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Model studies of radiation induced oxidation and reduction processes in DNA

Abstract

The papers presented in this thesis represent the major part of a systematic study of primary and secondary radiation induced damages in DNA. The magnetic resonance techniques EPR, ENDOR and FSE have been the experimental methods used. The study of radical formation in isolated DNA components under different environmental conditions demonstrates certain characteristics of the DNA components which are important in the study of DNA. It has been clearly demonstrated that the electrostatic environment, in particular the hydrogen bond pattern, is a vital factor for the secondary reaction scheme. Even radicals which are found in all related systems seem to be formed by different reaction pathways, depending upon the specific matrix. 92 refs., 2 figs., 6 tabs.
Authors:
Publication Date:
Dec 31, 1992
Product Type:
Thesis/Dissertation
Report Number:
NEI-NO-297
Reference Number:
SCA: 560120; PA: AIX-24:014645; SN: 93000943618
Resource Relation:
Other Information: DN: Reprints of eleven previously printed papers are attached.; TH: Thesis (Dr. Scient.).; PBD: 1992
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; DNA; CHEMICAL RADIATION EFFECTS; RADIATION CHEMISTRY; BIOLOGICAL MODELS; BIOSYNTHESIS; ELECTRON SPIN RESONANCE; ENDOR; IONIZING RADIATIONS; MONOCRYSTALS; PURINES; PYRIMIDINES; RADICALS; 560120; RADIATION EFFECTS ON BIOCHEMICALS, CELLS, AND TISSUE CULTURE
OSTI ID:
10130609
Research Organizations:
Oslo Univ. (Norway)
Country of Origin:
Norway
Language:
English
Other Identifying Numbers:
Other: ON: DE93614892; TRN: NO9200082014645
Availability:
OSTI; NTIS; INIS
Submitting Site:
NWN
Size:
192 p.
Announcement Date:
Jul 04, 2005

Citation Formats

Hole, E O. Model studies of radiation induced oxidation and reduction processes in DNA. Norway: N. p., 1992. Web.
Hole, E O. Model studies of radiation induced oxidation and reduction processes in DNA. Norway.
Hole, E O. 1992. "Model studies of radiation induced oxidation and reduction processes in DNA." Norway.
@misc{etde_10130609,
title = {Model studies of radiation induced oxidation and reduction processes in DNA}
author = {Hole, E O}
abstractNote = {The papers presented in this thesis represent the major part of a systematic study of primary and secondary radiation induced damages in DNA. The magnetic resonance techniques EPR, ENDOR and FSE have been the experimental methods used. The study of radical formation in isolated DNA components under different environmental conditions demonstrates certain characteristics of the DNA components which are important in the study of DNA. It has been clearly demonstrated that the electrostatic environment, in particular the hydrogen bond pattern, is a vital factor for the secondary reaction scheme. Even radicals which are found in all related systems seem to be formed by different reaction pathways, depending upon the specific matrix. 92 refs., 2 figs., 6 tabs.}
place = {Norway}
year = {1992}
month = {Dec}
}