Non invasive detection and localisation of thrombogenesis in various clinical disorders remains a challenge. Mr. C. Ruan and his co-workers from the Jiangsu Institute of Hematology, Thrombosis and Hemostasis Research Unit, Suzhon Medical College, Suzhon, China, had successfully developed the entire steps from the production, purification and radiolabelling of a monoclonal antibody to an alpha granule protein expressed on the surface of activated platelets, to the validation of its immunoreactivity with activated platelets in few clinical disorders characterised by injury to platelets. Further, they have labelled this monoclonal antibody with 99mTc and demonstrated in vivo localisation of thrombogenic foli by an experimental model in dogs using immunoscintigraphic techniques. Biodistribution studies had clearly shown significant labelled antibody accumulation in thrombogenic foli compared to the surrounding blood and soft tissue background. Radiolabelled monoclonal antibody scintigraphy is thus shown to have potential in achieving the hitherto elusive goal of non invasive localisation of thrombogenesis in clinical practice.