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Studies on the production and application of radioisotopes -Studies on application of radiation and radioisotopes-

Technical Report:

Abstract

To increase the production of RI and labelled compounds utilizing the Korea Multipurpose Research Reactor (KMRR), development of P-32 production process, devices and tools of neutron irradiation use, GMP facilities of radiopharmaceuticals, Dy-165/Ho-166 macroaggregate of radiation synovectomy use for rheumatoid archritis have been carried out, respectively. To utilize NAA in analysis of environmental samples, experimental studies on air borne samples have also been carried out. An efficient P-32 production process obtaining high recovery of >98% with sufficiently high radionuclidic purity of >99% has been established through reaction {sup 32}S(n,p){sup 32}P and subsequent reduced pressure distillation purification. Various capsules, loading/unloading device for capsule/rigs, cole-welder for capsules, checking instrument for capsule sealing, working table/tools, transfer cask for the irradiated targets, etc. have been developed. To maintain cleanliness inside of hot cells, a modification has been proposed, and a two door type autoclave usable in GMP facility has been prepared. An efficient way of preparation of the Dy-165/Ho-166 macroaggregate of radiation synovectomy use as well as its clinical application scheme has been developed. A suitable process of environmental sample analyses has been established by carrying out NAA of standard/reference samples as well as airborne dust samples. (Author).
Publication Date:
Jul 01, 1994
Product Type:
Technical Report
Report Number:
KAERI/RR-1362/93
Reference Number:
SCA: 070100; PA: AIX-26:010769; EDB-95:027752; SN: 95001323895
Resource Relation:
Other Information: PBD: Jul 1994
Subject:
07 ISOTOPES AND RADIATION SOURCES; RADIOISOTOPES; ISOTOPE PRODUCTION; CHEMICAL REACTION YIELD; DISTILLATION; DYSPROSIUM 165; HOLMIUM 166; IMPURITIES; KMR REACTOR; NEUTRON ACTIVATION ANALYSIS; PHOSPHORUS 32; 070100; PHYSICAL ISOTOPE SEPARATION
OSTI ID:
10111405
Research Organizations:
Korea Cancer Center Hospital, Seoul (Korea, Republic of)
Country of Origin:
Korea, Republic of
Language:
Korean
Other Identifying Numbers:
Other: ON: DE95612655; TRN: KR9400193010769
Availability:
OSTI; NTIS; INIS
Submitting Site:
KRN
Size:
180 p.
Announcement Date:
Jun 30, 2005

Technical Report:

Citation Formats

Kim, Jae Rok, Park, Kyung Bae, Chung, Yong Sam, Chung, Young Ju, Bang, Hong Sik, Han, Hyun Soo, Shin, Byung Chul, Park, Choon Deuk, Han, Kwang Hee, Shin, Hun Young, Park, Woong Woo, Kim, Dong Soo, Kim, Jin Kyung, and Kim, Seung Jun. Studies on the production and application of radioisotopes -Studies on application of radiation and radioisotopes-. Korea, Republic of: N. p., 1994. Web.
Kim, Jae Rok, Park, Kyung Bae, Chung, Yong Sam, Chung, Young Ju, Bang, Hong Sik, Han, Hyun Soo, Shin, Byung Chul, Park, Choon Deuk, Han, Kwang Hee, Shin, Hun Young, Park, Woong Woo, Kim, Dong Soo, Kim, Jin Kyung, & Kim, Seung Jun. Studies on the production and application of radioisotopes -Studies on application of radiation and radioisotopes-. Korea, Republic of.
Kim, Jae Rok, Park, Kyung Bae, Chung, Yong Sam, Chung, Young Ju, Bang, Hong Sik, Han, Hyun Soo, Shin, Byung Chul, Park, Choon Deuk, Han, Kwang Hee, Shin, Hun Young, Park, Woong Woo, Kim, Dong Soo, Kim, Jin Kyung, and Kim, Seung Jun. 1994. "Studies on the production and application of radioisotopes -Studies on application of radiation and radioisotopes-." Korea, Republic of.
@misc{etde_10111405,
title = {Studies on the production and application of radioisotopes -Studies on application of radiation and radioisotopes-}
author = {Kim, Jae Rok, Park, Kyung Bae, Chung, Yong Sam, Chung, Young Ju, Bang, Hong Sik, Han, Hyun Soo, Shin, Byung Chul, Park, Choon Deuk, Han, Kwang Hee, Shin, Hun Young, Park, Woong Woo, Kim, Dong Soo, Kim, Jin Kyung, and Kim, Seung Jun}
abstractNote = {To increase the production of RI and labelled compounds utilizing the Korea Multipurpose Research Reactor (KMRR), development of P-32 production process, devices and tools of neutron irradiation use, GMP facilities of radiopharmaceuticals, Dy-165/Ho-166 macroaggregate of radiation synovectomy use for rheumatoid archritis have been carried out, respectively. To utilize NAA in analysis of environmental samples, experimental studies on air borne samples have also been carried out. An efficient P-32 production process obtaining high recovery of >98% with sufficiently high radionuclidic purity of >99% has been established through reaction {sup 32}S(n,p){sup 32}P and subsequent reduced pressure distillation purification. Various capsules, loading/unloading device for capsule/rigs, cole-welder for capsules, checking instrument for capsule sealing, working table/tools, transfer cask for the irradiated targets, etc. have been developed. To maintain cleanliness inside of hot cells, a modification has been proposed, and a two door type autoclave usable in GMP facility has been prepared. An efficient way of preparation of the Dy-165/Ho-166 macroaggregate of radiation synovectomy use as well as its clinical application scheme has been developed. A suitable process of environmental sample analyses has been established by carrying out NAA of standard/reference samples as well as airborne dust samples. (Author).}
place = {Korea, Republic of}
year = {1994}
month = {Jul}
}