Abstract
An {sup 125}I-labelled monoclonal antibody specific for {alpha}-granule membrane protein (GMP-140) of platelets was used to determine the platelet activation of 12 cases of regular hemodialysis. Platelet counts decreased from 16.6 {+-} 1.8 x 10{sup 10}/L{sup -1} to 8.7 {+-} 2.4 x 10{sup 10}/L{sup -1} during the first 2 h of the dialysis. The numbers of GMP-140 molecules on the platelet surface began to increase at 30 min after the initiation of dialysis, reaching the top at 2 h to 3 h. The alteration of TXB{sub 2} concentration in plasma was consistent with the change of GMP-140 began to increase at 3 h after the initiation of dialysis, reaching the top at 4 h. The concentration of {delta}-TG in plasma decreased at the early stage and increased at the late stage of hemodialysis. These results demonstrated the existence of significant transient platelet activation in the process of hemodialysis.
Citation Formats
Fugang, Li, Guoxin, Wu, and Changgeng, Ruan.
Determination of platelet activation in the process of hemodialysis with {sup 125}I-labelled monoclonal antibody against activated platelets.
China: N. p.,
1991.
Web.
Fugang, Li, Guoxin, Wu, & Changgeng, Ruan.
Determination of platelet activation in the process of hemodialysis with {sup 125}I-labelled monoclonal antibody against activated platelets.
China.
Fugang, Li, Guoxin, Wu, and Changgeng, Ruan.
1991.
"Determination of platelet activation in the process of hemodialysis with {sup 125}I-labelled monoclonal antibody against activated platelets."
China.
@misc{etde_10118884,
title = {Determination of platelet activation in the process of hemodialysis with {sup 125}I-labelled monoclonal antibody against activated platelets}
author = {Fugang, Li, Guoxin, Wu, and Changgeng, Ruan}
abstractNote = {An {sup 125}I-labelled monoclonal antibody specific for {alpha}-granule membrane protein (GMP-140) of platelets was used to determine the platelet activation of 12 cases of regular hemodialysis. Platelet counts decreased from 16.6 {+-} 1.8 x 10{sup 10}/L{sup -1} to 8.7 {+-} 2.4 x 10{sup 10}/L{sup -1} during the first 2 h of the dialysis. The numbers of GMP-140 molecules on the platelet surface began to increase at 30 min after the initiation of dialysis, reaching the top at 2 h to 3 h. The alteration of TXB{sub 2} concentration in plasma was consistent with the change of GMP-140 began to increase at 3 h after the initiation of dialysis, reaching the top at 4 h. The concentration of {delta}-TG in plasma decreased at the early stage and increased at the late stage of hemodialysis. These results demonstrated the existence of significant transient platelet activation in the process of hemodialysis.}
place = {China}
year = {1991}
month = {Dec}
}
title = {Determination of platelet activation in the process of hemodialysis with {sup 125}I-labelled monoclonal antibody against activated platelets}
author = {Fugang, Li, Guoxin, Wu, and Changgeng, Ruan}
abstractNote = {An {sup 125}I-labelled monoclonal antibody specific for {alpha}-granule membrane protein (GMP-140) of platelets was used to determine the platelet activation of 12 cases of regular hemodialysis. Platelet counts decreased from 16.6 {+-} 1.8 x 10{sup 10}/L{sup -1} to 8.7 {+-} 2.4 x 10{sup 10}/L{sup -1} during the first 2 h of the dialysis. The numbers of GMP-140 molecules on the platelet surface began to increase at 30 min after the initiation of dialysis, reaching the top at 2 h to 3 h. The alteration of TXB{sub 2} concentration in plasma was consistent with the change of GMP-140 began to increase at 3 h after the initiation of dialysis, reaching the top at 4 h. The concentration of {delta}-TG in plasma decreased at the early stage and increased at the late stage of hemodialysis. These results demonstrated the existence of significant transient platelet activation in the process of hemodialysis.}
place = {China}
year = {1991}
month = {Dec}
}