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Monoclonal antibody (SZ-51) specific for activated platelets is useful in the diagnosis of thrombosis. Final report for the period December 1990 - April 1994

Technical Report:

Abstract

Non invasive detection and localisation of thrombogenesis in various clinical disorders remains a challenge. Mr. C. Ruan and his co-workers from the Jiangsu Institute of Hematology, Thrombosis and Hemostasis Research Unit, Suzhon Medical College, Suzhon, China, had successfully developed the entire steps from the production, purification and radiolabelling of a monoclonal antibody to an alpha granule protein expressed on the surface of activated platelets, to the validation of its immunoreactivity with activated platelets in few clinical disorders characterised by injury to platelets. Further, they have labelled this monoclonal antibody with 99mTc and demonstrated in vivo localisation of thrombogenic foli by an experimental model in dogs using immunoscintigraphic techniques. Biodistribution studies had clearly shown significant labelled antibody accumulation in thrombogenic foli compared to the surrounding blood and soft tissue background. Radiolabelled monoclonal antibody scintigraphy is thus shown to have potential in achieving the hitherto elusive goal of non invasive localisation of thrombogenesis in clinical practice.
Authors:
Chenggeng, Ruan [1] 
  1. Suzhou Medical College, Suzhou (China). Jiangsu Inst. of Hematology
Publication Date:
Aug 01, 1994
Product Type:
Technical Report
Report Number:
IAEA-R-6328-F
Reference Number:
SCA: 550601; 560162; PA: AIX-26:015865; EDB-95:031470; SN: 95001329371
Resource Relation:
Other Information: PBD: Aug 1994
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; CARDIOVASCULAR SYSTEM; SCINTISCANNING; THROMBOSIS; DIAGNOSIS; ANTIGEN-ANTIBODY REACTIONS; BLOOD SERUM; DIAGNOSTIC TECHNIQUES; DOGS; LABELLED COMPOUNDS; TECHNETIUM; TRACER TECHNIQUES; 550601; 560162; UNSEALED RADIONUCLIDES IN DIAGNOSTICS; ANIMALS, PLANTS, MICROORGANISMS, AND CELLS
OSTI ID:
10113634
Research Organizations:
International Atomic Energy Agency, Vienna (Austria)
Country of Origin:
IAEA
Language:
English
Other Identifying Numbers:
Other: ON: DE95615746; TRN: XA9438440015865
Availability:
OSTI; NTIS (US Sales Only); INIS
Submitting Site:
INIS
Size:
3 p.
Announcement Date:
Jun 30, 2005

Technical Report:

Citation Formats

Chenggeng, Ruan. Monoclonal antibody (SZ-51) specific for activated platelets is useful in the diagnosis of thrombosis. Final report for the period December 1990 - April 1994. IAEA: N. p., 1994. Web.
Chenggeng, Ruan. Monoclonal antibody (SZ-51) specific for activated platelets is useful in the diagnosis of thrombosis. Final report for the period December 1990 - April 1994. IAEA.
Chenggeng, Ruan. 1994. "Monoclonal antibody (SZ-51) specific for activated platelets is useful in the diagnosis of thrombosis. Final report for the period December 1990 - April 1994." IAEA.
@misc{etde_10113634,
title = {Monoclonal antibody (SZ-51) specific for activated platelets is useful in the diagnosis of thrombosis. Final report for the period December 1990 - April 1994}
author = {Chenggeng, Ruan}
abstractNote = {Non invasive detection and localisation of thrombogenesis in various clinical disorders remains a challenge. Mr. C. Ruan and his co-workers from the Jiangsu Institute of Hematology, Thrombosis and Hemostasis Research Unit, Suzhon Medical College, Suzhon, China, had successfully developed the entire steps from the production, purification and radiolabelling of a monoclonal antibody to an alpha granule protein expressed on the surface of activated platelets, to the validation of its immunoreactivity with activated platelets in few clinical disorders characterised by injury to platelets. Further, they have labelled this monoclonal antibody with 99mTc and demonstrated in vivo localisation of thrombogenic foli by an experimental model in dogs using immunoscintigraphic techniques. Biodistribution studies had clearly shown significant labelled antibody accumulation in thrombogenic foli compared to the surrounding blood and soft tissue background. Radiolabelled monoclonal antibody scintigraphy is thus shown to have potential in achieving the hitherto elusive goal of non invasive localisation of thrombogenesis in clinical practice.}
place = {IAEA}
year = {1994}
month = {Aug}
}