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High b-value diffusion-weighted MRI in differentiation between benign and malignant polypoid gallbladder lesions

Abstract

Background: Several studies have reported the effectiveness of high b-value diffusion-weighted MR imaging (DWI) in the abdominal region, and have found that various malignant tumors may show high signal intensity on DWI, reflecting their high cellularity and/or their long relaxation time. The value of ADC measurement has also been documented for the diagnosis of several abdominal malignancies. Purpose: To retrospectively evaluate the usefulness of high b-value DWI in differentiating between benign and malignant polypoid gallbladder lesions. Material and Methods: The study population consisted of 10 benign (three hyperplastic polyps and seven adenomas) and 13 malignant (all adenocarcinomas) polypoid gallbladder lesions. DWI was evaluated by two observers. Qualitatively, the signal intensity of the lesions on DWI was visually evaluated and categorized as iso, high, or very high. Quantitatively, the ADC values of the lesions were measured from ADC maps. Statistical analysis was performed using a two-tailed Fisher's exact test and the Mann-Whitney test, respectively. Results: Qualitative analysis revealed a statistical difference (P = 0.0041). Six of 10 benign lesions were categorized as iso, and the remaining four were categorized as high. In the 13 malignant lesions, one was categorized as iso, five as high, and seven as very high. The ADC  More>>
Authors:
Irie, Hiroyuki; Kamochi, Noriyuki; Nojiri, Junichi; Egashira, Yoshiaki; Sasaguri, Kohei; Kudo, Sho [1] 
  1. Dept. of Radiology, Faculty of Medicine, Saga Univ., Saga (Japan)
Publication Date:
Apr 15, 2011
Product Type:
Journal Article
Resource Relation:
Journal Name: Acta Radiologica (online); Journal Volume: 52; Journal Issue: 3; Other Information: 15 refs., 3 figs.; 10.1258/AR.2010.100234
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; NMR IMAGING; BILIARY TRACT; NEOPLASMS; ABDOMEN
OSTI ID:
1011582
Country of Origin:
Sweden
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 1600-0455; TRN: SE1108070
Availability:
Available from DOI: http://dx.doi.org/10.1258/ar.2010.100234
Submitting Site:
SWDN
Size:
page(s) 236-240
Announcement Date:
Apr 25, 2011

Citation Formats

Irie, Hiroyuki, Kamochi, Noriyuki, Nojiri, Junichi, Egashira, Yoshiaki, Sasaguri, Kohei, and Kudo, Sho. High b-value diffusion-weighted MRI in differentiation between benign and malignant polypoid gallbladder lesions. Sweden: N. p., 2011. Web. doi:10.1258/AR.2010.100234.
Irie, Hiroyuki, Kamochi, Noriyuki, Nojiri, Junichi, Egashira, Yoshiaki, Sasaguri, Kohei, & Kudo, Sho. High b-value diffusion-weighted MRI in differentiation between benign and malignant polypoid gallbladder lesions. Sweden. doi:10.1258/AR.2010.100234.
Irie, Hiroyuki, Kamochi, Noriyuki, Nojiri, Junichi, Egashira, Yoshiaki, Sasaguri, Kohei, and Kudo, Sho. 2011. "High b-value diffusion-weighted MRI in differentiation between benign and malignant polypoid gallbladder lesions." Sweden. doi:10.1258/AR.2010.100234. https://www.osti.gov/servlets/purl/10.1258/AR.2010.100234.
@misc{etde_1011582,
title = {High b-value diffusion-weighted MRI in differentiation between benign and malignant polypoid gallbladder lesions}
author = {Irie, Hiroyuki, Kamochi, Noriyuki, Nojiri, Junichi, Egashira, Yoshiaki, Sasaguri, Kohei, and Kudo, Sho}
abstractNote = {Background: Several studies have reported the effectiveness of high b-value diffusion-weighted MR imaging (DWI) in the abdominal region, and have found that various malignant tumors may show high signal intensity on DWI, reflecting their high cellularity and/or their long relaxation time. The value of ADC measurement has also been documented for the diagnosis of several abdominal malignancies. Purpose: To retrospectively evaluate the usefulness of high b-value DWI in differentiating between benign and malignant polypoid gallbladder lesions. Material and Methods: The study population consisted of 10 benign (three hyperplastic polyps and seven adenomas) and 13 malignant (all adenocarcinomas) polypoid gallbladder lesions. DWI was evaluated by two observers. Qualitatively, the signal intensity of the lesions on DWI was visually evaluated and categorized as iso, high, or very high. Quantitatively, the ADC values of the lesions were measured from ADC maps. Statistical analysis was performed using a two-tailed Fisher's exact test and the Mann-Whitney test, respectively. Results: Qualitative analysis revealed a statistical difference (P = 0.0041). Six of 10 benign lesions were categorized as iso, and the remaining four were categorized as high. In the 13 malignant lesions, one was categorized as iso, five as high, and seven as very high. The ADC values of the malignant lesions (1.34+-0.50 x 10-3 mm2/sec) were significantly lower than those of the benign lesions (2.26+-0.44 x 10-3 mm2/sec) (P = 0.00016). Conclusion: High b-value DWI may be useful for differentiating between benign and malignant polypoid gallbladder lesions by the visual assessment of DWI and ADC measurement}
doi = {10.1258/AR.2010.100234}
journal = {Acta Radiologica (online)}
issue = {3}
volume = {52}
place = {Sweden}
year = {2011}
month = {Apr}
}