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Functional MR mapping of higher cognitive brain functions; Neurofunktionelle MR-Bildgebung hoeherer kognitiver Leistungen des menschlichen Gehirns

Journal Article:

Abstract

Fifteen normal subjects were examined on a conventional 1.5-T MR system to visualize cortical activation during the performance of high-level cognitive tasks. A computer-controlled videoprojector was employed to present psychometrically optimized activation paradigms. Reaction times and error rates of the volunteers were acquired online during stimulus presentation. The time course of cortical activation was measured in a series of strongly T{sub 2}*-weighted gradient-echo images from three or four adjacent slices. For anatomical correlation, picture elements showing a stimulus-related significant signal increase were color-coded and superimposed on T{sub 1}-weighted spin-echo images. Analysis of the fMRI data revealed a subtle (range 2-5%), but statistically significant increase in signal intensity during the periods of induced cortical activation. Judgment of semantic relatedness of word pairs, for example, activated selectively cortical areas in left frontal and left temporal brain regions. The strength of cortex activation in the semantic task decreased significantly in the course of stimulus presentation and was paralleled by a decrease in the corresponding reaction times. With its move into the area of cognitive neuroscience, fMRI calls both for the careful design of activation schemes and for the acquisition of behavioral data. For example, brain regions involved in language processing could only be  More>>
Authors:
Bellemann, M E; [1]  Spitzer, M; [2]  Brix, G; [1]  Kammer, T; [2]  Loose, R; [3]  Schwartz, A; [4]  Gueckel, F [3] 
  1. Deutsches Krebsforschungszentrum, Heidelberg (Germany). Forschungsschwerpunkt Radiologische Diagnostik und Therapie
  2. Psychiatrische Universitaetsklinik, Heidelberg (Germany). Sektion Experimentelle Psychopathologie
  3. Heidelberg Univ., Mannheim (Germany). Inst. fuer Klinische Radiologie
  4. Heidelberg Univ., Mannheim (Germany). Neurologische Klinik
Publication Date:
Apr 01, 1995
Product Type:
Journal Article
Reference Number:
SCA: 550602; PA: DEN-95:0FL024; EDB-95:151128; SN: 95001485160
Resource Relation:
Journal Name: Radiologe; Journal Volume: 35; Journal Issue: 4; Other Information: PBD: Apr 1995
Subject:
55 BIOLOGY AND MEDICINE, BASIC STUDIES; BRAIN; NMR IMAGING; CEREBRAL CORTEX; MAPPING; STIMULATION; IMAGES; OPTIMIZATION; MAN; BIOLOGICAL FUNCTIONS; NEUROLOGY
OSTI ID:
120172
Country of Origin:
Germany
Language:
German
Other Identifying Numbers:
Journal ID: RDLGBC; ISSN 0033-832X; TRN: DE95FL024
Submitting Site:
DEN
Size:
pp. 272-282
Announcement Date:

Journal Article:

Citation Formats

Bellemann, M E, Spitzer, M, Brix, G, Kammer, T, Loose, R, Schwartz, A, and Gueckel, F. Functional MR mapping of higher cognitive brain functions; Neurofunktionelle MR-Bildgebung hoeherer kognitiver Leistungen des menschlichen Gehirns. Germany: N. p., 1995. Web.
Bellemann, M E, Spitzer, M, Brix, G, Kammer, T, Loose, R, Schwartz, A, & Gueckel, F. Functional MR mapping of higher cognitive brain functions; Neurofunktionelle MR-Bildgebung hoeherer kognitiver Leistungen des menschlichen Gehirns. Germany.
Bellemann, M E, Spitzer, M, Brix, G, Kammer, T, Loose, R, Schwartz, A, and Gueckel, F. 1995. "Functional MR mapping of higher cognitive brain functions; Neurofunktionelle MR-Bildgebung hoeherer kognitiver Leistungen des menschlichen Gehirns." Germany.
@misc{etde_120172,
title = {Functional MR mapping of higher cognitive brain functions; Neurofunktionelle MR-Bildgebung hoeherer kognitiver Leistungen des menschlichen Gehirns}
author = {Bellemann, M E, Spitzer, M, Brix, G, Kammer, T, Loose, R, Schwartz, A, and Gueckel, F}
abstractNote = {Fifteen normal subjects were examined on a conventional 1.5-T MR system to visualize cortical activation during the performance of high-level cognitive tasks. A computer-controlled videoprojector was employed to present psychometrically optimized activation paradigms. Reaction times and error rates of the volunteers were acquired online during stimulus presentation. The time course of cortical activation was measured in a series of strongly T{sub 2}*-weighted gradient-echo images from three or four adjacent slices. For anatomical correlation, picture elements showing a stimulus-related significant signal increase were color-coded and superimposed on T{sub 1}-weighted spin-echo images. Analysis of the fMRI data revealed a subtle (range 2-5%), but statistically significant increase in signal intensity during the periods of induced cortical activation. Judgment of semantic relatedness of word pairs, for example, activated selectively cortical areas in left frontal and left temporal brain regions. The strength of cortex activation in the semantic task decreased significantly in the course of stimulus presentation and was paralleled by a decrease in the corresponding reaction times. With its move into the area of cognitive neuroscience, fMRI calls both for the careful design of activation schemes and for the acquisition of behavioral data. For example, brain regions involved in language processing could only be identified clearly when psychometrically matched activation paradigms were employed. The reaction time data correlated well with selective learning and thus helped to facilitate interpretation of the fMRI data sets. (orig.) [Deutsch] Zur Abbildung kortikaler Strukturen, die durch die Bearbeitung hoeherer kognitiver Aufgaben aktiviert werden, wurden 15 gesunde Probanden an einem konventionellen 1,5-Tesla-MR-System untersucht. Psychometrisch optimierte Aktivierungsparadigmen wurden rechnergesteuert praesentiert und gleichzeitig Reaktionszeiten und Fehlerraten der Probanden erfasst. Der Zeitverlauf der kortikalen Aktivierung wurde in einer Serie von stark T{sub 2}*-gewichteten Gradientenechobildern gemessen. Die fMRT-Daten zeigten einen subtilen (2-5%), aber statistisch signifiakten Signalanstieg waehrend der Phasen mit induzierter Hirnaktivitaet. Bei der Beurteilung von Wortpaaren hinsichtlich ihrer semantischen Verwandtschaft wurden selektiv Kortexareale im linken Frontal- und Temporallappen aktiviert. Die Staerke der neuronalen Aktivierung nahm - parallel zu den entsprechenden Reaktionszeiten - im Laufe der Praesentation des semantischen Stimulus signifikant ab. Nur durch den Einsatz psychometrisch optimierter Aktivierungsparadigmen konnten die Hirnareale, die in die Bearbeitung semanitischer Begriffe involviert sind, eindeutig identifiziert werden. Die Reaktionszeitdaten zeigten einen selektiven Lerneffekt beim semantischen Paradigma und erleichterten damit die Interpretation der fMRT-Bilder. (orig.)}
journal = {Radiologe}
issue = {4}
volume = {35}
journal type = {AC}
place = {Germany}
year = {1995}
month = {Apr}
}