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Radioprotective effect of antioxidants on human blood lymphocytes

Technical Report:

Abstract

By using an improved fluorometric method with 2-thiobarbituric acid (TBA) as fluorometric agent, the antiradiation effects of four kinds of antioxidants on {sup 60}Co {gamma}-ray irradiation inducing final products of lipid peroxides (LPO), i.e. malodialdehyde (MDA) content changes in human blood lymphocytes, were investigated with LPO value as an indicator. The results of the experiment were as following: (1)The radioprotective effect of exogenous antioxidants added to human blood lymphocytes on radiation-induced LPO damage of cellular membrane were remarkable; (2)The radioprotective beneficial sequences of four kinds of antioxidants were arranged like this: SOD > VE >VC, Se{sup 4+}; (3)Radioprotective effects of antioxidants on radiation-induced damage varied especially with the property of antioxidants, drug concentration, and pretreatment and monitoring time, etc., as well as irradiated dosage and various kinds of incubated cells. In addition, the mechanism of these antioxidants as radioprotectants on human blood lymphocytes is discussed in connection with LPO damage and radioprotection.
Authors:
Mingsuo, Wang; Xuandi, Gu; Genbo, Zhu; Jixing, Feng; Liaoyuan, Su [1] 
  1. Suzhou Medical Coll. (China)
Publication Date:
Sep 01, 1991
Product Type:
Technical Report
Report Number:
CNIC-00501; SMC-0061.
Reference Number:
SCA: 560120; PA: AIX-24:005757; SN: 93000930892
Resource Relation:
Other Information: PBD: Sep 1991
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; ANTIOXIDANTS; RADIATION PROTECTION; RADIOPROTECTIVE SUBSTANCES; LYMPHOCYTES; RADIATION INJURIES; BLOOD; CELL CULTURES; CELL MEMBRANES; GAMMA RADIATION; MAN; 560120; RADIATION EFFECTS ON BIOCHEMICALS, CELLS, AND TISSUE CULTURE
OSTI ID:
10118798
Research Organizations:
China Nuclear Information Centre, Beijing, BJ (China)
Country of Origin:
China
Language:
Chinese
Other Identifying Numbers:
Other: ON: DE93611419; ISBN 7-5022-0523-3; TRN: CN9201666005757
Availability:
OSTI; NTIS (US Sales Only); INIS
Submitting Site:
INIS
Size:
[6] p.
Announcement Date:
Jun 30, 2005

Technical Report:

Citation Formats

Mingsuo, Wang, Xuandi, Gu, Genbo, Zhu, Jixing, Feng, and Liaoyuan, Su. Radioprotective effect of antioxidants on human blood lymphocytes. China: N. p., 1991. Web.
Mingsuo, Wang, Xuandi, Gu, Genbo, Zhu, Jixing, Feng, & Liaoyuan, Su. Radioprotective effect of antioxidants on human blood lymphocytes. China.
Mingsuo, Wang, Xuandi, Gu, Genbo, Zhu, Jixing, Feng, and Liaoyuan, Su. 1991. "Radioprotective effect of antioxidants on human blood lymphocytes." China.
@misc{etde_10118798,
title = {Radioprotective effect of antioxidants on human blood lymphocytes}
author = {Mingsuo, Wang, Xuandi, Gu, Genbo, Zhu, Jixing, Feng, and Liaoyuan, Su}
abstractNote = {By using an improved fluorometric method with 2-thiobarbituric acid (TBA) as fluorometric agent, the antiradiation effects of four kinds of antioxidants on {sup 60}Co {gamma}-ray irradiation inducing final products of lipid peroxides (LPO), i.e. malodialdehyde (MDA) content changes in human blood lymphocytes, were investigated with LPO value as an indicator. The results of the experiment were as following: (1)The radioprotective effect of exogenous antioxidants added to human blood lymphocytes on radiation-induced LPO damage of cellular membrane were remarkable; (2)The radioprotective beneficial sequences of four kinds of antioxidants were arranged like this: SOD > VE >VC, Se{sup 4+}; (3)Radioprotective effects of antioxidants on radiation-induced damage varied especially with the property of antioxidants, drug concentration, and pretreatment and monitoring time, etc., as well as irradiated dosage and various kinds of incubated cells. In addition, the mechanism of these antioxidants as radioprotectants on human blood lymphocytes is discussed in connection with LPO damage and radioprotection.}
place = {China}
year = {1991}
month = {Sep}
}