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Determination of platelet activation in the process of hemodialysis with {sup 125}I-labelled monoclonal antibody against activated platelets

Technical Report:

Abstract

An {sup 125}I-labelled monoclonal antibody specific for {alpha}-granule membrane protein (GMP-140) of platelets was used to determine the platelet activation of 12 cases of regular hemodialysis. Platelet counts decreased from 16.6 {+-} 1.8 x 10{sup 10}/L{sup -1} to 8.7 {+-} 2.4 x 10{sup 10}/L{sup -1} during the first 2 h of the dialysis. The numbers of GMP-140 molecules on the platelet surface began to increase at 30 min after the initiation of dialysis, reaching the top at 2 h to 3 h. The alteration of TXB{sub 2} concentration in plasma was consistent with the change of GMP-140 began to increase at 3 h after the initiation of dialysis, reaching the top at 4 h. The concentration of {delta}-TG in plasma decreased at the early stage and increased at the late stage of hemodialysis. These results demonstrated the existence of significant transient platelet activation in the process of hemodialysis.
Authors:
Fugang, Li; Guoxin, Wu; Changgeng, Ruan [1] 
  1. Suzhou Medical Coll. (China)
Publication Date:
Dec 01, 1991
Product Type:
Technical Report
Report Number:
CNIC-00554; SMC-0068.
Reference Number:
SCA: 550601; PA: AIX-24:006522; SN: 93000931489
Resource Relation:
Other Information: PBD: Dec 1991
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BLOOD PLATELETS; CHEMICAL ACTIVATION; MONOCLONAL ANTIBODIES; DIALYSIS; EXCITATION; IODINE 125; LABELLED COMPOUNDS; 550601; UNSEALED RADIONUCLIDES IN DIAGNOSTICS
OSTI ID:
10118884
Research Organizations:
China Nuclear Information Centre, Beijing, BJ (China)
Country of Origin:
China
Language:
Chinese
Other Identifying Numbers:
Other: ON: DE93611953; ISBN 7-5022-0596-9; TRN: CN9201682006522
Availability:
OSTI; NTIS (US Sales Only); INIS
Submitting Site:
INIS
Size:
[8] p.
Announcement Date:
Jun 30, 2005

Technical Report:

Citation Formats

Fugang, Li, Guoxin, Wu, and Changgeng, Ruan. Determination of platelet activation in the process of hemodialysis with {sup 125}I-labelled monoclonal antibody against activated platelets. China: N. p., 1991. Web.
Fugang, Li, Guoxin, Wu, & Changgeng, Ruan. Determination of platelet activation in the process of hemodialysis with {sup 125}I-labelled monoclonal antibody against activated platelets. China.
Fugang, Li, Guoxin, Wu, and Changgeng, Ruan. 1991. "Determination of platelet activation in the process of hemodialysis with {sup 125}I-labelled monoclonal antibody against activated platelets." China.
@misc{etde_10118884,
title = {Determination of platelet activation in the process of hemodialysis with {sup 125}I-labelled monoclonal antibody against activated platelets}
author = {Fugang, Li, Guoxin, Wu, and Changgeng, Ruan}
abstractNote = {An {sup 125}I-labelled monoclonal antibody specific for {alpha}-granule membrane protein (GMP-140) of platelets was used to determine the platelet activation of 12 cases of regular hemodialysis. Platelet counts decreased from 16.6 {+-} 1.8 x 10{sup 10}/L{sup -1} to 8.7 {+-} 2.4 x 10{sup 10}/L{sup -1} during the first 2 h of the dialysis. The numbers of GMP-140 molecules on the platelet surface began to increase at 30 min after the initiation of dialysis, reaching the top at 2 h to 3 h. The alteration of TXB{sub 2} concentration in plasma was consistent with the change of GMP-140 began to increase at 3 h after the initiation of dialysis, reaching the top at 4 h. The concentration of {delta}-TG in plasma decreased at the early stage and increased at the late stage of hemodialysis. These results demonstrated the existence of significant transient platelet activation in the process of hemodialysis.}
place = {China}
year = {1991}
month = {Dec}
}