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LET-effects in DNA

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Abstract

In this contribution, an introductory view on the physical properties of ions is given and the cellular response to high LET radiation is summarized. Then the measurements of strand break induction of DNA in solution and in intracellular DNA are reported and compared to cell survival. The possibility of changes in the quality of the lesions is discussed and finally the present status of model calculations in comparison to the experiments is given. (orig./HSI)
Authors:
Kraft, G; [1]  Taucher-Scholz, G; [1]  Heilmann, J [1] 
  1. Gesellschaft fuer Schwerionenforschung mbH, Darmstadt (Germany)
Publication Date:
Nov 01, 1994
Product Type:
Conference
Report Number:
GSI-94-78(prepr.); CONF-9410280-
Reference Number:
SCA: 560120; PA: DEN-95:0F2988; EDB-95:047436; SN: 95001351414
Resource Relation:
Conference: International workshop on radiation damage in DNA: relationships at early times,Gleneden, OR (United States),1-6 Oct 1994; Other Information: PBD: Nov 1994
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; DNA; LET; HEAVY IONS; BIOLOGICAL RADIATION EFFECTS; CELL CULTURES; EXTERNAL IRRADIATION; ION BEAMS; SOLUTIONS; IN VITRO; SURVIVAL CURVES; PLASMIDS; BIOLOGICAL MODELS; 560120; RADIATION EFFECTS ON BIOCHEMICALS, CELLS, AND TISSUE CULTURE
OSTI ID:
10125483
Research Organizations:
Gesellschaft fuer Schwerionenforschung mbH, Darmstadt (Germany)
Country of Origin:
Germany
Language:
English
Other Identifying Numbers:
Other: ON: DE95752099; TRN: DE95F2988
Availability:
OSTI; NTIS (US Sales Only); INIS
Submitting Site:
DEN
Size:
15 p.
Announcement Date:
Mar 28, 1995

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Citation Formats

Kraft, G, Taucher-Scholz, G, and Heilmann, J. LET-effects in DNA. Germany: N. p., 1994. Web.
Kraft, G, Taucher-Scholz, G, & Heilmann, J. LET-effects in DNA. Germany.
Kraft, G, Taucher-Scholz, G, and Heilmann, J. 1994. "LET-effects in DNA." Germany.
@misc{etde_10125483,
title = {LET-effects in DNA}
 author = {Kraft, G, Taucher-Scholz, G, and Heilmann, J}
 abstractNote = {In this contribution, an introductory view on the physical properties of ions is given and the cellular response to high LET radiation is summarized. Then the measurements of strand break induction of DNA in solution and in intracellular DNA are reported and compared to cell survival. The possibility of changes in the quality of the lesions is discussed and finally the present status of model calculations in comparison to the experiments is given. (orig./HSI)}
 place = {Germany}
 year = {1994}
 month = {Nov}
 }