Abstract
Adult rats were treated a single, whole body exposure to a dose of 0.1, 0.5, 1.0, 2.0, 3.0 Gy. The animals were sacrificed 6, 24, 48, 72, 96 hours following exposure. The amount of serum acute phase proteins(haptoglobin, ceruloplasmin, C-reactive protein, alpha-1 antitrypsin, alpha-1 acid glycoprotein, transferrin) were measured by competitive ELISA. In the 0.1 Gy irradiated rats, serum haptoglobin, C-reactive protein and alpha-1 antitrypsin were 400% higher and serum transferrin was 50% lower as compared to controls, 96 hours after irradiation. Ceruloplasmin increased by 400%, 24 hours after irradiation, but 96 hours after irradiation, the concentration of this protein in rat returned to normal level. On the other hand, no changes were observed in the case of alpha-1 acid glycoprotein. In the group of the 3.0 Gy irradiated rats, transferrin increased by 200%, 96 hours after irradiation. These biochemical responses to radiation did not show dose-dependent relation, but the sensitivity of the indicators was high enough to detect absorbed dose of 0.1 Gy. The above results can be applied to the measurements of acute phase reactants in human serum for the assessment of exposure doses in radiation workers and patients under radiation therapy. 39 figs, 72 refs. (Author).
Lee, Kang Suk;
Kim, Kook Chan;
Kim, In Kyoo;
Kim, Jin Kyoo;
Jung, Chun Kee;
Park, Hyo Kook;
Kim, Sang Bok;
Yung, Park Sun
[1]
- Korea Atomic Energy Research Institute, Taejon (Korea, Republic of)
Citation Formats
Lee, Kang Suk, Kim, Kook Chan, Kim, In Kyoo, Kim, Jin Kyoo, Jung, Chun Kee, Park, Hyo Kook, Kim, Sang Bok, and Yung, Park Sun.
A study on the radiation and environment safety -Development of technology for biological dosimetry-.
Korea, Republic of: N. p.,
1995.
Web.
Lee, Kang Suk, Kim, Kook Chan, Kim, In Kyoo, Kim, Jin Kyoo, Jung, Chun Kee, Park, Hyo Kook, Kim, Sang Bok, & Yung, Park Sun.
A study on the radiation and environment safety -Development of technology for biological dosimetry-.
Korea, Republic of.
Lee, Kang Suk, Kim, Kook Chan, Kim, In Kyoo, Kim, Jin Kyoo, Jung, Chun Kee, Park, Hyo Kook, Kim, Sang Bok, and Yung, Park Sun.
1995.
"A study on the radiation and environment safety -Development of technology for biological dosimetry-."
Korea, Republic of.
@misc{etde_187134,
title = {A study on the radiation and environment safety -Development of technology for biological dosimetry-}
author = {Lee, Kang Suk, Kim, Kook Chan, Kim, In Kyoo, Kim, Jin Kyoo, Jung, Chun Kee, Park, Hyo Kook, Kim, Sang Bok, and Yung, Park Sun}
abstractNote = {Adult rats were treated a single, whole body exposure to a dose of 0.1, 0.5, 1.0, 2.0, 3.0 Gy. The animals were sacrificed 6, 24, 48, 72, 96 hours following exposure. The amount of serum acute phase proteins(haptoglobin, ceruloplasmin, C-reactive protein, alpha-1 antitrypsin, alpha-1 acid glycoprotein, transferrin) were measured by competitive ELISA. In the 0.1 Gy irradiated rats, serum haptoglobin, C-reactive protein and alpha-1 antitrypsin were 400% higher and serum transferrin was 50% lower as compared to controls, 96 hours after irradiation. Ceruloplasmin increased by 400%, 24 hours after irradiation, but 96 hours after irradiation, the concentration of this protein in rat returned to normal level. On the other hand, no changes were observed in the case of alpha-1 acid glycoprotein. In the group of the 3.0 Gy irradiated rats, transferrin increased by 200%, 96 hours after irradiation. These biochemical responses to radiation did not show dose-dependent relation, but the sensitivity of the indicators was high enough to detect absorbed dose of 0.1 Gy. The above results can be applied to the measurements of acute phase reactants in human serum for the assessment of exposure doses in radiation workers and patients under radiation therapy. 39 figs, 72 refs. (Author).}
place = {Korea, Republic of}
year = {1995}
month = {Jul}
}
title = {A study on the radiation and environment safety -Development of technology for biological dosimetry-}
author = {Lee, Kang Suk, Kim, Kook Chan, Kim, In Kyoo, Kim, Jin Kyoo, Jung, Chun Kee, Park, Hyo Kook, Kim, Sang Bok, and Yung, Park Sun}
abstractNote = {Adult rats were treated a single, whole body exposure to a dose of 0.1, 0.5, 1.0, 2.0, 3.0 Gy. The animals were sacrificed 6, 24, 48, 72, 96 hours following exposure. The amount of serum acute phase proteins(haptoglobin, ceruloplasmin, C-reactive protein, alpha-1 antitrypsin, alpha-1 acid glycoprotein, transferrin) were measured by competitive ELISA. In the 0.1 Gy irradiated rats, serum haptoglobin, C-reactive protein and alpha-1 antitrypsin were 400% higher and serum transferrin was 50% lower as compared to controls, 96 hours after irradiation. Ceruloplasmin increased by 400%, 24 hours after irradiation, but 96 hours after irradiation, the concentration of this protein in rat returned to normal level. On the other hand, no changes were observed in the case of alpha-1 acid glycoprotein. In the group of the 3.0 Gy irradiated rats, transferrin increased by 200%, 96 hours after irradiation. These biochemical responses to radiation did not show dose-dependent relation, but the sensitivity of the indicators was high enough to detect absorbed dose of 0.1 Gy. The above results can be applied to the measurements of acute phase reactants in human serum for the assessment of exposure doses in radiation workers and patients under radiation therapy. 39 figs, 72 refs. (Author).}
place = {Korea, Republic of}
year = {1995}
month = {Jul}
}