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RBE modifying factors

Abstract

Experimental studies, when carried out under well controlled experimental conditions and planned to investigate specific endpoints, can provide reliable information on many aspects of the biological action of radiation. In particular animal studies are suitable to help in determining the shapes of the dose response relationships for tumour induction, and the influence of dose rate, and in understanding the species and strain dependence, as well as the effect of factors such as sex, age and hormonal status. All these variables can diversely influence the biological response to radiations of different qualities, and thus the radiation biological effects (RBEs). These aspects are examined and discussed in this paper, with special attention being addressed to the tumour induction response of hemolymphopoietic and epithelial tissues such as liver and ovary, which have shown an appreciable degree of susceptibility to radiation carcinogenesis.
Publication Date:
Dec 31, 1992
Product Type:
Technical Report
Report Number:
ETDE-IT-93-86
Reference Number:
SCA: 560152; 560101; PA: ITAN-93:000191; SN: 93000967090
Resource Relation:
Other Information: PBD: 1992
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 61 RADIATION PROTECTION AND DOSIMETRY; ANIMAL CELLS; BIOLOGICAL RADIATION EFFECTS; RBE; RESPONSE MODIFYING FACTORS; SENSITIVITY ANALYSIS; NEOPLASMS; OVARIES; LIVER; DOSE-RESPONSE RELATIONSHIPS; RADIONUCLIDE KINETICS; DOSE RATES; 560152; 560101; ANIMALS; DOSIMETRY AND MONITORING
OSTI ID:
10139015
Research Organizations:
ENEA, Casaccia (Italy). Area Energia Ambiente e Salute
Country of Origin:
Italy
Language:
English
Other Identifying Numbers:
Other: ON: DE93778186; TRN: 93:000191
Availability:
OSTI; NTIS (US Sales Only); INIS
Submitting Site:
ITAN
Size:
19 p.
Announcement Date:
Jul 05, 2005

Citation Formats

Coppola, M, Di Majo, V, Rebessi, S, and Covelli, V. RBE modifying factors. Italy: N. p., 1992. Web.
Coppola, M, Di Majo, V, Rebessi, S, & Covelli, V. RBE modifying factors. Italy.
Coppola, M, Di Majo, V, Rebessi, S, and Covelli, V. 1992. "RBE modifying factors." Italy.
@misc{etde_10139015,
title = {RBE modifying factors}
author = {Coppola, M, Di Majo, V, Rebessi, S, and Covelli, V}
abstractNote = {Experimental studies, when carried out under well controlled experimental conditions and planned to investigate specific endpoints, can provide reliable information on many aspects of the biological action of radiation. In particular animal studies are suitable to help in determining the shapes of the dose response relationships for tumour induction, and the influence of dose rate, and in understanding the species and strain dependence, as well as the effect of factors such as sex, age and hormonal status. All these variables can diversely influence the biological response to radiations of different qualities, and thus the radiation biological effects (RBEs). These aspects are examined and discussed in this paper, with special attention being addressed to the tumour induction response of hemolymphopoietic and epithelial tissues such as liver and ovary, which have shown an appreciable degree of susceptibility to radiation carcinogenesis.}
place = {Italy}
year = {1992}
month = {Dec}
}