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Aluminum neurotoxicity in the rat brain

Abstract

To investigate the etiology of Alzheimer`s disease, we administered aluminum to healthy rats and examined the aluminum uptake in the brain and isolated brain cell nuclei by particle-induced X-ray emission (PIXE) analysis. Ten days after the last injection, Al was detected in the rat brain and in isolated brain cell nuclei by PIXE analysis. Al was also demonstrated in the brain after 15 months of oral aluminum administration. Moreover, Al was detected in the brain and isolated brain cell nuclei from the patients with Alzheimer`s disease. Silver impregnation studies revealed that spines attached to the dendritic processes of cortical nerve cells decreased remarkably after aluminum administration. Electron microscopy revealed characteristic inclusion bodies in the hippocampal nerve cells 75 days after the injection. These morphological changes in the rat brain after the aluminum administration were similar to those reportedly observed in the brain of Alzheimer`s disease patients. Our results indicate that Alzheimer`s disease is caused by irreversible accumulation of aluminum in the brain, as well as in the nuclei of brain cells. (author).
Authors:
Yumoto, S; [1]  Ohashi, H; Nagai, H; Kakimi, S; Ogawa, Y; Iwata, Y; Ishii, K
  1. Tokyo Univ. (Japan). Faculty of Medicine
Publication Date:
Dec 31, 1992
Product Type:
Journal Article
Report Number:
CONF-9207182-
Reference Number:
SCA: 553006; PA: JPN-95:009118; EDB-95:144724; SN: 95001481309
Resource Relation:
Journal Name: International Journal of PIXE; Journal Volume: 2; Journal Issue: 4; Conference: International symposium on BIO-PIXE, Sendai (Japan), 16-18 Jul 1992; Other Information: PBD: 1992
Subject:
55 BIOLOGY AND MEDICINE, BASIC STUDIES; PIXE ANALYSIS; BRAIN; ETIOLOGY; ALUMINIUM; RATS; UPTAKE; CELL NUCLEI; PATIENTS; NERVOUS SYSTEM DISEASES; TOXICITY
OSTI ID:
117277
Country of Origin:
Japan
Language:
English
Other Identifying Numbers:
Journal ID: IJPXET; ISSN 0129-0835; TRN: JP9509118
Submitting Site:
JPN
Size:
pp. 493-504
Announcement Date:

Citation Formats

Yumoto, S, Ohashi, H, Nagai, H, Kakimi, S, Ogawa, Y, Iwata, Y, and Ishii, K. Aluminum neurotoxicity in the rat brain. Japan: N. p., 1992. Web. doi:10.1142/S0129083592000531.
Yumoto, S, Ohashi, H, Nagai, H, Kakimi, S, Ogawa, Y, Iwata, Y, & Ishii, K. Aluminum neurotoxicity in the rat brain. Japan. doi:10.1142/S0129083592000531.
Yumoto, S, Ohashi, H, Nagai, H, Kakimi, S, Ogawa, Y, Iwata, Y, and Ishii, K. 1992. "Aluminum neurotoxicity in the rat brain." Japan. doi:10.1142/S0129083592000531. https://www.osti.gov/servlets/purl/10.1142/S0129083592000531.
@misc{etde_117277,
title = {Aluminum neurotoxicity in the rat brain}
author = {Yumoto, S, Ohashi, H, Nagai, H, Kakimi, S, Ogawa, Y, Iwata, Y, and Ishii, K}
abstractNote = {To investigate the etiology of Alzheimer`s disease, we administered aluminum to healthy rats and examined the aluminum uptake in the brain and isolated brain cell nuclei by particle-induced X-ray emission (PIXE) analysis. Ten days after the last injection, Al was detected in the rat brain and in isolated brain cell nuclei by PIXE analysis. Al was also demonstrated in the brain after 15 months of oral aluminum administration. Moreover, Al was detected in the brain and isolated brain cell nuclei from the patients with Alzheimer`s disease. Silver impregnation studies revealed that spines attached to the dendritic processes of cortical nerve cells decreased remarkably after aluminum administration. Electron microscopy revealed characteristic inclusion bodies in the hippocampal nerve cells 75 days after the injection. These morphological changes in the rat brain after the aluminum administration were similar to those reportedly observed in the brain of Alzheimer`s disease patients. Our results indicate that Alzheimer`s disease is caused by irreversible accumulation of aluminum in the brain, as well as in the nuclei of brain cells. (author).}
doi = {10.1142/S0129083592000531}
journal = {International Journal of PIXE}
issue = {4}
volume = {2}
journal type = {AC}
place = {Japan}
year = {1992}
month = {Dec}
}