Abstract
We have completed rapid syntheses of [{sup 18}F]butyrophenone neuroleptics ([{sup 18}F]haloperidol and [{sup 18}F]spiperone) from their nitro precursors in high radiochemical yields (up to 21%) by combining a one-step nitro-fluoro exchange reaction and a novel high performance liquid chromatography (HPLC) separation method. The synthesis time was ca. 95 min and both the radiochemical and chemical purities of the labeled products were over 99%. (author).
Hashizume, Kazunari;
Hashimoto, Naoto;
Kato, Hiroo;
Cork, D G;
Miyake, Yoshihiro
[1]
- National Cardiovascular Center, Suita, Osaka (Japan)
Citation Formats
Hashizume, Kazunari, Hashimoto, Naoto, Kato, Hiroo, Cork, D G, and Miyake, Yoshihiro.
The rapid synthesis of high purity [{sup 18}F]butyrophenone neuroleptics from nitro precursors for PET study.
Japan: N. p.,
1995.
Web.
doi:10.1246/cl.1995.303.
Hashizume, Kazunari, Hashimoto, Naoto, Kato, Hiroo, Cork, D G, & Miyake, Yoshihiro.
The rapid synthesis of high purity [{sup 18}F]butyrophenone neuroleptics from nitro precursors for PET study.
Japan.
https://doi.org/10.1246/cl.1995.303
Hashizume, Kazunari, Hashimoto, Naoto, Kato, Hiroo, Cork, D G, and Miyake, Yoshihiro.
1995.
"The rapid synthesis of high purity [{sup 18}F]butyrophenone neuroleptics from nitro precursors for PET study."
Japan.
https://doi.org/10.1246/cl.1995.303.
@misc{etde_109062,
title = {The rapid synthesis of high purity [{sup 18}F]butyrophenone neuroleptics from nitro precursors for PET study}
author = {Hashizume, Kazunari, Hashimoto, Naoto, Kato, Hiroo, Cork, D G, and Miyake, Yoshihiro}
abstractNote = {We have completed rapid syntheses of [{sup 18}F]butyrophenone neuroleptics ([{sup 18}F]haloperidol and [{sup 18}F]spiperone) from their nitro precursors in high radiochemical yields (up to 21%) by combining a one-step nitro-fluoro exchange reaction and a novel high performance liquid chromatography (HPLC) separation method. The synthesis time was ca. 95 min and both the radiochemical and chemical purities of the labeled products were over 99%. (author).}
doi = {10.1246/cl.1995.303}
journal = []
issue = {280}
journal type = {AC}
place = {Japan}
year = {1995}
month = {Apr}
}
title = {The rapid synthesis of high purity [{sup 18}F]butyrophenone neuroleptics from nitro precursors for PET study}
author = {Hashizume, Kazunari, Hashimoto, Naoto, Kato, Hiroo, Cork, D G, and Miyake, Yoshihiro}
abstractNote = {We have completed rapid syntheses of [{sup 18}F]butyrophenone neuroleptics ([{sup 18}F]haloperidol and [{sup 18}F]spiperone) from their nitro precursors in high radiochemical yields (up to 21%) by combining a one-step nitro-fluoro exchange reaction and a novel high performance liquid chromatography (HPLC) separation method. The synthesis time was ca. 95 min and both the radiochemical and chemical purities of the labeled products were over 99%. (author).}
doi = {10.1246/cl.1995.303}
journal = []
issue = {280}
journal type = {AC}
place = {Japan}
year = {1995}
month = {Apr}
}