Abstract
In the present study, investigations have been undertaken on the effect of whole body gamma irradiation of swiss albino mice, at the lethal dose level of 8 Gy, on the morphological appearance, mortality rate, immune system and histopathological pattern of spleen. Attempts have been made to screen the prophylactic and/or the curative effect of the sulfhydryl-bearing chemical compound; Mpg (Thiols) and/or the product; olive oil; against the radiation induced disorders on the above mentioned parameters. In the course of investigations carried out on the immune system, emphasis has been given to rosette forming cells from spleen lymphocytes. Whole irradiation demonstrated symptoms of radiation sickness. Morphological observations showed shivering, epilation, diarrhea, retarded physical activity and potentiated mortality rate. Response of immune system has been manifested by drastic retardation in rosette forming cells from spleen lymphocytes. Histopathological examinations showed significant structural changes in spleen tissues. Application of Mpg or olive oil, individually or successively, showed a significant radioprotective capacity for Mpg and a significant radio curative efficacy of olive oil. Combined effect of both treatments resulted in better control of the radiation induced disorders. Possible application on human subjects still awaits further investigations. 5 figs., 2 tabs.
El-Bialy, M G;
El-Kady, M H;
[1]
El-Aaser, A A;
[2]
Mahmoud, K E
[3]
- National Centre for Radiation Research and Technology, Atomic Energy Authority, Cairo (Egypt)
- National Gancer Institute, Cairo University (Egypt)
- Faculty of Veterinary Medicine, Zagazig Univ. (Egypt)
Citation Formats
El-Bialy, M G, El-Kady, M H, El-Aaser, A A, and Mahmoud, K E.
Protective role of Mpg and Olive Oil against hazard of whole body gamma irradiation 3. immune system, survival rate and spleen histopathology in albino mice..
Egypt: N. p.,
1986.
Web.
El-Bialy, M G, El-Kady, M H, El-Aaser, A A, & Mahmoud, K E.
Protective role of Mpg and Olive Oil against hazard of whole body gamma irradiation 3. immune system, survival rate and spleen histopathology in albino mice..
Egypt.
El-Bialy, M G, El-Kady, M H, El-Aaser, A A, and Mahmoud, K E.
1986.
"Protective role of Mpg and Olive Oil against hazard of whole body gamma irradiation 3. immune system, survival rate and spleen histopathology in albino mice."
Egypt.
@misc{etde_172944,
title = {Protective role of Mpg and Olive Oil against hazard of whole body gamma irradiation 3. immune system, survival rate and spleen histopathology in albino mice.}
author = {El-Bialy, M G, El-Kady, M H, El-Aaser, A A, and Mahmoud, K E}
abstractNote = {In the present study, investigations have been undertaken on the effect of whole body gamma irradiation of swiss albino mice, at the lethal dose level of 8 Gy, on the morphological appearance, mortality rate, immune system and histopathological pattern of spleen. Attempts have been made to screen the prophylactic and/or the curative effect of the sulfhydryl-bearing chemical compound; Mpg (Thiols) and/or the product; olive oil; against the radiation induced disorders on the above mentioned parameters. In the course of investigations carried out on the immune system, emphasis has been given to rosette forming cells from spleen lymphocytes. Whole irradiation demonstrated symptoms of radiation sickness. Morphological observations showed shivering, epilation, diarrhea, retarded physical activity and potentiated mortality rate. Response of immune system has been manifested by drastic retardation in rosette forming cells from spleen lymphocytes. Histopathological examinations showed significant structural changes in spleen tissues. Application of Mpg or olive oil, individually or successively, showed a significant radioprotective capacity for Mpg and a significant radio curative efficacy of olive oil. Combined effect of both treatments resulted in better control of the radiation induced disorders. Possible application on human subjects still awaits further investigations. 5 figs., 2 tabs.}
journal = []
issue = {2}
volume = {7}
journal type = {AC}
place = {Egypt}
year = {1986}
month = {Dec}
}
title = {Protective role of Mpg and Olive Oil against hazard of whole body gamma irradiation 3. immune system, survival rate and spleen histopathology in albino mice.}
author = {El-Bialy, M G, El-Kady, M H, El-Aaser, A A, and Mahmoud, K E}
abstractNote = {In the present study, investigations have been undertaken on the effect of whole body gamma irradiation of swiss albino mice, at the lethal dose level of 8 Gy, on the morphological appearance, mortality rate, immune system and histopathological pattern of spleen. Attempts have been made to screen the prophylactic and/or the curative effect of the sulfhydryl-bearing chemical compound; Mpg (Thiols) and/or the product; olive oil; against the radiation induced disorders on the above mentioned parameters. In the course of investigations carried out on the immune system, emphasis has been given to rosette forming cells from spleen lymphocytes. Whole irradiation demonstrated symptoms of radiation sickness. Morphological observations showed shivering, epilation, diarrhea, retarded physical activity and potentiated mortality rate. Response of immune system has been manifested by drastic retardation in rosette forming cells from spleen lymphocytes. Histopathological examinations showed significant structural changes in spleen tissues. Application of Mpg or olive oil, individually or successively, showed a significant radioprotective capacity for Mpg and a significant radio curative efficacy of olive oil. Combined effect of both treatments resulted in better control of the radiation induced disorders. Possible application on human subjects still awaits further investigations. 5 figs., 2 tabs.}
journal = []
issue = {2}
volume = {7}
journal type = {AC}
place = {Egypt}
year = {1986}
month = {Dec}
}