Abstract
Psycho pharmacology has been discovering much about the D 2 dopamine receptors and their interrelationship to brain pathologies such as Parkinson`s Disease, Schizophrenia and Huntington Disease. Those biological receptors have got affinity with dopamine endogenous agent, so that they complex and, in non pathological individuals, the biological receptors contribute to bring the levels of dopamine and free acetylcholine into equilibrium. The Spiperon Dithiocarbamate (SPDC) from Spiperon is synthesized and its complexation with Technetium-99 m has been prepared with its reaction parameters after being studied and improved. The SPDC- {sup 99m} Tc complex biological distribution has been made in Wistar rats and the uptake of spleen, heart, liver, stomach, lung, kidney, blood, intestine and brain have been resolved. The plasmatic clearance curve has been based on Wistar rats data and the Know-how of the kit ( for label SPDC with {sup 99m} Tc) has been achieved. (author).
Citation Formats
Goncalves, M M.
Spiperone dithiocarbamate- {sup 99m}Tc kit - a potential diagnosis agent for dopaminergic D-2 brain pathologies - biodistribution; Preparacao e distribuicao biologica do complexo ditiocarbamato de espiperona-{sup 99m}Tc, agente diagnostico potencial de patologias cerebrais relacionadas aos receptores D-2 apresentado sob forma de conjunto de reativos para marcacao in situ.
Brazil: N. p.,
1993.
Web.
Goncalves, M M.
Spiperone dithiocarbamate- {sup 99m}Tc kit - a potential diagnosis agent for dopaminergic D-2 brain pathologies - biodistribution; Preparacao e distribuicao biologica do complexo ditiocarbamato de espiperona-{sup 99m}Tc, agente diagnostico potencial de patologias cerebrais relacionadas aos receptores D-2 apresentado sob forma de conjunto de reativos para marcacao in situ.
Brazil.
Goncalves, M M.
1993.
"Spiperone dithiocarbamate- {sup 99m}Tc kit - a potential diagnosis agent for dopaminergic D-2 brain pathologies - biodistribution; Preparacao e distribuicao biologica do complexo ditiocarbamato de espiperona-{sup 99m}Tc, agente diagnostico potencial de patologias cerebrais relacionadas aos receptores D-2 apresentado sob forma de conjunto de reativos para marcacao in situ."
Brazil.
@misc{etde_10157099,
title = {Spiperone dithiocarbamate- {sup 99m}Tc kit - a potential diagnosis agent for dopaminergic D-2 brain pathologies - biodistribution; Preparacao e distribuicao biologica do complexo ditiocarbamato de espiperona-{sup 99m}Tc, agente diagnostico potencial de patologias cerebrais relacionadas aos receptores D-2 apresentado sob forma de conjunto de reativos para marcacao in situ}
author = {Goncalves, M M}
abstractNote = {Psycho pharmacology has been discovering much about the D 2 dopamine receptors and their interrelationship to brain pathologies such as Parkinson`s Disease, Schizophrenia and Huntington Disease. Those biological receptors have got affinity with dopamine endogenous agent, so that they complex and, in non pathological individuals, the biological receptors contribute to bring the levels of dopamine and free acetylcholine into equilibrium. The Spiperon Dithiocarbamate (SPDC) from Spiperon is synthesized and its complexation with Technetium-99 m has been prepared with its reaction parameters after being studied and improved. The SPDC- {sup 99m} Tc complex biological distribution has been made in Wistar rats and the uptake of spleen, heart, liver, stomach, lung, kidney, blood, intestine and brain have been resolved. The plasmatic clearance curve has been based on Wistar rats data and the Know-how of the kit ( for label SPDC with {sup 99m} Tc) has been achieved. (author).}
place = {Brazil}
year = {1993}
month = {Dec}
}
title = {Spiperone dithiocarbamate- {sup 99m}Tc kit - a potential diagnosis agent for dopaminergic D-2 brain pathologies - biodistribution; Preparacao e distribuicao biologica do complexo ditiocarbamato de espiperona-{sup 99m}Tc, agente diagnostico potencial de patologias cerebrais relacionadas aos receptores D-2 apresentado sob forma de conjunto de reativos para marcacao in situ}
author = {Goncalves, M M}
abstractNote = {Psycho pharmacology has been discovering much about the D 2 dopamine receptors and their interrelationship to brain pathologies such as Parkinson`s Disease, Schizophrenia and Huntington Disease. Those biological receptors have got affinity with dopamine endogenous agent, so that they complex and, in non pathological individuals, the biological receptors contribute to bring the levels of dopamine and free acetylcholine into equilibrium. The Spiperon Dithiocarbamate (SPDC) from Spiperon is synthesized and its complexation with Technetium-99 m has been prepared with its reaction parameters after being studied and improved. The SPDC- {sup 99m} Tc complex biological distribution has been made in Wistar rats and the uptake of spleen, heart, liver, stomach, lung, kidney, blood, intestine and brain have been resolved. The plasmatic clearance curve has been based on Wistar rats data and the Know-how of the kit ( for label SPDC with {sup 99m} Tc) has been achieved. (author).}
place = {Brazil}
year = {1993}
month = {Dec}
}