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Impact of MRI in the management and staging of cancer of the uterine cervix

Abstract

Background. Cervical carcinoma is the only gynecological tumor still being staged mainly by clinical examination and only a limited use of diagnostic radiology. Cross sectional imaging is increasingly used as an aid in the staging procedure. We wanted to assess the impact of magnetic resonance imaging (MRI) in addition to the clinical staging of patients with carcinoma of the uterine cervix. Material and methods. A retrospective single-centre analysis of 183 women referred to a tertiary referral centre for gynecological tumors (<= 65 years old) with cervical cancer diagnosed between January 1, 2003 and December 31, 2006 who have undergone an MRI investigation before start of treatment. Patient records were retrospectively reviewed and any change of the planned treatment after the MRI examination was noted. Results. In patients with cervical carcinoma FIGO stage Ia2-IIa treated surgically, the treatment plan was altered due to MRI results in 10/125 patients. In the smaller group of patients with clinically more advanced disease receiving radio-chemotherapy, the treatment plan was altered in 12/58 patients. Reasons for changing the treatment plan after MRI were findings indicating a higher (n = 8) or lower (n = 5) local tumor stage, findings of para aortic nodal disease (n =  More>>
Authors:
Stenstedt, Kristina; [1]  Hellstroem, Ann-Cathrin; [2]  Fridsten, Susanne; Blomqvist, Lennart [3] 
  1. Centre of Surgical Gastroenterology, Karolinska Univ. Hospital and Karolinska Inst., Stockholm (Sweden)
  2. Dept. of Gynecological Oncology, Radiumhemmet, Karolinska Univ. Hospital and Karolinska Inst., Stockholm (Sweden)
  3. Dept. of Diagnostic Radiology Karolinska Univ. Hospital and Karolinska Inst., Stockholm (Sweden)
Publication Date:
Apr 15, 2011
Product Type:
Journal Article
Resource Relation:
Journal Name: Acta Oncologica (online); Journal Volume: 50; Journal Issue: 3; Other Information: 10.3109/0284186X.2010.541932
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; NMR IMAGING; CARCINOMAS; GYNECOLOGY; FERTILITY
OSTI ID:
1011599
Country of Origin:
Sweden
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 1651-226X; TRN: SE1108076
Availability:
Available from DOI: http://dx.doi.org/10.3109/0284186X.2010.541932
Submitting Site:
SWDN
Size:
page(s) 420-426
Announcement Date:
Apr 25, 2011

Citation Formats

Stenstedt, Kristina, Hellstroem, Ann-Cathrin, Fridsten, Susanne, and Blomqvist, Lennart. Impact of MRI in the management and staging of cancer of the uterine cervix. Sweden: N. p., 2011. Web. doi:10.3109/0284186X.2010.541932.
Stenstedt, Kristina, Hellstroem, Ann-Cathrin, Fridsten, Susanne, & Blomqvist, Lennart. Impact of MRI in the management and staging of cancer of the uterine cervix. Sweden. doi:10.3109/0284186X.2010.541932.
Stenstedt, Kristina, Hellstroem, Ann-Cathrin, Fridsten, Susanne, and Blomqvist, Lennart. 2011. "Impact of MRI in the management and staging of cancer of the uterine cervix." Sweden. doi:10.3109/0284186X.2010.541932. https://www.osti.gov/servlets/purl/10.3109/0284186X.2010.541932.
@misc{etde_1011599,
title = {Impact of MRI in the management and staging of cancer of the uterine cervix}
author = {Stenstedt, Kristina, Hellstroem, Ann-Cathrin, Fridsten, Susanne, and Blomqvist, Lennart}
abstractNote = {Background. Cervical carcinoma is the only gynecological tumor still being staged mainly by clinical examination and only a limited use of diagnostic radiology. Cross sectional imaging is increasingly used as an aid in the staging procedure. We wanted to assess the impact of magnetic resonance imaging (MRI) in addition to the clinical staging of patients with carcinoma of the uterine cervix. Material and methods. A retrospective single-centre analysis of 183 women referred to a tertiary referral centre for gynecological tumors (<= 65 years old) with cervical cancer diagnosed between January 1, 2003 and December 31, 2006 who have undergone an MRI investigation before start of treatment. Patient records were retrospectively reviewed and any change of the planned treatment after the MRI examination was noted. Results. In patients with cervical carcinoma FIGO stage Ia2-IIa treated surgically, the treatment plan was altered due to MRI results in 10/125 patients. In the smaller group of patients with clinically more advanced disease receiving radio-chemotherapy, the treatment plan was altered in 12/58 patients. Reasons for changing the treatment plan after MRI were findings indicating a higher (n = 8) or lower (n = 5) local tumor stage, findings of para aortic nodal disease (n = 4) or difficulty to clinically examine the patient due to obesity (n = 2). MRI was also an aid in deciding whether or not to offer fertility preserving treatment in three cases. Conclusion. The use of MRI affects treatment planning in patients with cancer of the uterine cervix. The impact is more obvious in more advanced stages of disease and in patients who are difficult to examine clinically due to, for example body constitution. The result of MRI is also an aid in deciding whether or not a fertility preserving operation is feasible}
doi = {10.3109/0284186X.2010.541932}
journal = {Acta Oncologica (online)}
issue = {3}
volume = {50}
place = {Sweden}
year = {2011}
month = {Apr}
}