Abstract
Mercury, a known neurotoxin, has been implicated in etiology and pathogenesis of such disease states as Alzheimer`s and Parkinson`s diseases. There is concern that the exposure to mercury vapor released from dental amalgam restorations is a potential health hazard. Measurement of mercury concentrations in blood or urine may be useful in diagnosis of mercury poisoning and in assessing the extent exposure. This study describes the optimization of pre-neutron activation analysis procedures such as sampling, selection of irradiation and counting vials and acid digestion in order to minimize mercury loss via volatilization and/or permeation through containers. Therefore, the determination of mercury can be complicated by these potential losses. In the optimized procedure 20mL of urine was spiked with three different concentrations of mercury, digested with concentrated nitric acid, and placed in polypropylene vials for irradiation and counting. Analysis was performed by subtracting the Se-75 photopeak contribution to the 279 keV Hg-203 photopeak and applying the method of standard additions. Urinary mercury concentrations in normal human subjects were determined to be of the order of 10ng/mL. (author). 22 refs., 1 fig., 5 tabs.
Blotcky, A J;
Claassen, J P;
[1]
Fung, Y K;
[2]
Meade, A G;
Rack, E P
[3]
- Nebraska Univ., Omaha, NE (United States). Medical Center
- Nebraska Univ., Lincoln, NE (United States). Dept. of Chemistry
- Nebraska Univ., Lincoln, NE (United States)
Citation Formats
Blotcky, A J, Claassen, J P, Fung, Y K, Meade, A G, and Rack, E P.
Optimization of procedures for mercury-203 instrumental neutron activation analysis in human urine.
Hungary: N. p.,
1995.
Web.
doi:10.1007/BF02036479.
Blotcky, A J, Claassen, J P, Fung, Y K, Meade, A G, & Rack, E P.
Optimization of procedures for mercury-203 instrumental neutron activation analysis in human urine.
Hungary.
https://doi.org/10.1007/BF02036479
Blotcky, A J, Claassen, J P, Fung, Y K, Meade, A G, and Rack, E P.
1995.
"Optimization of procedures for mercury-203 instrumental neutron activation analysis in human urine."
Hungary.
https://doi.org/10.1007/BF02036479.
@misc{etde_183991,
title = {Optimization of procedures for mercury-203 instrumental neutron activation analysis in human urine}
author = {Blotcky, A J, Claassen, J P, Fung, Y K, Meade, A G, and Rack, E P}
abstractNote = {Mercury, a known neurotoxin, has been implicated in etiology and pathogenesis of such disease states as Alzheimer`s and Parkinson`s diseases. There is concern that the exposure to mercury vapor released from dental amalgam restorations is a potential health hazard. Measurement of mercury concentrations in blood or urine may be useful in diagnosis of mercury poisoning and in assessing the extent exposure. This study describes the optimization of pre-neutron activation analysis procedures such as sampling, selection of irradiation and counting vials and acid digestion in order to minimize mercury loss via volatilization and/or permeation through containers. Therefore, the determination of mercury can be complicated by these potential losses. In the optimized procedure 20mL of urine was spiked with three different concentrations of mercury, digested with concentrated nitric acid, and placed in polypropylene vials for irradiation and counting. Analysis was performed by subtracting the Se-75 photopeak contribution to the 279 keV Hg-203 photopeak and applying the method of standard additions. Urinary mercury concentrations in normal human subjects were determined to be of the order of 10ng/mL. (author). 22 refs., 1 fig., 5 tabs.}
doi = {10.1007/BF02036479}
journal = []
issue = {1}
volume = {195}
journal type = {AC}
place = {Hungary}
year = {1995}
month = {Aug}
}
title = {Optimization of procedures for mercury-203 instrumental neutron activation analysis in human urine}
author = {Blotcky, A J, Claassen, J P, Fung, Y K, Meade, A G, and Rack, E P}
abstractNote = {Mercury, a known neurotoxin, has been implicated in etiology and pathogenesis of such disease states as Alzheimer`s and Parkinson`s diseases. There is concern that the exposure to mercury vapor released from dental amalgam restorations is a potential health hazard. Measurement of mercury concentrations in blood or urine may be useful in diagnosis of mercury poisoning and in assessing the extent exposure. This study describes the optimization of pre-neutron activation analysis procedures such as sampling, selection of irradiation and counting vials and acid digestion in order to minimize mercury loss via volatilization and/or permeation through containers. Therefore, the determination of mercury can be complicated by these potential losses. In the optimized procedure 20mL of urine was spiked with three different concentrations of mercury, digested with concentrated nitric acid, and placed in polypropylene vials for irradiation and counting. Analysis was performed by subtracting the Se-75 photopeak contribution to the 279 keV Hg-203 photopeak and applying the method of standard additions. Urinary mercury concentrations in normal human subjects were determined to be of the order of 10ng/mL. (author). 22 refs., 1 fig., 5 tabs.}
doi = {10.1007/BF02036479}
journal = []
issue = {1}
volume = {195}
journal type = {AC}
place = {Hungary}
year = {1995}
month = {Aug}
}