Abstract
The frequency of mutant T lymphocytes defective in T-cell receptor gene ({alpha} or {beta}) expression was measured using the two-color flow cytometric technique. Results for a total of 203 atomic bomb survivors, 78 of whom were proximally exposed (DS86 doses of {>=} 1.5 Gy) and 125 of whom were distally exposed (DS86 doses of < 0.005 Gy), showed that the mutant frequency was significantly higher in males than in females. No significant dose effects were observed. In contrast, a significant increase of mutant frequency was observed for six patients treated with Thorotrast, a contrast medium containing {sup 228}Th formerly used for radiodiagnosis. In addition, thyroid disease patients treated with {sup 131}I showed a dose-related increase of mutant frequency. It was suggested that the present T-cell receptor mutation assay has a unique characteristic as a biological dosimeter for the measurement of recent exposures to genotoxic agents. (author).
Citation Formats
Kyoizumi, Seishi, Umeki, Shigeko, and Akiyama, Mitoshi.
Frequency of mutant T lymphocytes defective in the expression of the T-cell antigen receptor gene among radiation-exposed people.
Japan: N. p.,
1991.
Web.
Kyoizumi, Seishi, Umeki, Shigeko, & Akiyama, Mitoshi.
Frequency of mutant T lymphocytes defective in the expression of the T-cell antigen receptor gene among radiation-exposed people.
Japan.
Kyoizumi, Seishi, Umeki, Shigeko, and Akiyama, Mitoshi.
1991.
"Frequency of mutant T lymphocytes defective in the expression of the T-cell antigen receptor gene among radiation-exposed people."
Japan.
@misc{etde_10126156,
title = {Frequency of mutant T lymphocytes defective in the expression of the T-cell antigen receptor gene among radiation-exposed people}
author = {Kyoizumi, Seishi, Umeki, Shigeko, and Akiyama, Mitoshi}
abstractNote = {The frequency of mutant T lymphocytes defective in T-cell receptor gene ({alpha} or {beta}) expression was measured using the two-color flow cytometric technique. Results for a total of 203 atomic bomb survivors, 78 of whom were proximally exposed (DS86 doses of {>=} 1.5 Gy) and 125 of whom were distally exposed (DS86 doses of < 0.005 Gy), showed that the mutant frequency was significantly higher in males than in females. No significant dose effects were observed. In contrast, a significant increase of mutant frequency was observed for six patients treated with Thorotrast, a contrast medium containing {sup 228}Th formerly used for radiodiagnosis. In addition, thyroid disease patients treated with {sup 131}I showed a dose-related increase of mutant frequency. It was suggested that the present T-cell receptor mutation assay has a unique characteristic as a biological dosimeter for the measurement of recent exposures to genotoxic agents. (author).}
place = {Japan}
year = {1991}
month = {Jun}
}
title = {Frequency of mutant T lymphocytes defective in the expression of the T-cell antigen receptor gene among radiation-exposed people}
author = {Kyoizumi, Seishi, Umeki, Shigeko, and Akiyama, Mitoshi}
abstractNote = {The frequency of mutant T lymphocytes defective in T-cell receptor gene ({alpha} or {beta}) expression was measured using the two-color flow cytometric technique. Results for a total of 203 atomic bomb survivors, 78 of whom were proximally exposed (DS86 doses of {>=} 1.5 Gy) and 125 of whom were distally exposed (DS86 doses of < 0.005 Gy), showed that the mutant frequency was significantly higher in males than in females. No significant dose effects were observed. In contrast, a significant increase of mutant frequency was observed for six patients treated with Thorotrast, a contrast medium containing {sup 228}Th formerly used for radiodiagnosis. In addition, thyroid disease patients treated with {sup 131}I showed a dose-related increase of mutant frequency. It was suggested that the present T-cell receptor mutation assay has a unique characteristic as a biological dosimeter for the measurement of recent exposures to genotoxic agents. (author).}
place = {Japan}
year = {1991}
month = {Jun}
}