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The rapid synthesis of high purity [{sup 18}F]butyrophenone neuroleptics from nitro precursors for PET study

Abstract

We have completed rapid syntheses of [{sup 18}F]butyrophenone neuroleptics ([{sup 18}F]haloperidol and [{sup 18}F]spiperone) from their nitro precursors in high radiochemical yields (up to 21%) by combining a one-step nitro-fluoro exchange reaction and a novel high performance liquid chromatography (HPLC) separation method. The synthesis time was ca. 95 min and both the radiochemical and chemical purities of the labeled products were over 99%. (author).
Authors:
Hashizume, Kazunari; Hashimoto, Naoto; Kato, Hiroo; Cork, D G; Miyake, Yoshihiro [1] 
  1. National Cardiovascular Center, Suita, Osaka (Japan)
Publication Date:
Apr 01, 1995
Product Type:
Journal Article
Reference Number:
SCA: 400703; PA: JPN-95:008048; EDB-95:136990; SN: 95001467475
Resource Relation:
Journal Name: Chemistry Letters (Tokyo); Journal Issue: 280; Other Information: PBD: Apr 1995
Subject:
40 CHEMISTRY; FLUORINE 18; RADIOPHARMACEUTICALS; POSITRON COMPUTED TOMOGRAPHY; LIQUID COLUMN CHROMATOGRAPHY; DOPAMINE; CHEMICAL PREPARATION; ORGANIC FLUORINE COMPOUNDS
OSTI ID:
109062
Country of Origin:
Japan
Language:
English
Other Identifying Numbers:
Journal ID: CMLTAG; ISSN 0366-7022; TRN: JP9508048
Submitting Site:
JPN
Size:
pp. 303-304
Announcement Date:
Oct 25, 1995

Citation Formats

Hashizume, Kazunari, Hashimoto, Naoto, Kato, Hiroo, Cork, D G, and Miyake, Yoshihiro. The rapid synthesis of high purity [{sup 18}F]butyrophenone neuroleptics from nitro precursors for PET study. Japan: N. p., 1995. Web. doi:10.1246/cl.1995.303.
Hashizume, Kazunari, Hashimoto, Naoto, Kato, Hiroo, Cork, D G, & Miyake, Yoshihiro. The rapid synthesis of high purity [{sup 18}F]butyrophenone neuroleptics from nitro precursors for PET study. Japan. doi:10.1246/cl.1995.303.
Hashizume, Kazunari, Hashimoto, Naoto, Kato, Hiroo, Cork, D G, and Miyake, Yoshihiro. 1995. "The rapid synthesis of high purity [{sup 18}F]butyrophenone neuroleptics from nitro precursors for PET study." Japan. doi:10.1246/cl.1995.303. https://www.osti.gov/servlets/purl/10.1246/cl.1995.303.
@misc{etde_109062,
title = {The rapid synthesis of high purity [{sup 18}F]butyrophenone neuroleptics from nitro precursors for PET study}
author = {Hashizume, Kazunari, Hashimoto, Naoto, Kato, Hiroo, Cork, D G, and Miyake, Yoshihiro}
abstractNote = {We have completed rapid syntheses of [{sup 18}F]butyrophenone neuroleptics ([{sup 18}F]haloperidol and [{sup 18}F]spiperone) from their nitro precursors in high radiochemical yields (up to 21%) by combining a one-step nitro-fluoro exchange reaction and a novel high performance liquid chromatography (HPLC) separation method. The synthesis time was ca. 95 min and both the radiochemical and chemical purities of the labeled products were over 99%. (author).}
doi = {10.1246/cl.1995.303}
journal = {Chemistry Letters (Tokyo)}
issue = {280}
journal type = {AC}
place = {Japan}
year = {1995}
month = {Apr}
}