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A feasibility study of MR elastography in the diagnosis of prostate cancer at 3.0T

Abstract

Background: MR elastography is a new imaging tool capable of non-invasively assessing the viscoelastic properties of tissues. The clinical application of MR elastography in the diagnosis of prostate cancer remains to be elucidated. Purpose: To investigate the feasibility of MR elastography in the diagnosis of prostate cancer at 3.0T, and to assess the elasticity and viscosity of prostate cancer and benign prostatic disease. Material and Methods: Eight patients (63 +- 7.25 years old) with 12 foci of prostate cancer and 10 patients (59 +- 3.25 years old) with 14 foci of prostatitis in the peripheral zone were evaluated by MRE. Ten healthy volunteers (41 +- 4.32 years old) with 18 ROIs in the peripheral zone of the prostate were also assessed with MR elastography as a control group. The results were confirmed by histopathological findings. All examinations were performed on a 3.0T Philips Achieva scanner. MRE was implemented by transmitting low-frequency longitudinal mechanical waves of 100Hz into the prostate with a transducer placed above the pubic bones. The phase images were reconstructed to acquire viscoelastic mapping. T-test was used to compare the mean elasticity and viscosity of prostate cancer and prostatitis. A comparison of prostate cancer and healthy prostate tissue  More>>
Authors:
Li, Saying; Chen, Min; Wang, Wenchao; Zhao, Weifeng; Zhou, Cheng; [1]  Wang, Jianye; [2]  Zhao, Xuna [3] 
  1. Dept. of Radiology, Beijing Hospital, Beijing (China)
  2. Dept. of Urology, Beijing Hospital, Beijing (China)
  3. Philips Medical System (China)
Publication Date:
Apr 15, 2011
Product Type:
Journal Article
Resource Relation:
Journal Name: Acta Radiologica (online); Journal Volume: 52; Journal Issue: 3; Other Information: refs., figs., tabs.; 10.1258/AR.2010.100276
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; NMR IMAGING; PROSTATE; NEOPLASMS; ELASTICITY; VISCOSITY
OSTI ID:
1011574
Country of Origin:
Sweden
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 1600-0455; TRN: SE1108062
Availability:
Available from DOI: http://dx.doi.org/10.1258/ar.2010.100276
Submitting Site:
SWDN
Size:
page(s) 354-358
Announcement Date:
Apr 25, 2011

Citation Formats

Li, Saying, Chen, Min, Wang, Wenchao, Zhao, Weifeng, Zhou, Cheng, Wang, Jianye, and Zhao, Xuna. A feasibility study of MR elastography in the diagnosis of prostate cancer at 3.0T. Sweden: N. p., 2011. Web. doi:10.1258/AR.2010.100276.
Li, Saying, Chen, Min, Wang, Wenchao, Zhao, Weifeng, Zhou, Cheng, Wang, Jianye, & Zhao, Xuna. A feasibility study of MR elastography in the diagnosis of prostate cancer at 3.0T. Sweden. doi:10.1258/AR.2010.100276.
Li, Saying, Chen, Min, Wang, Wenchao, Zhao, Weifeng, Zhou, Cheng, Wang, Jianye, and Zhao, Xuna. 2011. "A feasibility study of MR elastography in the diagnosis of prostate cancer at 3.0T." Sweden. doi:10.1258/AR.2010.100276. https://www.osti.gov/servlets/purl/10.1258/AR.2010.100276.
@misc{etde_1011574,
title = {A feasibility study of MR elastography in the diagnosis of prostate cancer at 3.0T}
author = {Li, Saying, Chen, Min, Wang, Wenchao, Zhao, Weifeng, Zhou, Cheng, Wang, Jianye, and Zhao, Xuna}
abstractNote = {Background: MR elastography is a new imaging tool capable of non-invasively assessing the viscoelastic properties of tissues. The clinical application of MR elastography in the diagnosis of prostate cancer remains to be elucidated. Purpose: To investigate the feasibility of MR elastography in the diagnosis of prostate cancer at 3.0T, and to assess the elasticity and viscosity of prostate cancer and benign prostatic disease. Material and Methods: Eight patients (63 +- 7.25 years old) with 12 foci of prostate cancer and 10 patients (59 +- 3.25 years old) with 14 foci of prostatitis in the peripheral zone were evaluated by MRE. Ten healthy volunteers (41 +- 4.32 years old) with 18 ROIs in the peripheral zone of the prostate were also assessed with MR elastography as a control group. The results were confirmed by histopathological findings. All examinations were performed on a 3.0T Philips Achieva scanner. MRE was implemented by transmitting low-frequency longitudinal mechanical waves of 100Hz into the prostate with a transducer placed above the pubic bones. The phase images were reconstructed to acquire viscoelastic mapping. T-test was used to compare the mean elasticity and viscosity of prostate cancer and prostatitis. A comparison of prostate cancer and healthy prostate tissue in elasticity was also evaluated. The correlation of elasticity and Gleason scores between prostate cancer and prostatitis were retrospectively analyzed with Pearson Correlation. Results: The mean elasticity and viscosity were significantly higher in the lesions with prostate cancer (6.55 +- 0.47 kPa, 6.56 +- 0.99 Pa.s, respectively) than in regions with prostatitis (1.99 +- 0.66 kPa, 2.13 +- 0.21 Pa.s). The difference between prostate cancer and prostatitis was statistically significant (t = 19.392, p < 0.01; t = 16.372, p < 0.01). The elasticity and viscosity of the healthy peripheral zone of prostate were 2.26 +- 0.45 kPa, 2.38 +- 0.54 Pa.s, respectively. There also was significant difference in elasticity between prostate cancer and normal peripheral zone (t = 25.136, p < 0.01). In addition, we observed a positive correlation between Gleason scores and elasticity of the prostate cancer (r = 0.913, P < 0.01) in this study. Conclusion: MR elastography can be used to visualize the difference in stiffness between prostate cancer and benign prostatic disease. It is a new imaging method with potential in the diagnosis of prostate cancer}
doi = {10.1258/AR.2010.100276}
journal = {Acta Radiologica (online)}
issue = {3}
volume = {52}
place = {Sweden}
year = {2011}
month = {Apr}
}