Abstract
The {sup 99m}Tc-d,1-HM-PAO is an ideal radiopharmaceutical for regional cerebral blood perfusion imaging. The improvement of synthesis and separation of diastereoisomers leads to obtain high purity (>99%) of d, 1-HM-PAO and meso-HM-PAO. During separation H NMR spectroscopy was used to monitor the relative composition of these two diastereoisomers that can ensure the purity of pligand of d,1-HM-PAO. The intravenous injection of {sup 99m}Tc-d,1-HM-PAO was formed by adding fresh {sup 99m}Tc washing liquor into a sterile. Pyrogen-free and freeze-dried vial. The radiochemical purity (RCP) of {sup 99m}Tc-d,1-HM-PAO was greater than 80%. From the experiments of {sup 99m}Tc-d,1-HM-PAO in mice, after two minutes of intravenously (I>V>) administration about 2.24% of injected dose (I.D.)appeared in the brain, and after 24 hours about 72% of radioactivity of injected dose still left in the brain. But for the {sup 99m}Tc-meso-HM-PAO after two minutes of i.v. administration, about 1.93% of I.D. appeared in the brain, and 24 hours later, 25% of radioactivity of I.D. was in the brain. This result shows that in the brain the radioactivity of {sup 99m}Tc-meso-HM-PAO declines faster than that of {sup 99m}Td-d,1-HM-PAO.
Lanqin, Bai;
Jinjie, Huang;
Li, Fan;
Suzhen, Bai;
Guoli, Li;
Hui, Jing;
Lun, Xiao
[1]
- China Inst. of Atomic Energy, Beijing (China)
Citation Formats
Lanqin, Bai, Jinjie, Huang, Li, Fan, Suzhen, Bai, Guoli, Li, Hui, Jing, and Lun, Xiao.
The development of {sup 99m}Tc-d, 1-HM-PAO. A new radiopharmaceutical for regional cerebral blood perfusion imaging.
China: N. p.,
1991.
Web.
Lanqin, Bai, Jinjie, Huang, Li, Fan, Suzhen, Bai, Guoli, Li, Hui, Jing, & Lun, Xiao.
The development of {sup 99m}Tc-d, 1-HM-PAO. A new radiopharmaceutical for regional cerebral blood perfusion imaging.
China.
Lanqin, Bai, Jinjie, Huang, Li, Fan, Suzhen, Bai, Guoli, Li, Hui, Jing, and Lun, Xiao.
1991.
"The development of {sup 99m}Tc-d, 1-HM-PAO. A new radiopharmaceutical for regional cerebral blood perfusion imaging."
China.
@misc{etde_10118665,
title = {The development of {sup 99m}Tc-d, 1-HM-PAO. A new radiopharmaceutical for regional cerebral blood perfusion imaging}
author = {Lanqin, Bai, Jinjie, Huang, Li, Fan, Suzhen, Bai, Guoli, Li, Hui, Jing, and Lun, Xiao}
abstractNote = {The {sup 99m}Tc-d,1-HM-PAO is an ideal radiopharmaceutical for regional cerebral blood perfusion imaging. The improvement of synthesis and separation of diastereoisomers leads to obtain high purity (>99%) of d, 1-HM-PAO and meso-HM-PAO. During separation H NMR spectroscopy was used to monitor the relative composition of these two diastereoisomers that can ensure the purity of pligand of d,1-HM-PAO. The intravenous injection of {sup 99m}Tc-d,1-HM-PAO was formed by adding fresh {sup 99m}Tc washing liquor into a sterile. Pyrogen-free and freeze-dried vial. The radiochemical purity (RCP) of {sup 99m}Tc-d,1-HM-PAO was greater than 80%. From the experiments of {sup 99m}Tc-d,1-HM-PAO in mice, after two minutes of intravenously (I>V>) administration about 2.24% of injected dose (I.D.)appeared in the brain, and after 24 hours about 72% of radioactivity of injected dose still left in the brain. But for the {sup 99m}Tc-meso-HM-PAO after two minutes of i.v. administration, about 1.93% of I.D. appeared in the brain, and 24 hours later, 25% of radioactivity of I.D. was in the brain. This result shows that in the brain the radioactivity of {sup 99m}Tc-meso-HM-PAO declines faster than that of {sup 99m}Td-d,1-HM-PAO.}
place = {China}
year = {1991}
month = {Dec}
}
title = {The development of {sup 99m}Tc-d, 1-HM-PAO. A new radiopharmaceutical for regional cerebral blood perfusion imaging}
author = {Lanqin, Bai, Jinjie, Huang, Li, Fan, Suzhen, Bai, Guoli, Li, Hui, Jing, and Lun, Xiao}
abstractNote = {The {sup 99m}Tc-d,1-HM-PAO is an ideal radiopharmaceutical for regional cerebral blood perfusion imaging. The improvement of synthesis and separation of diastereoisomers leads to obtain high purity (>99%) of d, 1-HM-PAO and meso-HM-PAO. During separation H NMR spectroscopy was used to monitor the relative composition of these two diastereoisomers that can ensure the purity of pligand of d,1-HM-PAO. The intravenous injection of {sup 99m}Tc-d,1-HM-PAO was formed by adding fresh {sup 99m}Tc washing liquor into a sterile. Pyrogen-free and freeze-dried vial. The radiochemical purity (RCP) of {sup 99m}Tc-d,1-HM-PAO was greater than 80%. From the experiments of {sup 99m}Tc-d,1-HM-PAO in mice, after two minutes of intravenously (I>V>) administration about 2.24% of injected dose (I.D.)appeared in the brain, and after 24 hours about 72% of radioactivity of injected dose still left in the brain. But for the {sup 99m}Tc-meso-HM-PAO after two minutes of i.v. administration, about 1.93% of I.D. appeared in the brain, and 24 hours later, 25% of radioactivity of I.D. was in the brain. This result shows that in the brain the radioactivity of {sup 99m}Tc-meso-HM-PAO declines faster than that of {sup 99m}Td-d,1-HM-PAO.}
place = {China}
year = {1991}
month = {Dec}
}