Abstract
To develop {sup 99m}Tc instant labelling kit of d,1-HMPAO and {sup 131}I labelled IMP for the regional cerebral blood flow scintigraphic use, d,1-HMPAO and IMP were synthesized. The former was prepared from 2,3-butadione monoxim and 2,2-dimethyl-1,3-propanediamine in the presence of cation exchange resin, and then selective reduction of imine bond with sodium borohydride followed by fractional crystallization of diastereometric mixture of HMPAO. The latter was prepared by condensation of p-iodophenylpropanone with isopropylamine, and then reduction of double bond with sodium borohydride. For the preparation of {sup 99m}Tc labelled HSA, experiments on incorporation of bifunctional chelating agent of DTPA to HSA, establishment of optimal conditions of {sup 99m}Tc labelling, determination of labelling yield and radiochemical purity, and examination of stability were carried out. (Author).
Kim, Jae Rok;
Park, Kyung Bae;
Awh, Ok Doo
[1]
- Korea Atomic Energy Research Inst., Daeduk (Korea, Republic of)
Citation Formats
Kim, Jae Rok, Park, Kyung Bae, and Awh, Ok Doo.
Studies on the preparation of labelled compounds for {gamma}-scintigraphy use.
Korea, Republic of: N. p.,
1991.
Web.
Kim, Jae Rok, Park, Kyung Bae, & Awh, Ok Doo.
Studies on the preparation of labelled compounds for {gamma}-scintigraphy use.
Korea, Republic of.
Kim, Jae Rok, Park, Kyung Bae, and Awh, Ok Doo.
1991.
"Studies on the preparation of labelled compounds for {gamma}-scintigraphy use."
Korea, Republic of.
@misc{etde_10117479,
title = {Studies on the preparation of labelled compounds for {gamma}-scintigraphy use}
author = {Kim, Jae Rok, Park, Kyung Bae, and Awh, Ok Doo}
abstractNote = {To develop {sup 99m}Tc instant labelling kit of d,1-HMPAO and {sup 131}I labelled IMP for the regional cerebral blood flow scintigraphic use, d,1-HMPAO and IMP were synthesized. The former was prepared from 2,3-butadione monoxim and 2,2-dimethyl-1,3-propanediamine in the presence of cation exchange resin, and then selective reduction of imine bond with sodium borohydride followed by fractional crystallization of diastereometric mixture of HMPAO. The latter was prepared by condensation of p-iodophenylpropanone with isopropylamine, and then reduction of double bond with sodium borohydride. For the preparation of {sup 99m}Tc labelled HSA, experiments on incorporation of bifunctional chelating agent of DTPA to HSA, establishment of optimal conditions of {sup 99m}Tc labelling, determination of labelling yield and radiochemical purity, and examination of stability were carried out. (Author).}
place = {Korea, Republic of}
year = {1991}
month = {Mar}
}
title = {Studies on the preparation of labelled compounds for {gamma}-scintigraphy use}
author = {Kim, Jae Rok, Park, Kyung Bae, and Awh, Ok Doo}
abstractNote = {To develop {sup 99m}Tc instant labelling kit of d,1-HMPAO and {sup 131}I labelled IMP for the regional cerebral blood flow scintigraphic use, d,1-HMPAO and IMP were synthesized. The former was prepared from 2,3-butadione monoxim and 2,2-dimethyl-1,3-propanediamine in the presence of cation exchange resin, and then selective reduction of imine bond with sodium borohydride followed by fractional crystallization of diastereometric mixture of HMPAO. The latter was prepared by condensation of p-iodophenylpropanone with isopropylamine, and then reduction of double bond with sodium borohydride. For the preparation of {sup 99m}Tc labelled HSA, experiments on incorporation of bifunctional chelating agent of DTPA to HSA, establishment of optimal conditions of {sup 99m}Tc labelling, determination of labelling yield and radiochemical purity, and examination of stability were carried out. (Author).}
place = {Korea, Republic of}
year = {1991}
month = {Mar}
}