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Autopsy cases of hepatocellular carcinoma in atomic bomb survivors

Journal Article:

Abstract

Since 1956, 388 autopsy cases of hepatocellular carcinoma (HCC) have been obtained at the Hiroshima Red Cross and A-Bomb Survivors Hospital, which consisted of those of proximately exposed 52 A-bomb survivors (mean age, 63.8 years), 105 distally exposed A-bomb survivors (mean age, 64.2 years), and the other 231 non-exposed patients (mean age, 60.6 years). Since 1985, the incidence of HCC tended to be higher in both proximately and distally exposed groups than the non-exposed group. There was no consistent tendency for the incidence of HCC by ages at autopsy and A-bombing. The incidence of liver cirrhosis was approximately 2 times higher in males than females in the non-exposed group, although no gender difference existed after 1981. In the exposed group, the incidence was similar in male and female groups. Approximately 90% of HCC patients had coexistent liver cirrhosis. Liver cirrhosis was associated with HCC in 50-60%. No significant differences in these incidences were observed between the exposed and non-exposed groups. The proportion of liver cirrhosis associated with HCC became constant in patients over the age of 40 in the non-exposed group. In the exposed group, on the other hand, the proportion reached the peak in those in their fifties and  More>>
Authors:
Fujihara, Megumu; Kurihara, Kanji; Aimitsu, Shiomi; Yukaya, Hirofumi; [1]  Hamada, Tadao
  1. Hiroshima Red Cross Atomic Bomb Hospital (Japan)
Publication Date:
Dec 01, 1994
Product Type:
Journal Article
Reference Number:
SCA: 560151; PA: JPN-95:009373; EDB-95:144780; SN: 95001481569
Resource Relation:
Journal Name: Nagasaki Igakkai Zasshi (Nagasaki Medical Journal); Journal Volume: 69; Journal Issue: suppl.; Other Information: PBD: Dec 1994
Subject:
56 BIOLOGY AND MEDICINE, APPLIED STUDIES; A-BOMB SURVIVORS; AUTOPSY; HEPATOMAS; LIVER; DISTANCE; DELAYED RADIATION EFFECTS; ANNUAL VARIATIONS; AGE GROUPS; SEX DEPENDENCE; DISEASE INCIDENCE; HIROSHIMA; SURVIVAL TIME
OSTI ID:
117520
Country of Origin:
Japan
Language:
Japanese
Other Identifying Numbers:
Journal ID: NAGZAC; ISSN 0369-3228; TRN: JP9509373
Submitting Site:
JPN
Size:
pp. 337-342
Announcement Date:

Journal Article:

Citation Formats

Fujihara, Megumu, Kurihara, Kanji, Aimitsu, Shiomi, Yukaya, Hirofumi, and Hamada, Tadao. Autopsy cases of hepatocellular carcinoma in atomic bomb survivors. Japan: N. p., 1994. Web.
Fujihara, Megumu, Kurihara, Kanji, Aimitsu, Shiomi, Yukaya, Hirofumi, & Hamada, Tadao. Autopsy cases of hepatocellular carcinoma in atomic bomb survivors. Japan.
Fujihara, Megumu, Kurihara, Kanji, Aimitsu, Shiomi, Yukaya, Hirofumi, and Hamada, Tadao. 1994. "Autopsy cases of hepatocellular carcinoma in atomic bomb survivors." Japan.
@misc{etde_117520,
title = {Autopsy cases of hepatocellular carcinoma in atomic bomb survivors}
author = {Fujihara, Megumu, Kurihara, Kanji, Aimitsu, Shiomi, Yukaya, Hirofumi, and Hamada, Tadao}
abstractNote = {Since 1956, 388 autopsy cases of hepatocellular carcinoma (HCC) have been obtained at the Hiroshima Red Cross and A-Bomb Survivors Hospital, which consisted of those of proximately exposed 52 A-bomb survivors (mean age, 63.8 years), 105 distally exposed A-bomb survivors (mean age, 64.2 years), and the other 231 non-exposed patients (mean age, 60.6 years). Since 1985, the incidence of HCC tended to be higher in both proximately and distally exposed groups than the non-exposed group. There was no consistent tendency for the incidence of HCC by ages at autopsy and A-bombing. The incidence of liver cirrhosis was approximately 2 times higher in males than females in the non-exposed group, although no gender difference existed after 1981. In the exposed group, the incidence was similar in male and female groups. Approximately 90% of HCC patients had coexistent liver cirrhosis. Liver cirrhosis was associated with HCC in 50-60%. No significant differences in these incidences were observed between the exposed and non-exposed groups. The proportion of liver cirrhosis associated with HCC became constant in patients over the age of 40 in the non-exposed group. In the exposed group, on the other hand, the proportion reached the peak in those in their fifties and sixties. Survival time tended to be longer in the exposed group than the non-exposed group. The patients in the non-exposed group tended to have histologically atypical type and metastases, as compared with those in the exposed group. (N.K.).}
journal = {Nagasaki Igakkai Zasshi (Nagasaki Medical Journal)}
issue = {suppl.}
volume = {69}
journal type = {AC}
place = {Japan}
year = {1994}
month = {Dec}
}