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Nuclear reaction analysis - Development and application

Thesis/Dissertation:

Abstract

This thesis concerns itself with the development of Nuclear Reaction Analysis (NRA). A technique to reject pile-up pulses and defective tail pulses from surface barrier detectors by the use of pulse shape discrimination (PSD) is demonstrated. The characteristic tau value for pile-up rejection is shown to be less than 56 ns. Its effects on detection limits from tail reduction in Particle Elastic Scattering Analysis (PESA) and pile-up peak suppression is discussed. The impact of the PSD technique on various NRA methods is discussed. Boron Neutron Capture Therapy (BNCT) is a cancer therapy whose efficiency depends on the location on a subcellular level of boron. In the work presented in this thesis an attempt is made to develop a method to analyze boron in biological tissue with a detection limit at the ng/cm2 level and a lateral resolution of about 1 micrometer. Various nuclear reactions have been investigated in order to find one that can be used with a Nuclear Microprobe (NMP). 10B has been studied with the photon-tagged Nuclear Reaction Analysis (pNRA) in the backward and forward directions. 11B has been studied at the broad low energy resonance (Ep=0.66 MeV) that emits alpha particles. It is shown that it is  More>>
Authors:
Publication Date:
Oct 06, 1994
Product Type:
Thesis/Dissertation
Report Number:
LUNFD6-NFFR-3064
Reference Number:
SCA: 440101; 440103; 550604; PA: AIX-26:011784; EDB-95:030933; SN: 95001324410
Resource Relation:
Other Information: TH: Thesis (FL).; PBD: 6 Oct 1994
Subject:
46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND TECHNOLOGY; 62 RADIOLOGY AND NUCLEAR MEDICINE; PULSE DISCRIMINATORS; NUCLEAR REACTION ANALYZERS; USES; SURFACE BARRIER DETECTORS; BIOLOGICAL MATERIALS; BORON; DESIGN; ION MICROSCOPY; NEUTRON CAPTURE THERAPY; NUCLEAR REACTION ANALYSIS; NUCLEAR REACTIONS; 440101; 440103; 550604; GENERAL DETECTORS OR MONITORS AND RADIOMETRIC INSTRUMENTS; NUCLEAR SPECTROSCOPIC INSTRUMENTATION; UNSEALED RADIONUCLIDES IN THERAPY
OSTI ID:
10112197
Research Organizations:
Lund Univ. (Sweden). Dept. of Nuclear Physics
Country of Origin:
Sweden
Language:
English
Other Identifying Numbers:
Other: ON: DE95613155; TRN: SE9400201011784
Availability:
OSTI; NTIS; INIS
Submitting Site:
SWDN
Size:
10 p.
Announcement Date:
Jun 30, 2005

Thesis/Dissertation:

Citation Formats

Sjoeland, K A. Nuclear reaction analysis - Development and application. Sweden: N. p., 1994. Web.
Sjoeland, K A. Nuclear reaction analysis - Development and application. Sweden.
Sjoeland, K A. 1994. "Nuclear reaction analysis - Development and application." Sweden.
@misc{etde_10112197,
title = {Nuclear reaction analysis - Development and application}
author = {Sjoeland, K A}
abstractNote = {This thesis concerns itself with the development of Nuclear Reaction Analysis (NRA). A technique to reject pile-up pulses and defective tail pulses from surface barrier detectors by the use of pulse shape discrimination (PSD) is demonstrated. The characteristic tau value for pile-up rejection is shown to be less than 56 ns. Its effects on detection limits from tail reduction in Particle Elastic Scattering Analysis (PESA) and pile-up peak suppression is discussed. The impact of the PSD technique on various NRA methods is discussed. Boron Neutron Capture Therapy (BNCT) is a cancer therapy whose efficiency depends on the location on a subcellular level of boron. In the work presented in this thesis an attempt is made to develop a method to analyze boron in biological tissue with a detection limit at the ng/cm2 level and a lateral resolution of about 1 micrometer. Various nuclear reactions have been investigated in order to find one that can be used with a Nuclear Microprobe (NMP). 10B has been studied with the photon-tagged Nuclear Reaction Analysis (pNRA) in the backward and forward directions. 11B has been studied at the broad low energy resonance (Ep=0.66 MeV) that emits alpha particles. It is shown that it is possible to measure boron in biological tissue with the latter technique at the NMP. The problem to image the cell is also discussed. 3 refs.}
place = {Sweden}
year = {1994}
month = {Oct}
}