Abstract
This thesis concerns itself with the development of Nuclear Reaction Analysis (NRA). A technique to reject pile-up pulses and defective tail pulses from surface barrier detectors by the use of pulse shape discrimination (PSD) is demonstrated. The characteristic tau value for pile-up rejection is shown to be less than 56 ns. Its effects on detection limits from tail reduction in Particle Elastic Scattering Analysis (PESA) and pile-up peak suppression is discussed. The impact of the PSD technique on various NRA methods is discussed. Boron Neutron Capture Therapy (BNCT) is a cancer therapy whose efficiency depends on the location on a subcellular level of boron. In the work presented in this thesis an attempt is made to develop a method to analyze boron in biological tissue with a detection limit at the ng/cm2 level and a lateral resolution of about 1 micrometer. Various nuclear reactions have been investigated in order to find one that can be used with a Nuclear Microprobe (NMP). 10B has been studied with the photon-tagged Nuclear Reaction Analysis (pNRA) in the backward and forward directions. 11B has been studied at the broad low energy resonance (Ep=0.66 MeV) that emits alpha particles. It is shown that it is
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Citation Formats
Sjoeland, K A.
Nuclear reaction analysis - Development and application.
Sweden: N. p.,
1994.
Web.
Sjoeland, K A.
Nuclear reaction analysis - Development and application.
Sweden.
Sjoeland, K A.
1994.
"Nuclear reaction analysis - Development and application."
Sweden.
@misc{etde_10112197,
title = {Nuclear reaction analysis - Development and application}
author = {Sjoeland, K A}
abstractNote = {This thesis concerns itself with the development of Nuclear Reaction Analysis (NRA). A technique to reject pile-up pulses and defective tail pulses from surface barrier detectors by the use of pulse shape discrimination (PSD) is demonstrated. The characteristic tau value for pile-up rejection is shown to be less than 56 ns. Its effects on detection limits from tail reduction in Particle Elastic Scattering Analysis (PESA) and pile-up peak suppression is discussed. The impact of the PSD technique on various NRA methods is discussed. Boron Neutron Capture Therapy (BNCT) is a cancer therapy whose efficiency depends on the location on a subcellular level of boron. In the work presented in this thesis an attempt is made to develop a method to analyze boron in biological tissue with a detection limit at the ng/cm2 level and a lateral resolution of about 1 micrometer. Various nuclear reactions have been investigated in order to find one that can be used with a Nuclear Microprobe (NMP). 10B has been studied with the photon-tagged Nuclear Reaction Analysis (pNRA) in the backward and forward directions. 11B has been studied at the broad low energy resonance (Ep=0.66 MeV) that emits alpha particles. It is shown that it is possible to measure boron in biological tissue with the latter technique at the NMP. The problem to image the cell is also discussed. 3 refs.}
place = {Sweden}
year = {1994}
month = {Oct}
}
title = {Nuclear reaction analysis - Development and application}
author = {Sjoeland, K A}
abstractNote = {This thesis concerns itself with the development of Nuclear Reaction Analysis (NRA). A technique to reject pile-up pulses and defective tail pulses from surface barrier detectors by the use of pulse shape discrimination (PSD) is demonstrated. The characteristic tau value for pile-up rejection is shown to be less than 56 ns. Its effects on detection limits from tail reduction in Particle Elastic Scattering Analysis (PESA) and pile-up peak suppression is discussed. The impact of the PSD technique on various NRA methods is discussed. Boron Neutron Capture Therapy (BNCT) is a cancer therapy whose efficiency depends on the location on a subcellular level of boron. In the work presented in this thesis an attempt is made to develop a method to analyze boron in biological tissue with a detection limit at the ng/cm2 level and a lateral resolution of about 1 micrometer. Various nuclear reactions have been investigated in order to find one that can be used with a Nuclear Microprobe (NMP). 10B has been studied with the photon-tagged Nuclear Reaction Analysis (pNRA) in the backward and forward directions. 11B has been studied at the broad low energy resonance (Ep=0.66 MeV) that emits alpha particles. It is shown that it is possible to measure boron in biological tissue with the latter technique at the NMP. The problem to image the cell is also discussed. 3 refs.}
place = {Sweden}
year = {1994}
month = {Oct}
}