl.: 9%, weibl.: 0%. Wie die Untersuchung von Maltoni et al. (1981) zu Vinylchlorid zeigt, kann bei gleicher Expositionskonzentration eine Exposition junger Tiere ueber einen kurzen Zeitraum zu einer hoeheren Tumorinzidenz fuehren als das Langzeitexperiment mit erwachsenen Tieren. Fuer alle Stoffe mit Ausnahme von Saccharin wurde eine gentoxische Wirkung nachgewiesen. Dies laesst vermuten, dass der Mechanismus der Kanzerogenese wesentlichen Einfluss auf die Altersabhaengigkeit hat. Dies steht in Einklang mit den mechanistischen Ueberlegungen. (orig.)}
place = {Germany}
year = {1998}
month = {Sep}
}