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Magnetic resonance imaging of tumor necrosis

Abstract

Background. The prognostic and predictive value of magnetic resonance (MR) investigations in clinical oncology may be improved by implementing strategies for discriminating between viable and necrotic tissue in tumors. The purpose of this preclinical study was to investigate whether the extent of necrosis in tumors can be assessed by dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and/or T2-weighted MR imaging. Material and methods. Three amelanotic human melanoma xenograft lines differing substantially in tumor necrotic fraction, necrotic pattern, extracellular volume fraction, and blood perfusion were used as experimental models of human cancer. MRI was performed at 1.5 T and a spatial resolution of 0.23 x 0.47 x 2.0 mm3. Gadolinium diethylene-triamine penta-acetic acid (Gd-DTPA) was used as contrast agent. Plots of Gd-DTPA concentration versus time were generated for each voxel, and three parameters were calculated for each curve: the extracellular volume fraction (V{sub e}), the final slope (a), and the Gd-DTPA concentration at one minute after the contrast administration (C{sub 1min}). Parametric images of V{sub e}, a, C{sub 1min}, and the signal intensity in T2-weighted images (SI{sub T2W}) were compared with the histology of the imaged tissue. Results. The V{sub e}, a, and C{sub 1min} frequency distributions were significantly different for necrotic  More>>
Publication Date:
Apr 15, 2011
Product Type:
Journal Article
Resource Relation:
Journal Name: Acta Oncologica (online); Journal Volume: 50; Journal Issue: 3; Other Information: 10.3109/0284186X.2010.526633
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; NMR IMAGING; CONTRAST MEDIA; NEOPLASMS; NECROSIS; GADOLINIUM; DTPA
OSTI ID:
1011598
Country of Origin:
Sweden
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 1651-226X; TRN: SE1108075
Availability:
Available from DOI: http://dx.doi.org/10.3109/0284186X.2010.526633
Submitting Site:
SWDN
Size:
page(s) 427-434
Announcement Date:
Apr 25, 2011

Citation Formats

Egeland, Tormod A. M., Gaustad, Jon-Vidar, Galappathi, Kanthi, and Rofstad, Einar K. (Group of Radiation Biology and Tumor Physiology, Dept. of Radiation Biology, Inst. for Cancer Research, Oslo Univ. Hospital, Oslo (Norway)), e-mail: einar.k.rofstad@rr-research.no. Magnetic resonance imaging of tumor necrosis. Sweden: N. p., 2011. Web. doi:10.3109/0284186X.2010.526633.
Egeland, Tormod A. M., Gaustad, Jon-Vidar, Galappathi, Kanthi, & Rofstad, Einar K. (Group of Radiation Biology and Tumor Physiology, Dept. of Radiation Biology, Inst. for Cancer Research, Oslo Univ. Hospital, Oslo (Norway)), e-mail: einar.k.rofstad@rr-research.no. Magnetic resonance imaging of tumor necrosis. Sweden. doi:10.3109/0284186X.2010.526633.
Egeland, Tormod A. M., Gaustad, Jon-Vidar, Galappathi, Kanthi, and Rofstad, Einar K. (Group of Radiation Biology and Tumor Physiology, Dept. of Radiation Biology, Inst. for Cancer Research, Oslo Univ. Hospital, Oslo (Norway)), e-mail: einar.k.rofstad@rr-research.no. 2011. "Magnetic resonance imaging of tumor necrosis." Sweden. doi:10.3109/0284186X.2010.526633. https://www.osti.gov/servlets/purl/10.3109/0284186X.2010.526633.
@misc{etde_1011598,
title = {Magnetic resonance imaging of tumor necrosis}
author = {Egeland, Tormod A. M., Gaustad, Jon-Vidar, Galappathi, Kanthi, and Rofstad, Einar K. (Group of Radiation Biology and Tumor Physiology, Dept. of Radiation Biology, Inst. for Cancer Research, Oslo Univ. Hospital, Oslo (Norway)), e-mail: einar.k.rofstad@rr-research.no}
abstractNote = {Background. The prognostic and predictive value of magnetic resonance (MR) investigations in clinical oncology may be improved by implementing strategies for discriminating between viable and necrotic tissue in tumors. The purpose of this preclinical study was to investigate whether the extent of necrosis in tumors can be assessed by dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and/or T2-weighted MR imaging. Material and methods. Three amelanotic human melanoma xenograft lines differing substantially in tumor necrotic fraction, necrotic pattern, extracellular volume fraction, and blood perfusion were used as experimental models of human cancer. MRI was performed at 1.5 T and a spatial resolution of 0.23 x 0.47 x 2.0 mm3. Gadolinium diethylene-triamine penta-acetic acid (Gd-DTPA) was used as contrast agent. Plots of Gd-DTPA concentration versus time were generated for each voxel, and three parameters were calculated for each curve: the extracellular volume fraction (V{sub e}), the final slope (a), and the Gd-DTPA concentration at one minute after the contrast administration (C{sub 1min}). Parametric images of V{sub e}, a, C{sub 1min}, and the signal intensity in T2-weighted images (SI{sub T2W}) were compared with the histology of the imaged tissue. Results. The V{sub e}, a, and C{sub 1min} frequency distributions were significantly different for necrotic and viable tissue in all three tumor lines. By using adequate values of V{sub e}, a, and C{sub 1min} to discriminate between necrotic and viable tissue, significant correlations were found between the fraction of necrotic tissue assessed by MRI and the fraction of necrotic tissue assessed by image analysis of histological preparations. On the other hand, the SI{sub T2W} frequency distributions did not differ significantly between necrotic and viable tissue in two of the three tumor lines. Conclusion. Necrotic regions in tumor tissue can be identified in parametric images derived from DCE-MRI series, whereas T2-weighted images are unsuitable for detection of tumor necrosis}
doi = {10.3109/0284186X.2010.526633}
journal = {Acta Oncologica (online)}
issue = {3}
volume = {50}
place = {Sweden}
year = {2011}
month = {Apr}
}