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Overexpression of thyroid hormone beta1 nuclear receptor is associated with an increased proliferation of human hepatoma cells

Conference:

Abstract

It is evaluated the expression of thyroid hormone nuclear receptors (TRs) and their possible roles in the carcinogenesis of human hepatocarcinoma. The expression of TR{beta}1 and TR{alpha} genes was evaluated at both the mRNA and protein levels. The expression of TR{beta}1 and TR{alpha}1 mRNAs is similar to those found in normal liver. However, the expression of TR isoform proteins depends on the cell-type. The expression of TRaplha1 protein is low in all cell lines examined. However, TR{Beta}1 protein is overexpressed in Mahlavu, SK-Hep-1, and HA22T, moderately expressed in J5, J7, and J328 and is very low HepG2, Hep3B, and PLC/PRF/5 cells. The proliferation of cells in which TR{beta}1 is overexpressed is stimulated by the thyroid hormone, 3,3`,5- triiodo-L-thyronine. These results suggest that TR{beta}1, not TR{alpha}1, is probably involved in the prolifaration of hepatoma cells.
Authors:
Lin, K; Lin, Y; McPhie, P; [1]  Cheng, S [2] 
  1. Chang-Gung College of Medicine and Technology, Graduate Institute of Clinical Medicine, Taoyuan (Taiwan, Province of China)
  2. National Cancer Inst., Bethesda, MD (United States)
Publication Date:
Dec 31, 1994
Product Type:
Conference
Report Number:
CONF-9410407-
Reference Number:
SCA: 550600; PA: ITA-96:000061; EDB-96:020904; SN: 96001510083
Resource Relation:
Conference: 16. international cancer conference, New Delhi (India), 30 Oct - 5 Nov 1994; Other Information: PBD: 1994; Related Information: Is Part Of Proceedings of 16th international cancer congress: Free papers and posters: New Delhi (India), October 30 - November 5, 1994; Rao, R.S.; Deo, M.G.; Sanghvi, L.D.; Mittra, I. [eds.]; PB: 2760 p.
Subject:
55 BIOLOGY AND MEDICINE, BASIC STUDIES; CARCINOGENESIS; HEPATOMAS; THYROID HORMONES; RECEPTORS; CELL PROLIFERATION
OSTI ID:
168559
Country of Origin:
Italy
Language:
English
Other Identifying Numbers:
Other: ISBN 88-323-1030-9; TRN: IT9600061
Submitting Site:
ITA
Size:
pp. 615-622
Announcement Date:

Conference:

Citation Formats

Lin, K, Lin, Y, McPhie, P, and Cheng, S. Overexpression of thyroid hormone beta1 nuclear receptor is associated with an increased proliferation of human hepatoma cells. Italy: N. p., 1994. Web.
Lin, K, Lin, Y, McPhie, P, & Cheng, S. Overexpression of thyroid hormone beta1 nuclear receptor is associated with an increased proliferation of human hepatoma cells. Italy.
Lin, K, Lin, Y, McPhie, P, and Cheng, S. 1994. "Overexpression of thyroid hormone beta1 nuclear receptor is associated with an increased proliferation of human hepatoma cells." Italy.
@misc{etde_168559,
title = {Overexpression of thyroid hormone beta1 nuclear receptor is associated with an increased proliferation of human hepatoma cells}
author = {Lin, K, Lin, Y, McPhie, P, and Cheng, S}
abstractNote = {It is evaluated the expression of thyroid hormone nuclear receptors (TRs) and their possible roles in the carcinogenesis of human hepatocarcinoma. The expression of TR{beta}1 and TR{alpha} genes was evaluated at both the mRNA and protein levels. The expression of TR{beta}1 and TR{alpha}1 mRNAs is similar to those found in normal liver. However, the expression of TR isoform proteins depends on the cell-type. The expression of TRaplha1 protein is low in all cell lines examined. However, TR{Beta}1 protein is overexpressed in Mahlavu, SK-Hep-1, and HA22T, moderately expressed in J5, J7, and J328 and is very low HepG2, Hep3B, and PLC/PRF/5 cells. The proliferation of cells in which TR{beta}1 is overexpressed is stimulated by the thyroid hormone, 3,3`,5- triiodo-L-thyronine. These results suggest that TR{beta}1, not TR{alpha}1, is probably involved in the prolifaration of hepatoma cells.}
place = {Italy}
year = {1994}
month = {Dec}
}