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Cortical restricted diffusion as the predominant MRI finding in sporadic Creutzfeldt-Jakob disease

Abstract

Creutzfeldt-Jakob disease is a rare and fatal neurodegenerative disorder with MR findings predominantly limited to the grey matter of the cortex and the basal ganglia. Sporadic Creutzfeldt-Jakob disease can produce a spectrum of MR imaging findings of the brain, most notably on DWI and FLAIR sequences. Involvement of the basal ganglia and neocortex is the most common finding, but isolated involvement of the cortex can also be seen. We describe the clinical history and MRI findings of three patients with sporadic Creutzfeldt-Jakob disease confirmed by brain biopsy or autopsy and review the literature of imaging manifestations of this disease
Authors:
Talbott, Sabrina D; Sattenberg, Ronald J; Heidenreich, Jens O. (Dept. of Radiology, Univ. of Louisville, Louisville (United States)), e-mail: sdtalb02@gwise.louisville.edu; Plato, Brian M; [1]  Parker, John [2] 
  1. Dept. of Neurology, Univ. of Louisville, Louisville (United States)
  2. Dept. of Pathology and Laboratory Medicine, Univ. of Louisville, Louisville (United States)
Publication Date:
Apr 15, 2011
Product Type:
Journal Article
Resource Relation:
Journal Name: Acta Radiologica (online); Journal Volume: 52; Journal Issue: 3; Other Information: refs., figs., tabs.; 10.1258/AR.2010.100355
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CENTRAL NERVOUS SYSTEM; NMR IMAGING; BRAIN; ADULTS
OSTI ID:
1011576
Country of Origin:
Sweden
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 1600-0455; TRN: SE1108064
Availability:
Available from DOI: http://dx.doi.org/10.1258/ar.2010.100355
Submitting Site:
SWDN
Size:
page(s) 336-339
Announcement Date:
Apr 25, 2011

Citation Formats

Talbott, Sabrina D, Sattenberg, Ronald J, Heidenreich, Jens O. (Dept. of Radiology, Univ. of Louisville, Louisville (United States)), e-mail: sdtalb02@gwise.louisville.edu, Plato, Brian M, and Parker, John. Cortical restricted diffusion as the predominant MRI finding in sporadic Creutzfeldt-Jakob disease. Sweden: N. p., 2011. Web. doi:10.1258/AR.2010.100355.
Talbott, Sabrina D, Sattenberg, Ronald J, Heidenreich, Jens O. (Dept. of Radiology, Univ. of Louisville, Louisville (United States)), e-mail: sdtalb02@gwise.louisville.edu, Plato, Brian M, & Parker, John. Cortical restricted diffusion as the predominant MRI finding in sporadic Creutzfeldt-Jakob disease. Sweden. doi:10.1258/AR.2010.100355.
Talbott, Sabrina D, Sattenberg, Ronald J, Heidenreich, Jens O. (Dept. of Radiology, Univ. of Louisville, Louisville (United States)), e-mail: sdtalb02@gwise.louisville.edu, Plato, Brian M, and Parker, John. 2011. "Cortical restricted diffusion as the predominant MRI finding in sporadic Creutzfeldt-Jakob disease." Sweden. doi:10.1258/AR.2010.100355. https://www.osti.gov/servlets/purl/10.1258/AR.2010.100355.
@misc{etde_1011576,
title = {Cortical restricted diffusion as the predominant MRI finding in sporadic Creutzfeldt-Jakob disease}
author = {Talbott, Sabrina D, Sattenberg, Ronald J, Heidenreich, Jens O. (Dept. of Radiology, Univ. of Louisville, Louisville (United States)), e-mail: sdtalb02@gwise.louisville.edu, Plato, Brian M, and Parker, John}
abstractNote = {Creutzfeldt-Jakob disease is a rare and fatal neurodegenerative disorder with MR findings predominantly limited to the grey matter of the cortex and the basal ganglia. Sporadic Creutzfeldt-Jakob disease can produce a spectrum of MR imaging findings of the brain, most notably on DWI and FLAIR sequences. Involvement of the basal ganglia and neocortex is the most common finding, but isolated involvement of the cortex can also be seen. We describe the clinical history and MRI findings of three patients with sporadic Creutzfeldt-Jakob disease confirmed by brain biopsy or autopsy and review the literature of imaging manifestations of this disease}
doi = {10.1258/AR.2010.100355}
journal = {Acta Radiologica (online)}
issue = {3}
volume = {52}
place = {Sweden}
year = {2011}
month = {Apr}
}